Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Sawirka Tayada Sare leh

Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Tayada Sare

Sharaxaad Gaaban:

Magaca Kiimikada: Remdesivir (GS-5734)

CAS: 1809249-37-3

Muuqashada: Budada Adag ee Cadaan ilaa Cadaan

Qiimaynta: 98.0% ~ 102.0%

Remdesivir oo loogu talagalay daawaynta COVID-19

API Tayada Sare, Wax soo saarka Ganacsiga

Inquiry: alvin@ruifuchem.com

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Sharaxaad:

Soo-saare Ganacsi Supply Remdesivir iyo Dhexdhexaadiyayaasha La Xiriira ee Tayada Sare leh
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy) phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosfinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Dhexdhexaadiyaha CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1

Guryaha Kiimikada:

Magaca Kiimikada	Remdesivir
La mid ah	GS-5734;2-ethylbutyl ((S)-((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl) methoxy) (phenoxy) fosfooryl -L-alaninate
Lambarka CAS	1809249-37-3
Lambarka CAT	RF-API96
Heerka Saamiyada	Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram
Qaanuunka molecular	C27H35N6O8P
Miisaanka Molecular	602.58
Cufnaanta	1.47±0.1 g/cm3
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada Adag ee Cadaan ilaa Cadaan
Aqoonsiga A	IR: Noocyada nuugista infrared-ka ee alaabtu waa inay la socotaa tan walaxda tixraaca
Aqoonsiga B	Waqtiga haynta HPLC oo la mid ah walaxda tixraaca
Wareeg gaar ah	-19.0° ~ -22.0°
Solubility	Sounle gudaha Methanol, Wax yar ku milmay Ethanol, Wax yar ku milmay Acetonitrile, Dhaqan ahaan aan Biyo ku milmin
Walxaha laxidhiidha
Xumaan Shaqsiyeed Kasta	≤0.10%
Wadarta wasakhda	≤1.0%
RD-3.1	≤0.10%
RD-C	≤0.10%
RD-D	≤0.10%
RD-E	≤0.10%
RP-Isomer	≤0.10%
Nitrophenol	≤0.10%
Xalalka Haraaga ah
Methanol Dichloride	≤6000ppm
Acetone	≤5000ppm
Khamriga isopropyl	≤5000ppm
Acetonitrile	≤410pm
Dichloromethane	≤600pm
Methyl tert Butyl Eter	≤5000ppm
Ethyl acetate	≤5000ppm
Tetrahydrofuran	≤720pm
n-Heptane	≤5000ppm
Qiimayn	98.0% ~ 102.0% (waxaa lagu xisaabiyaa habka qalalan)
Wadarta Tirooyinka Aerobic
Bakteeriyada hawada	≤100cfu/g
khamiirka iyo caaryada	≤10cfu/g
E. Gariiradda	xun
Bakteeriyada Endotoxin	≤1.0EU
Biraha culus	≤20pm
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	API, COVID-19

Xidhmada & Kaydinta:

Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.

Faa'iidooyinka:

FAQ:

Codsiga:

Remdesivir (CAS 1809249-37-3), oo lagu iibiyo magaca sumadda Veklury, waa daawo fayruska ka hortagga ah oo ballaaran oo ay soo saartay shirkadda biopharmaceutical ee Sayniska Gilecaad.Waxa lagu duraa irbad xididka.Intii lagu jiray masiibada COVID-19, remdesivir waa la oggolaaday ama loo oggolaaday isticmaalka degdegga ah si loogu daweeyo COVID-19 ilaa 50 waddan.Tilmaamaha la cusboonaysiiyay ee Ururka Caafimaadka Adduunka ee Noofambar 2020 waxa ka mid ah talobixin shuruudaysan oo ka dhan ah isticmaalka Remdesivir ee daawaynta COVID-19.Remdesivir waxaa markii hore loo sameeyay in lagu daweeyo cagaarshow C, ka dibna waxaa laga baaray cudurka fayraska Ebola iyo caabuqyada fayraska Marburg ka hor inta aan loo baran daawaynta caabuqa ka dib COVID-19.Saamaynta ugu badan ee tabaruceyaasha caafimaadka qaba ayaa ah kor u kaca heerarka dhiigga ee enzymes beerka (calaamad dhibaatooyinka beerka).Saamaynta ugu badan ee dadka qaba COVID-19 waa lalabo.Dhibaatooyinka soo raaca waxaa ka mid noqon kara bararka beerka iyo falcelinta faleebada la xiriirta lallabbo, cadaadis dhiig oo hooseeya, iyo dhidid.Remdesivir waa daawo loogu talagalay in lagu oggolaado gaarsiinta intracellular ee GS-441524 monophosphate iyo biotransformation ku xiga ee GS-441524 triphosphate, ribonucleotide analogue inhibitor ee fayraska RNA polymerase.