Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Nadaafadda Sare ee Warshada
Soo-saare leh Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: Tacrolimus
La mid ah: FK-506;Fujimycin
CAS: 104987-11-3
API, Tayo Sare, Wax Soo Saarka Ganacsiga
Magaca Kiimikada | Tacrolimus |
La mid ah | FK-506;Fujimycin |
Lambarka CAS | 104987-11-3 |
Lambarka CAT | RF-API46 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C44H69NO12 |
Miisaanka Molecular | 804.02 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budo Fiican oo Jaalle ah oo Off-Cad ah, ur aan lahayn, Dhadhan Macaan oo Gaar ah |
Aqoonsiga | Waa inay noqotaa falcelin togan |
Caddayn | U hoggaansamo Heerka |
pH | 5.0 ~ 6.0 |
Chloride | ≤0.014% |
Sulfate | ≤0.029% |
Biraha culus (Pb) | ≤10pm |
Arsenic | ≤0.0002% |
Qoyaanka (KF) | ≤8.0% |
Hadhaaga dabka | 18.0% ~ 22.0% |
Qiimayn | ≥72.0% (HPLC, oo ku salaysan qalalan) |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | API |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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Tacrolimus (sidoo kale FK-506 ama Fujimycin) waa daawo difaac difaac ah oo isticmaalkeeda ugu weyn uu yahay ka dib beerista xubnaha jirka si loo yareeyo dhaqdhaqaaqa habka difaaca bukaanka iyo markaa khatarta diidmada xubnaha.Waxa kale oo loo isticmaalaa diyaarinta jirka la mariyo ee daawaynta dermatitis atopic daran, uveitis refractory daran ka dib beerista dhuuxa lafta, iyo xaaladda maqaarka vitiligo.Tacrolimus ayaa markii ugu horreysay laga soo saaray maraq-halsano ee Streptomyces tsukuba, oo ah microbe ciidda laga helay Tsukuba, Japan.Magaca tacrolimus waxaa laga soo qaatay qaadashada 't' ee Tsukuba, magaca buurta laga soo saaray muunada ciidda, 'acrol' oo loogu talagalay macrolide iyo 'imus' oo loogu talagalay difaaca jirka.Inkasta oo qaab-dhismeed ahaan aan xidhiidh la lahayn cyclosporin, tacrolimus waxay muujinaysaa saameyn isku mid ah oo saameynaha difaaca jirka ee wakiilkan heerka gacanta iyo molecular.Daraasadihii ugu horreeyay waxay muujiyeen in tacrolimus uu ahaa difaac awood leh oo awood leh, oo muujinaya qiyaastii 100-laab oo ka weyn awoodda vitro marka loo eego cyclosporin ee xakameynaya firfircoonida unugyada T.Daraasadaha ku xiga ee vivo waxay muujiyeen tacrolimus inay waxtar u leedahay labadaba xakamaynta cudurka iskiis u dhaca iyo tijaabinta, iyo ka hortagga allograft iyo xenograft diidmada noocyada xayawaanka ee xubinta taranka.Markii hore, tacrolimus waxaa loo isticmaalay is-difaacidda nidaamka difaaca ee bukaannada lagu sameeyay tallaalka allograft si looga joojiyo inay diidaan tallaalkooda cusub.Si kastaba ha ahaatee, si kastaba ha ahaatee, iyada oo loo marayo faa'iidada jilicsanaanta sayniska, waxaa la ogaaday in tacrolimus ay soo saari karto natiijooyin wanaagsan oo ku saabsan cudurrada maqaarka ee qaar ka mid ah bukaannada la tallaalay.Helitaanka tacrolimus ayaa markaa horseeday faham weyn oo ku saabsan cudurrada maqaarka, tusaale ahaan dermatitis-ka atopic.Ka dib, codsiyada kale ee la mariyo ee tacrolimus ayaa la soo sheegay iyo isticmaalka wakiilkan ee maqaarka ayaa si tartiib tartiib ah u sii kordhaya.
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