(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6 Assay 98.0~102.0% (HPLC) Warshada
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(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6
Magaca Kiimikada | (R)-Lansoprazole |
La mid ah | R-(+)-Lansoprazole;Dexlansoprazole;2-[(R)-[3-Methyl-4- (2,2,2-trifluoroethoxy) -2-pyridinyl] methyl] sulfinyl] -1H-benzimidazole;T 168390;TAK 390;Lansoprazole nijaasta 14;Dexlansoprazole la xidhiidha wasakhda 2;(R) -2-[[3-Methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-Benzimidazole; |
Lambarka CAS | 138530-94-6 |
Lambarka CAT | RF-PI1916 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C16H14F3N3O2S |
Miisaanka Molecular | 369.36 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Solubility | Ku milmay Dimethylformamide, Ku dhawaad Biyo Aan Lagu milmi karin |
Cad & Midabka Xalka | Buuxiyay Shuruudaha |
Aqoonsiga IR | Muuqaalka nuugista infrared waa in uu ahaado mid waafaqsan walaxda tixraaca |
Aqoonsiga HPLC | Waqtiga haynta ee ugu sarreysa waa inuu ahaadaa mid waafaqsan tixraaca |
Wareeg gaar ah | +142.0°~+149.0° |
Meesha dhalaalaysa | ~ 140.0 ℃ |
Waxyaabaha Biyaha (KF) | <1.00% |
Hadhaaga dabka | <0.10% |
wasakhda la xidhiidha | (HPLC) |
Nitrogen Oxide | <0.10% |
Sulfone | <0.40% |
Sulfide | <0.20% |
Wax kasta oo kale oo aan nadiif ahayn | <0.10% |
Wadarta wasakhda | <0.60% |
Nadiifnimada indhaha (HPLC) | >99.5% |
Qiimayn | 98.0 ~ 102.0% (HPLC, % w/w, ku salaysan anhydrous, dareere-free) |
Biraha culus | <10pm |
Xalalka Haraaga ah | |
Toluene | <890ppm |
n-Heptane | <5000pm |
Bakteeriyada Endotoxin | <2.5EU/mg |
Heerka Imtixaanka | Heerka USP;Farmashiyaha Shiinaha |
Isticmaalka | API;Kahortagayaasha Pump Proton-ka Afka ee Firfircoon |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
(R)-Lansoprazole (CAS: 138530-94-6) waa R enantiomer ee Lansoprazole, Lansoprazole (AG 1749) waa ka hortag afka ah oo proton ah kaas oo ka ilaaliya caloosha inay soo saarto aashitada.Dexlansoprazole oo loogu talagalay Lansoprazole dextroisomer, waa nooc ka mid ah dawooyinka boogaha peptic-ka ee lagu beddelay derivatives benzimidazole, ee qaab-dhismeedka molecular galay element fluorine, labaad proton bamka inhibitors omeprazole ka dib.Dexlansoprazole waxay leedahay saameyn lagu xakameynayo dheecaanka acid gastric, saameyntu waxay ka fiican tahay daawooyinka kale (Omeprazole, Pantoprazole, Rebela, Tetrazolium) waxay si weyn u joojin kartaa dhacdooyinka boogaha.Way ka fiican tahay famotidine ama Omeprazole waxyeelada khamriga ay keentay xab-xabeedka gastric iyo boogaha duodenal ee inta badan ay keento dheecaanka aashitada.Intaa waxaa dheer, alaabtu waxay leedahay saameyn la mid ah ka hortagga Helicobacter pylori sida diyaarinta bismuth, waxaana loo isticmaalaa dib u soo noqoshada esophagitis iyo Zhuo AI syndrome.Takeda Pharmaceuticals waxay heshay oggolaansho dexlansoprazole, qaabaynta laba-sii daynta ah ee (R) -isomer ee lansoprazole proton pump inhibitor (PPI) oo horeba suuqa ugu jirtay, FDA bishii Janaayo 2009. Dexlansoprazole waa kaabsal sii deyn ah oo daahsan hal mar maalintii, daaweynta afka laab-jeexa oo la xidhiidha calaamadaha cudurka reflux gastroesophageal non-erosive (GERD), bogsashada erosive esophagitis (EE) iyo dayactirka EE bogsaday.