Temozolomide (TMZ) CAS 85622-93-1 Assay 99.0%~101.0% API Nadiifnimada Sare ee Warshada
Bixinta Temozolomide iyo Dhexdhexaadiyeyaasha la xidhiidha:
Temozolomide CAS: 85622-93-1
4(5)-Amino-5(4)-Imidazolecarboxamide CAS: 360-97-4
5(4)-Amino-4(5)-Imidazolecarboxamide Hydrochloride CAS: 72-40-2
| Magaca Kiimikada | Temozolomide |
| La mid ah | 3,4-Dihydro-3-Methyl-4-Oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-Carboxamide |
| Lambarka CAS | 85622-93-1 |
| Lambarka CAT | RF-API29 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C6H6N6O2 |
| Miisaanka Molecular | 194.15 |
| Meesha dhalaalaysa | 212 ℃ dec. |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ilaa qafiif ah budada casaanka ah |
| Aqoonsiga | By IR, HPLC |
| Xalalka Haraaga ah | Dimethyl Sulphoxide ≤0.50% |
| Walxaha laxidhiidha | |
| Xumaanta AIC | ≤0.10% |
| Xumaanta Keliya | ≤0.10% |
| Nasasho aan la garanayn wasakhda | ≤0.30% |
| Wadarta wasakhda | ≤0.30% |
| Biraha culus | ≤10pm |
| Khasaare xagga qalajinta | ≤0.50% |
| Hadhaaga dabka | ≤0.10% |
| Qiimayn | 99.0% ~ 101.0% (HPLC ku salaysan qalalan) |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Walaxda Farmashiyeedka Firfircoon (API) |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha iyo soo saaraha ugu horreeya ee Temozolomide (CAS: 85622-93-1) oo leh tayo sare.Temozolomide (TMZ) waa walax alkylating afka ah oo loo isticmaalo daawaynta Glioblastoma Multiforme (GBM) iyo Astrocytomas, Metastatic Melanoma.
Temozolomide waa daawada ugu horeysa ee waxtarka leh ee afka laga qaato imidazole iyo tetrazine-class anticancer taas oo ka tirsan jiilka labaad ee wakiilka alkylating ee leh firfircoonida antitumor iyada oo aan la kicin dheef-shiid kiimikaad beerka ka dib maamulka afka.Waxaa lagu gartaa in si fudud loo dhex galo xannibaadda maskaxda-maskaxda, dulqaad wanaagsan oo aan lagu dul-kordhin dawooyinka kale ee sunta ah, iyo saamaynta isku-dhafka ah ee daaweynta shucaaca taas oo ku habboon daawaynta soo noqoshada glioma malignant ka dib daaweynta caadiga ah sida burooyinka glioblastoma multiforme ama astrocytoma xumaaday.Waa daawada safka koowaad ee daaweynta melanoma metastatic.
Temozolomide waxaa markii hore soo saaray Cancer Research UK Group, ka dibna waxaa loo wareejiyay Shirkadda Schering-Plough (Mareykanka) si loo horumariyo.Waxay leedahay qaab-dhismeedka kiimikaad cusub waxayna iska leedahay afar-imidazole derivative.1999-kii, waxaa la ansixiyay in laga soo galo EU iyo US halkaas oo tilmaanta la oggol yahay ee Maraykanku ay inta badan tahay daawaynta safka labaad ee glioblastoma multiforme iyo gliomas star denerative iyo calaamadaha la ansixiyay ee EU ayaa loogu talagalay daaweynta soo koraya ama soo noqoshada glioblastoma multiforme. kaas oo mar hore lagu sameeyay daawaynta caadiga ah.Waxtarka temozolomide ee daaweynta glioblastoma multiforme ayaa aqoonsi dheeraad ah ka helay Yurub.
