Potassium Bis (trimethylsilyl) amide CAS 40949-94-8 (0.5M Xalka Toluene)
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Magaca Kiimikada | Potassium Bis (trimethylsilyl) amide |
La mid ah | Hexamethyldisilazane Potassium Salt;Potassium Hexamethyldisilazane;KHMDS |
Lambarka CAS | 40949-94-8 |
Lambarka CAT | RF-PI2227 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C6H18KNSi2 |
Miisaanka Molecular | 199.49 |
Barta Karsan | 111℃ |
Cufnaanta | 0.877 g/ml at 25 ℃ |
Heerka khatarta | 3 (8);Dareere guban kara, Daxaloobay |
Kooxda Baakadaha | II |
Solubility | Lasocon karo Terahydrofuran, Ether, Benzene iyo Toluene |
Biyuhu milmayn | La falgala Biyo |
Dareenka Hydrolytic | 8: Si degdeg ah uga falcelisa Qoyaanka, Biyaha, Xalka PProtic |
Xasilooni | Qoyaanka xasaasiga ah, Xasaasida Hawada, Xasaasida kulaylka.Ku kaydi Nitrojiinka hoostiisa.Waxa laga yaabaa inuu sameeyo Roob.Heerkulka deegaanka |
Badbaadada | Khatarta-Alaabaha Khatarta ah ee Dheeraadka ah ee Kharashka Xamuulka ah ayaa laga yaabaa in lagu dallaco |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Jaalle ilaa Brown Dareeraha |
Waxyaalaha kale ee wasakhda ah | ≤3.00% |
Nuxurka Saldhig Firfircoon | 0.45 ~ 0.55 M |
Heerka Imtixaanka | Heerka Ganacsiga |
Xidhmada:Dhalo, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Waxay u nugul tahay qoyaanka iyo hawada.Ku kaydi meel qabow.Weelka si adag u xidh meel engegan oo hawo fiican leh.Weelasha la furay waa in si taxadar leh dib loogu xiraa oo lagu hayaa toosan si looga hortago in ay daadsanto.Qabo oo ku kaydi gaaska aan shaqaynayn.Aan ku habboonayn walxaha oksaydhaynta ee xooggan.
Odhaahaha Khatarta:dareere aad u guban kara iyo uumiga.Waxay sababtaa gubasho daran oo maqaarka ah iyo dhaawaca isha.Waxay sababtaa dhaawac halis ah oo isha ah.Laga shakisan yahay inuu waxyeeleynayo taranka ama ilmaha aan dhalan.Waxa laga yaabaa inay waxyeelo u geysato xubnaha jirka oo muddo dheer ama soo noqnoqota soo gaadha.Waxay keeni kartaa lulmo ama dawakhaad.
Potassium Bis (trimethylsilyl) amide (0.5M Solution in Toluene) (sida caadiga ah loo soo gaabiyo KHMDS) (CAS: 40949-94-8) waa saldhig xooggan, aan ahayn nucleophilic oo leh qiyaasta pKa ee 26 (marka la barbardhigo lithium diisopropylamide, at 36). ).Waxaa ganacsi ahaan loo heli karaa sida adag iyo xal ahaan noocyo kala duwan oo dareere ah (tusaale THF, 2Me-THF, toluene, iyo MTBE).Reagen-yada la midka ah waxaa ka mid ah lithium bis (trimethylsilyl) amide (LiHMDS) iyo sodium bis (trimethylsilyl) amide (NaHMDS).Saldhig xooggan oo megasteric ah oo aan nucleophilic ahayn.Dhexdhexaadiyeyaasha dawooyinka, oo loo isticmaalo soo saarista cephalosporins synthetic.KHMDSwaa reagent kiimikaad loo isticmaalo diyaarinta chromatography dareeraha waxqabadka sare.Waxaa loo isticmaalaa in lagu sameeyo dhismo xasilan oo leh potassium, ka dibna waxaa kala sooca tiirka.KHMDS waxa kale oo loo isticmaalaa cilmi-baadhista kiimikaad iyo sidii kicinta isku-dhafka asymmetric.KHMDS waa saldhig xooggan oo loo isticmaalo isku-dhisyada carbonyl alkylation.KHMDS waxaa loo isticmaalaa diyaarinta 5-Azacytidine, daawada antineoplastic.Sidoo kale lagu dabaqay diyaarinta agonistayaasha β3-AR ee loo isticmaalo qaababka ka-hortagga walbahaarka.Waxa kale oo loo isticmaalaa sidii reagen ahaan diyaarinta dhismeyaasha lanthanide ee ka shaqeeya falcelinta baaskiilka ee xulashada ah.