Pregabalin CAS 148553-50-8 daahirnimo>99.0% (HPLC) API Antiepileptic
Soo-saare leh Nadiif Sarreysa iyo Wax soo saar Ganacsi
Magaca Kiimikada: PregabalinCAS: 148553-50-8
Pregabalin waa daawada suuxdinta jiilka labaad (AED)
Magaca Kiimikada | Pregabalin |
La mid ah | (S)-3-(Aminomethyl) -5-Methylhexanoic Acid;PD-144723;PD144723;CI 1008;CI-1008;Lyrica |
Lambarka CAS | 148553-50-8 |
Lambarka CAT | RF-API57 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C8H17NO2 |
Miisaanka Molecular | 159.23 |
Meesha dhalaalaysa | 194.0-196.0 ℃ |
Ku milmay biyaha | Dhaqan ahaan Aan Biyo Ku milmin |
Solubility | Wax yar oo ku milma Ethanol |
Xaalada Maraakiibta | Heerkulka deegaanka hoostiisa |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Aqoonsiga | IR: La mid ah Walxaha Tixraaca |
Wareeg gaar ah | +10.0°~+13.0° (C=1, Biyo) |
Khasaare xagga qalajinta | <0.50% |
Sulfated Ash | <0.10% |
Walxaha laxidhiidha | wasakh A <0.15% |
Wasakhda Aan La Sheegin Ka Hor Pregabalin (tijaabi A) <0.10% | |
Waxyaalaha wasakhda ah ee aan la cayimin ee ka baxaya Pregabalin ka dib (tijaabada B) <0.10% | |
Wadarta imtixaanka A iyo B <0.50% | |
Daahirnimada By HPLC R-Isomer | <0.15% |
Biraha culus (sida Pb) | <10pm |
Chlorides (Cl) | <0.05% |
Xalalka Haraaga ah | |
Khamriga isopropyl | <5000pm |
Ethyl acetate | <5000pm |
Tetrahydrofuran | <250ppm |
isopropyl Ether | <500pm |
Ethanol | <1000pm |
Daahirnimada / Habka Falanqaynta | > 99.0% (HPLC ku salaysan qallalan) |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Daawooyinka Antiepileptic API |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka & qoyaanka
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Pregabalin waa dawada ka hortagga suuxdinta ee jiilka labaad (AED) oo loo yaqaan magaca astaanta leh ee Lyrica (Pfizer, Tadworth) ee UK iyo USA, oo leh qaab dhismeedka γ-amino butyric acid ee qaab dhismeedka molecular, kaas oo leh saameyn liddi ku ah, waana si guul leh ay u soo saartay shirkadda Pfizer ee loogu talagalay daawaynta xanuunka neuropathic durugsan, ama daaweynta qalalka qayb ahaan.Pregabalin waa Anticonvulsant iyo daawada suuxdinta loo isticmaalo in lagu daweeyo suuxdin, xanuunka neuropathic, fibromyalgia, iyo khalkhalka guud ee walaaca.Isticmaalkeeda suuxdintu waa sida daawaynta dheeriga ah ee suuxdinta qayb ahaan leh ama aan lahayn guud ahaan guud ee dadka waaweyn.Bishii Disembar 2008, Maamulka Cunnada iyo Dawooyinka ee Mareykanka (FDA) ayaa ansixiyay pregabalin (magaca ganacsiga "Lyrica") ee loogu talagalay daawaynta xanuunka neerfaha ee sokorowga (DPN) iyo neuralgia postherpetic (PHN) kuwaas oo ah labadaba xanuunka neuropathic ee ugu caansan.Pregabalin waxay leedahay tilmaam la ansixiyay waxaana si weyn loogu isticmaalaa daawaynta xanuunka welwelka guud.Dhawr aan kala sooc lahayn, laba-indho la'aan, tijaabooyin la xakameeyey ayaa lagu ogaaday in pregabalin ay tahay daaweyn wax ku ool ah oo loogu talagalay bukaanada qaba xanuunka guud ee walwalka iyo xanuunka welwelka bulshada.Qiyaasta titration daawaynta suuxdinta-isku-dhafan: 25 mg bd muddo 7 maalmood ah, in lagu kordhiyo 50 mg 7dii maalmoodba;dayactirka caadiga ah 300 mg maalin kasta, loo qaybiyaa 2 ama 3 qiyaasood (ugu badnaan 600 mg maalintii, loo qaybiyey 2 ama 3 qiyaasood).Ciladda walwalka guud: 150 mg maalin kasta, oo loo qaybiyo 2 ama 3 qiyaasood, 7 maalmood, in lagu kordhiyo 150 mg 7dii maalmoodba mar (ugu badnaan 600 mg maalin kasta, oo loo qaybiyo 2 ama 3 qiyaasood).Haddii la joojiyo pregabalin, waxaa lagu talinayaa in la duubo ugu yaraan 1 toddobaad si looga fogaado ka-bax degdeg ah.Digniin Bukaanada qaba xaalado laga yaabo inay soo dajiyaan encephalopathy.Bukaanka qaba wadne xanuun daran.
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