Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Nadiifinta>99.0% (HPLC) API Tayada Sare ee Warshada
Bixinta Sitagliptin Phosphate Monohydrate Dhexdhexaadiyaha La Xiriira:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Fosfate Monohydrate Dhexdhexaad CAS 486460-21-3
| Magaca Kiimikada | Sitagliptin Phosphate Monohydrate |
| La mid ah | (R) -3-amino-1- (3- (trifluoromethyl) -5,6-dihydro-[1,2,4]triazolo [4,3-a] pyrazin-7 (8H) -yl)-4- (2,4,5-trifluorophenyl) butan-1-hal phosphate monohydrate |
| Lambarka CAS | 654671-77-9 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C16H20F6N5O6P |
| Miisaanka Molecular | 523.3240802 |
| Meesha dhalaalaysa | 202.0 ~ 204.0 ℃ |
| Biyuhu milmayn | Ku milmay Biyaha |
| Wareeg gaar ah | -18.0°~-23.0° (C=1, Biyo) |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
| Aqoonsiga HPLC | Waqtiga haynta ee muunadku waa waafaqsan yahay heerka tixraaca |
| IR-Infrared Spectrum | Nuugista IR ee muunada waa in ay la jaanqaadaa heerka spectrum |
| Fosfate | U hogaansama |
| Daahirnimada / Habka Falanqaynta | > 99.0% (HPLC oo ku salaysan qalalan) |
| Waxyaabaha Biyaha (KF) | 3.3% ~ 4.4% |
| Hadhaaga dabka | ≤0.20% |
| Sulfate | ≤0.02% |
| Chloride | ≤0.05% |
| Xumaanta Chiral | <0.50% |
| Walxaha laxidhiidha | |
| Xumaanta Keliya | <0.50% |
| Wadarta wasakhda | <1.0% |
| Ethyl acetate | <0.50% |
| Biraha culus | <20ppm |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyeyaasha Daawooyinka |
Xidhmada: Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.
Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), daawo cusub oo loogu talagalay daawaynta nooca 2 ee sonkorowga.Bishii Agoosto 2009, dawada waxaa ansixiyay Midowga Yurub inay tahay dawada safka koowaad ee daaweynta nooca 2 ee sonkorowga.Sitagliptin Phosphate waa daawada ugu horreysa ee FDA-ansixisay dipeptidyl peptidase-IV inhibitor si loogu isticmaalo daawaynta nooca 2aad ee sonkorowga illaa iyo hadda, iyadoo hoos timaada magaca ganacsiga Januvia.Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) si degdeg ah oo wax ku ool ah waxay hoos u dhigtaa GLP-1, GLP-1, taas oo ah kicinta ugu waxtarka badan ee soo saarista insulin iyo dheecaanka Sidaa darteed, joojinta DPP-IV waxay kor u qaadi kartaa doorka GLP-1 endogenous, taas oo kordhinaysa dhiigga heerarka insuliinka, taas oo hoos u dhigaysa oo ilaalinaysa heerarka gulukooska dhiigga ee bukaanka macaanka.Waqtigan xaadirka ah, daawadu waxay xaqiijisay in DPP-IV inhibitor ay tahay nooc cusub oo ah dawada ka hortagga sonkorowga, iyo natiijooyinka caafimaadku waxay muujinayaan in dawooyinka ay leeyihiin saameyn wanaagsan oo hypoglycemic ah.Sababtoo ah GLP-1 waxay ka ciyaartaa kaalin gulukoos-ku-tiirsan kor u qaadida soosaarka insulinta iyo dheecaanka, falcelinta cakiran ee caadiga ah sida hypoglycemia iyo korodhka miisaanka oo ay keento isticmaalka dawooyinka ka hortagga sonkorowga ma dhacaan.
