Sitagliptin Triazole Hydrochloride CAS 762240-92-6 Nadiifinta>99.0% (HPLC) Warshada Tayada Sare
Bixinta Sitagliptin Phosphate Monohydrate Dhexdhexaadiyaha La Xiriira:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Fosfate Monohydrate Dhexdhexaad CAS 486460-21-3
Magaca Kiimikada | 3-(Trifluoromethyl) -5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a] pyrazine Hydrochloride |
La mid ah | Sitagliptin Triazole Hydrochloride;Dhexdhexaadiyaha Sitagliptin A |
Lambarka CAS | 762240-92-6 |
Lambarka CAT | RF-PI1193 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C6H7F3N4·HCl |
Miisaanka Molecular | 228.60 |
Meesha dhalaalaysa | 236.0 ~ 246.0 ℃ |
Solubility | Ku milma Methanol |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Cadaan iyo Off-White |
Aqoonsiga HPLC | Waqtiga haynta ee muunadku waa waafaqsan yahay heerka tixraaca |
Aqoonsiga IR | U hogaansama |
Khasaare xagga qalajinta | <0.50% |
Walxaha laxidhiidha | |
Xumaan Keli ah | <0.50% |
Wadarta wasakhda | <1.00% |
Biraha culus | <20ppm |
Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyaha Sitagliptin Fosfate Monohydrate (CAS: 654671-77-9) |
Xidhmada: Dhalo, bacda bireed ee aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.
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3- (Trifluoromethyl) -5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a] pyrazine Hydrochloride (CAS: 762240-92-6) waa dhexe ee Sitagliptin Phosphate Monohydrate ( CAS: 654671-77-9), kaas oo ah af-bioailable oo la xushay DPP4 inhibitor kaas oo lagu ogaaday iyada oo loo marayo hagaajinta fasalka β-aminoacid-derived DPP4 inhibitors.Waxay hoos u dhigtaa dhaqdhaqaaqa DPP4 si joogto ah ka dib hal mar maamulka maalinlaha ah, waxay ilaalisaa heerarka wareega ee GIP iyo GLP1 ka dib cuntooyinka labadaba daraasadaha degdega ah iyo kuwa dabadheerba waxayna yareeyaan heerarka gulukooska dhiigga iyada oo aan la kordhinin hypoglycaemia.Sitagliptin Phosphate (STG) waxaa loo isticmaalaa daawaynta DM nooca 2 sababtoo ah waxay wanaajisaa xakamaynta glycemic iyadoo kordhinaysa heerarka hormoonnada incretin ee firfircoon, GLP-1 (peptide-1) iyo GIP (glucose-based insulinotropic peptide).STG waxaa ansixiyay FDA 2006.