Pyrazinamide CAS 98-96-4 daahirnimo>99.0% (HPLC)

Pyrazinamide (CAS: 98-96-4) waa dawada ka hortagga qaaxada ee safka labaad.Waxay leedahay saameyn liddi ku ah bakteeriyada nooca bini'aadamka ee Qaaxada Mycobacterium oo leh saameynta bakteeriyada ugu xoogga badan ee qiyaasta pH ee u dhaxaysa 5-5.5.Waxay si gaar ah u leedahay saamaynta bakteeriyada ugu fiican ee ka dhanka ah qaaxada Mycobacterium gudaha unugyada phagocytic ee qunyar u koraya ee deegaanka acidic.Ka dib markii pyrazinamide uu galo unugyada phagocytic oo uu galo jidhka qaaxada Mycobacterium, lactamase in vivo waxay ka dhigtaa mid aan la daboolin, oo loo beddelo pyrazine acid si uu u ciyaaro saameynta bakteeriyada.Pyrazinamide waxaa la sameeyay 1952, waana nitrogen-analog ee nicotinamide.Pyrazinamide waxa loo isticmaalaa daawayn ahaan sida wakiilka antitubercular.Pyrazinamide waxaa loo isticmaalaa in lagu sameeyo dhismooyin naxaas ah oo polymeric ah, abuurista pyrazine carboxamide scaffolds faa'iido leh sida FXs inhibitors, iyo sida qayb ka mid ah xirmooyinka aqoonsiga mycobacteria.Waxaa loo isticmaalaa in lagu barto ka hortagga sunta beerka iyo hababka iska caabinta.Pyrazinamide waa qayb muhiim ah oo ka mid ah daawaynta muddada-gaaban ee dawooyinka badan ee qaaxada.Marka lagu daro isoniazid iyo rifampin, waxay si firfircoon uga hortagtaa noolaha unugyada unugyada ee sababi kara soo noqoshada.