Sorafenib Tosylate CAS 475207-59-1 Nadiifinta ≥99.0% (HPLC) API Tayada Sare
Qalabka Ganacsiga ee Sorafenib Tosylate iyo Dhexdhexaadiyeyaasha la xidhiidha:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Magaca Kiimikada | Sorafenib Tosylate |
| La mid ah | Nexavar;4-[4-[3-[4-Chloro-3-(Trifluoromethyl) phenyl] ureido] phenoxy] -N-Methylpicolinamide 4-Methylbenzenesulfonate;4-[4-[4-Chloro-3-(Trifluoromethyl) phenyl] carbamamido] phenoxy] -N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Lambarka CAS | 475207-59-1 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C21H16ClF3N4O3.C7H8O3S |
| Miisaanka Molecular | 637.03 |
| Meesha dhalaalaysa | 225.0 ilaa 230.0 ℃ |
| Xasaasi ah | Xasaasiyadda hawada, Xasaasida kulaylka |
| Solubility | Ku milmay biyaha (<1 mg/ml) at 25℃, DMSO (127 mg/ml) at 25℃, iyo ethanol (<1 mg/ml) at 25℃ |
| Shuruudaha Rarida | Meel Qabow & Qallalan (2 ~ 8 ℃), Ka ilaali iftiinka |
| COA & MSDS | La heli karo |
| Nolosha shelf | 2 Sano Hadii Si Wanaagsan Loo Dhigo |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha | Natiijooyinka |
| Muuqashada | Jaale fudud ama budo cad | U hogaansama |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) | 99.8% |
| Meesha dhalaalaysa | 225.0 ~ 230.0 ℃ | U hogaansama |
| Biraha culus | ≤10pm | <10pm |
| Khasaare xagga qalajinta | ≤0.50% | 0.12% |
| Hadhaaga dabka | ≤0.20% | 0.10% |
| Xumaan Keli ah | ≤0.50% | U hogaansama |
| Wadarta wasakhda | ≤0.50% | U hogaansama |
| NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Heerka Imtixaanka | Heerka Ganacsiga | U hogaansama |
| Isticmaalka | Sorafenib Tosylate (CAS: 475207-59-1) ee daawaynta RCC & HCC | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weel si adag u xiran.Ku kaydi bakhaar qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Xeerarka halista 36/37/38 - Ka xanaajiya indhaha, habdhiska neefsiga iyo maqaarka.
Sharaxaada Badbaadada S28 - Kadib taabashada maqaarka, isla markiiba ku dhaq saabuun-suds badan.
S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad.
Sorafenib Tosylate (CAS: 475207-59-1) waa nooc cusub oo ah dawada antitumor-ka ee bartilmaameedka badan leh, waxaa soo saaray German Bayer Pharmaceuticals, waxayna soo bandhigtay firfircoonida antitumor ballaaran ee tijaabooyinka xoolaha ee hore.Sorafenib waxaa lagu heli karaa 200-mg kiniin ah oo loogu talagalay maamulka afka waxaana loo isticmaalaa daaweynta RCC iyo HCC.Sorafenib Tosylate waxay isku mar saameyn kartaa unugyada burooyinka iyo xididdada dhiigga ee burooyinka.Waxay leedahay saameyn labanlaab ah antitumor: waxay xannibi kartaa dariiqyada gudbinta calaamadaha unugga ee dhexdhexaadinaysa RAF/MEK/ERK si ay si toos ah u joojiso koritaanka unugyada burooyinka, iyadoo sidoo kale la xakameynayo VEGF iyo walxaha koritaanka unugyada platelet (PDGF) si looga hortago samaynta dhiigga cusub ee buro maraakiibta, sidaas darteed si aan toos ahayn u joojinaya koritaanka unugyada burooyinka.
Sorafenib Tosylate, magaca ganacsiga Nexavar, waxaa markii ugu horreysay soo saaray Bayer Pharmaceuticals ee Jarmalka.Sorafenib Tosylate waa ka hortag badan oo kinase ah oo loo isticmaali karo in lagu daaweeyo cudurrada sida kansarka.Bishii Disembar 2005, waxaa oggolaaday US FDA inay noqoto dawada safka koowaad ee daaweynta kansarka kelyaha ee sareeyo.Bishii Agoosto 2009, ayaa si rasmi ah loogu taxay Shiinaha iyada oo la oggolaaday Maamulka Cuntada iyo Dawooyinka ee Gobolka.
Sorafenib Tosylate waa tyrosine kinases (VEGFR iyo PDGFR) iyo RAF/MEK/ERK cascade inhibitors, oo isku mar ku shaqeeya Raf-1,wtBRAF iyo V599EBRAF, oo leh IC50 ee 6 nM, 22 nM iyo 38 nM, siday u kala horreeyaan.
Sorafenib Tosylate waxay si isku mid ah u joojin kartaa noocyo kala duwan oo kinases ah oo ka jira unugga iyo dusha sare ee unugyada, oo ay ku jiraan RAF kinase, vascular endothelial factor factor receptor-2 (VEGFR-2), vascular endothelial factor factor receptor-3 (VEGFR-3), platelet. -Qaybaha kobaca ee ka soo jeeda receptor-β (PDGFR-β), KIT iyo FLT-3.Waxaa la arki karaa in sorafenib toluenesulfonate uu leeyahay saameyn laba geesood ah oo ka hortagga burooyinka.Dhinaca kale, waxay si toos ah u joojin kartaa koritaanka burooyinka iyadoo la joojinayo dariiqa calaamadaynta RAF / MEK / ERK;Dhanka kale, waxay joojin kartaa VEGFR iyo PDGFR.Oo xannibi formation of neovascularization burada, si dadban u joojiyaan koritaanka unugyada burada.Sorafenib Tosylate ilaa hadda waa daawada ugu waxtarka badan ee daaweynta kansarka beerka ee horumarka leh ee maamulka nidaamka, waxayna u badan tahay inay noqoto daawada cusub ee caadiga ah ee daaweynta cudurkan.
Sorafenib Tosylate maalintiiba hal mar oo afka laga qaato qaababka taranka xoolaha ee bini'aadamka ayaa muujiyay waxqabadyo kala duwan oo ka hortagga burooyinka, oo ay ku jiraan kansarka mindhicirka, kansarka unugyada unugyada yaryar, kansarka naasaha, melanoma, kansarka ganaca, leukemia iyo kansarka ugxan-sidaha iyo mouse kansarka unugyada kelyaha model, model RENCA.
