(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Nadiif Dhexdhexaad ah>99.0% (GC)

Sharaxaad Gaaban:

Magaca Kiimikada: (S)-1-Boc-3-Hydroxypiperidine

CAS: 143900-44-1

Nadiifnimada Chiral:>99.0% (GC)

Nadiifinta Kiimikada:>99.0% (GC)

Muuqashada: Budada cad ama kiristaalo

Dhexdhexaadka Ibrutinib (CAS: 936563-96-1)

Tayada Sare, Wax Soo Saarka Ganacsiga

E-Mail: alvin@ruifuchem.com

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Sharaxaad:

Dhexdhexaadiyeyaasha la xidhiidha Ibrutinib:
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxyphenylboronic Acid CAS 51067-38-0
Ibrutinib Dhexdhexaad N-2 CAS 330786-24-8
Ibrutinib Dhexdhexaad N-3 CAS 330792-70-6
Ibrutinib CAS 936563-96-1

Guryaha Kiimikada:

Magaca Kiimikada	(S)-1-Boc-3-Hydroxypiperidine
La mid ah	(S)-1-(tert-Butoxycarbonyl)-3-Hydroxypiperidine;(S)-1-Boc-3-Piperidinol
Lambarka CAS	143900-44-1
Lambarka CAT	RF-CC299
Heerka Saamiyada	Kaydka dhexdiisa, Awoodda Wax-soo-saarka 20 Tan/Bishii
Qaanuunka molecular	C10H19NO3
Miisaanka Molecular	201.27
Meesha dhalaalaysa	52.0 ~ 56.0 ℃
Solubility	Ku milma Methanol
Wareeg gaar ah [a]20/D	+9.0°~+11.0° (C=1 gudaha Chloroform)
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada cad ama kiristaalo
Daahirnimada Chiral	>99.5% (GC)
Nadiifnimada Kiimikada	>99.5% (GC)
Biyaha (KF)	≤0.50%
Methanol (GC)	≤50pm
Ethanol (GC)	≤50pm
DCM (GC)	≤500pm
3-Hydroxypiperidine	≤0.10%
3-Hydroxypyridine	≤0.20%
1-Boc-3-Piperidone	≤0.10%
1-Boc-4-Hydroxypiperidine	≤0.10%
1.96 RRT	≤0.20%
Najaasad kasta oo aan la cayimin	≤0.10%
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	Dhexdhexaadiyeyaasha Dawooyinka;Isku dhafka Chiral

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.

Faa'iidooyinka

FAQ:

Codsiga:

(S) -1-Boc-3-Hydroxypiperidine (CAS: 143900-44-1) waa dhexdhexaad muhiim ah oo chiral ah oo loogu talagalay isku dhafka Ibrutinib (CAS: 936563-96-1).Ibrutinib waa nooc ka mid ah Bruton tyrosine kinase (BTK) inhibitor, waxaa loo isticmaali karaa daaweynta lymphocytic leukemia raaga (CLL) iyo mantle cell lymphoma (MCL).MCL iyo CLL waxay ka tirsan yihiin B-cell non-Hodgkin's lymfoma, taas oo ay adag tahay in la daweeyo oo ay fududahay in ay soo noqnoqdaan.Dawaynta kiimikaad ee caadiga ah ma laha bartilmaameedka, badanaa waxay dhacdaa 3 ama 4 falcelin xun.Ibrutinib iyo B lymphocytes waxay bartilmaameedsan karaan BTK oo lagama maarmaan u ah samaynta, kala soocida, iyo gudbinta macluumaadka, waxay joojiyaan dhaqdhaqaaqa BTK si aan leexleexad lahayn, waxayna u diidaan faafinta unugyada burooyinka iyo badbaadada si wax ku ool ah.Ibrutinib si dhakhso ah ayaa loo nuugi karaa ka dib maamulka afka, inta lagu jiro 1 ~ 2h waxay gaaraan heerka ugu sarreeya ee dhiigga, falcelinta xun waxay ka tirsan tahay hal ama laba, sidaas darteed, Ibrutinib wuxuu noqon doonaa doorasho cusub oo lagu daweeyo CLL iyo MCL.