Sorafenib CAS 284461-73-0 Nadiifinta ≥99.0% (HPLC) API Tayada Sare
Qalabka Ganacsiga ee Sorafenib Tosylate iyo Dhexdhexaadiyeyaasha la xidhiidha:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Magaca | Sorafenib |
| La mid ah | Saldhigga Xorta ah ee Sorafenib |
| Lambarka CAS | 284461-73-0 |
| Lambarka CAT | RF-API04 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C21H16ClF3N4O3 |
| Miisaanka Molecular | 464.82 |
| Cufnaanta | 1.454± 0.06 g/cm3 |
| Solubility | Ku milmay DMSO |
| Shuruudaha Rarida | Heerkulka deegaanka |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ilaa budo cad-cad |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) |
| Aqoonsiga | H-NMR, MS |
| Khasaare xagga qalajinta | ≤1.0% |
| Hadhaaga dabka | ≤0.10% |
| Xumaanta Keliya | ≤0.20% (HPLC) |
| Wadarta wasakhda | ≤1.0% (HPLC) |
| Biraha culus | ≤20pm |
| Cadaynta Xalka | U hoggaansamo Heerka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | RCC & HCC |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Sorafenib Tosylate (CAS: 475207-59-1) waa nooc cusub oo ah dawada antitumor-ka ee bartilmaameedka badan leh, waxaa soo saaray German Bayer Pharmaceuticals, waxayna soo bandhigtay firfircoonida antitumor ballaaran ee tijaabooyinka xoolaha ee hore.Sorafenib waxaa lagu heli karaa 200-mg kiniin ah oo loogu talagalay maamulka afka waxaana loo isticmaalaa daaweynta RCC iyo HCC.Sorafenib Tosylate (CAS: 475207-59-1) waxay isku mar saameyn kartaa unugyada burooyinka iyo xididdada dhiigga ee burooyinka.Waxay leedahay saameyn labanlaab ah antitumor: waxay xannibi kartaa dariiqyada gudbinta calaamadaha unugga ee dhexdhexaadinaysa RAF/MEK/ERK si ay si toos ah u joojiso koritaanka unugyada burooyinka, iyadoo sidoo kale la xakameynayo VEGF iyo walxaha koritaanka unugyada platelet (PDGF) si looga hortago samaynta dhiigga cusub ee buro maraakiibta, sidaas darteed si aan toos ahayn u joojinaya koritaanka unugyada burooyinka.Sorafenib waa horjooge Raf-1 iyo B-RAF iyo sidoo kale dhowr kinases tyrosine ah.
