(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 daahirnimo ≥99.7% (GC) Chiral Purity
Qalabka wax-soo-saarka;Nadiif Sarreysa iyo Qiimaha Tartan
Shanghai Ruifu Chemical Co., Ltd. Qalabka Ganacsiga ee Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Dhexdhexaadiyaha Panipenem (CAS 87726-17-8) iyo Darifenacin hydrobromide (CAS 133099-07-7)
| Magaca Kiimikada | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| La mid ah | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Lambarka CAS | 104706-47-0 |
| Lambarka CAT | RF-CC102 |
| Daahirnimada / Habka Falanqaynta | ≥98.0% (GC) |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C4H10ClNO |
| Miisaanka Molecular | 123.58 |
| Meesha dhalaalaysa | 107.0 ~ 111.0 °C |
| Ku milmay biyaha | Ku dhawaad Hufnaan |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Off-White to Pale Brown Crystalline Powder |
| Daahirnimada / Habka Falanqaynta | ≥99.7% (GC) |
| Daahirnimada Chiral | ≥99.7% ee |
| Hadhaaga dabka | ≤0.50% |
| Wareeg gaar ah [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Xumaan Shaqsiyeed Kasta | ≤0.20% |
| Wadarta wasakhda | ≤0.30% |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyeyaasha Dawooyinka;Isku dhafka Chiral |
Habka Falanqaynta
Qalabka: Qalabka GC (Shimadzu GC-2010)
Tiirka: DB-17 Agilent 30mX0.53mmX1.0μm
Heerkulka foornada hore: 80 ℃
Waqtiga hore 2.0min
Qiyaasta 15 ℃/daq
Heerkulka foornada kama dambaysta ah: 250 ℃
Waqtiga ugu dambeeya 20min
Gaasta Nitrojiinka sidaha
Habka socodka joogtada ah
Socodka 5.0ml/min
Saamiga kala baxa 10:1
Heerkulka duritaanka: 250 ℃
Heerkulka qalabka: 300 ℃
Mugga cirbadeynta 1.0μL
Taxaddar in la sameeyo falanqaynta ka hor:
1. Tiirka xaalada 240 ℃ ugu yaraan 30 daqiiqo.
2. Ku dhaq saliingaha oo si fiican u nadiifi xuubka cirbadeynta si aad uga saarto wasakhda falanqaynta hore.
3. Ku dhaq, engeji oo ka buuxi milix weel lagu dhaqo saliingaha.
Diyaarinta qaska:
Ku diyaari 2% w/v xal sodium hydroxide biyaha.
Diyaarinta caadiga ah:
Ku miisaam qiyaastii 100mg of (R) -3-hydroxyprolidine hydrochloride heerka fijaan, ku dar 1mL oo qasin ah oo milmi.
Diyaarinta tijaabada:
Ku miisaam qiyaastii 100mg oo muunad tijaabo ah dhalo, ku dar 1mL oo dareere ah oo milmi.Ku diyaari nuqul
Habka:
Ku duri maran (diluent), diyaarinta caadiga ah iyo diyaarinta tijaabada adoo isticmaalaya xaaladaha ka sarreeya GC.Iska daa meelaha ugu sarreeya madhan awgeed.Waqtiga haynta ee ugu sarreysa sababtoo ah (R) -3-hydroxyprolidine waa qiyaastii 5.0min.
Fiiro gaar ah:
U soo sheeg natiijada celcelis ahaan
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya iyo alaab-qeybiyaha (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) oo leh tayo sare leh, oo si ballaaran loo isticmaalo isku-dhafka dabiiciga ah, isku-darka dhexdhexaadiyeyaasha dawooyinka iyo Waxyaalaha Farmashiyeedka Firfircoon (API)
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) waa dhexdhexaad caadi ahaan isku-dhafka Panipenem (CAS 87726-17-8) iyo Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) waa curiyaha hydroxy ee pyrrlodine ee loo isticmaalo diyaarinta xeryahooda niyooloji ahaan firfircoon sida muscarinic antagonists iyo wakiilada antimicrobial.
Jidka isku dhafka ah ee (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile waxaa lagu falceliyay trimethyl chlorosilane ee dareeraha dichloromethane si loo helo (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine ayaa markaa hydrogenateded on Pd / C kicinta.Ugu dambeyntii, badeecada (R) -3-hydroxypyrrolidine hydrochloride waxaa lagu helay daawaynta hydrochloric acid oo uruursan iyo kooxda ilaalinta trimethylsilyl waa laga saaray.
