Ramelteon Intermediate 12 CAS 1053239-39-6 daahirnimo>98.0% (HPLC)
Soo saaraha iyo alaab-qeybiyaha hormuudka ah, Dhexdhexaadiyeyaasha Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-hal CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2- (2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
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| Magaca Kiimikada | 2- (2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride |
| La mid ah | Ramelteon Dhexdhexaadiyaha 12;Marxaladda Ramelteon-2 wasakh;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B] Furan-8-Ethanamine Hydrochloride |
| Lambarka CAS | 1053239-39-6 |
| Lambarka CAT | RF2887 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C13H18ClNO |
| Miisaanka Molecular | 239.74 |
| Meesha dhalaalaysa | 165.0 ~ 167.0 ℃ |
| Cufnaanta | 1.058± 0.06 g/cm3 |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Adag ee Cadaan ilaa Cadaan |
| Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) |
| Khasaare xagga qalajinta | <1.00% |
| Xumaanta Keliya | <1.00% |
| Wadarta wasakhda | <2.00% |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadka Ramelteon (CAS: 196597-26-9) |
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2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride (CAS: 1053239-39-6) waa dhexdhexaad ah Ramelteon (CAS: 196597- 26-9).Si ka duwan inta badan daawaynta hurdo la'aanta ee bartilmaameedka ah GABA (g-aminobutyric acid) receptor complex, Ramelteon waa agonist ee reseptor-ka melatonin.Gaar ahaan, waxay leedahay xulasho sare oo loogu talagalay noocyada MT1 iyo MT2, kuwaas oo lagu lug yeeshay dayactirka laxanka wareegga, oo ka sarreeya soo-dhoweeyaha MT3 ee mas'uul ka ah hawlaha kale ee melatonin.Xidhiidh la'aanta ma aha oo kaliya isku-xidhka soo-dhoweynta GABA, laakiin sidoo kale neurotransmitter, dopaminerigic, opiate, iyo reseptors benzodiazepine waxay soo jeedinaysaa astaan ammaaneed oo la wanaajiyey oo ka madhan kartida xadgudubka ee daawooyinka hypnotic ee bartilmaameedsada kuwan soo dhaweeyayaasha.Sidan oo kale, Ramelteon ma aha dawo la qorsheeyay.Dheef-shiid kiimikaad aasaasiga ah waxaa ka mid ah hydroxylation iyo oksaydheynta noocyada karbonyl ee leh dheef-shiid kiimikaad sare oo ka dhashay glucuronidation.Maadaama CYP1A2 ay tahay isozyme-ka ugu weyn ee ku lug leh dheef-shiid kiimikaad ee Ramelteon, waa inaan la qaadan iyadoo lagu darayo xakameynta CYP1A2 ee xooggan, sida fluvoxamine.Isku-darka ketoconazole (CYP3A4 inhibitor) ama fluconazole (xoogga CYP2C9 inhibitor) waxay keentay koror weyn oo AUC iyo Cmax ah, laakiin dheef-shiid kiimikaad ballaaran iyo uruurinta balaasmaha aadka u kala duwan ee Ramelteon ayaa diiday baahida loo qabo beddelka qiyaasta.Xirmada xirmada, si kastaba ha ahaatee, waxay uga digaysaa bukaanada ku saabsan wada-maamulka leh CYP3A4 iyo CYP2C9 horjoogayaasha awoodda leh.Iyada oo ku saleysan natiijada tijaabooyinka caafimaad, qiyaasta lagu taliyey ee Ramelteon waa 8mg oo la qaataa 30 daqiiqo gudahood markaad sariirta aadeyso.Marka lagu daro taxadarka wada-shaqeynta CYP-ka-hortaggayaasha, waa inaan loo isticmaalin bukaannada qaba naafanimada beerka ee daran.Dhacdooyinka xunxun, ee lagu arkay 5% bukaanada daraasadaha kiliinikada, waxay ahaayeen hurdo la'aan, dawakhaad, lallabbo, daal, madax xanuun, iyo hurdo la'aan.
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Ramelteon (TAK-375) CAS 196597-26-9 daahirnimo>99....
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2,3-Dihydrobenzofuran CAS 496-16-2 Ramelteon In...
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Despropionyl Ramelteon Hydrochloride CAS 196597...
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Ramelteon Acrylonitrile CAS 196597-79-2 Ramelte...
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Ramelteon Intermediate 12 CAS 1053239-39-6 Puri...
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Ramelteon Intermediate CAS 196597-78-1 daahirnimo >...