Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Warshada Kahortagga HIV Sawirka Tayada Sare

Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Warshada Kahortagga HIV Tayada Sare

Sharaxaad Gaaban:

Magaca: Tenofovir Alafenamide Hemifumarate (TAF)

CAS: 1392275-56-7

Cadaan ilaa Ku dhawaad Caddaan Crystals ama budada Crystalline

Qiimaynta: 98.0% ~ 102.0%

Daawooyin loogu talagalay Tenofovir, oo loo isticmaalo daawaynta isku dhafan ee daaweynta HIV-1 Caabuqa

Tayada Sare, Wax Soo Saarka Ganacsiga

Inquiry: alvin@ruifuchem.com

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Sharaxaad:

Qaybinta Ganacsiga ee Tenofovir Dhexdhexaadiyeyaasha la xidhiidha:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl) fosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl) adenine CAS 14047-28-0
Diethyl (Hydroxymethyl) fosfonate CAS 3084-40-0
Adenine CAS 73-24-5

Guryaha Kiimikada:

Magaca Kiimikada	Tenofovir Alafenamide Hemifumarate
La mid ah	TAF;GS-7340 Hemifumarate
Lambarka CAS	1392275-56-7
Lambarka CAT	RF-API91
Heerka Saamiyada	Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram
Qaanuunka molecular	C25H33N6O9P
Miisaanka Molecular	592.55
Heerkulka Kaydinta	Lagu xidhay qalalan, heerkulka qolka
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Cadaan ilaa Ku dhawaad Caddaan Crystals ama budada Crystalline
Solubility	Ku milma Dimethylformamide, iyo Methanol;Ku milmay Biyaha iyo THF;In yar oo ku milma Acetonitrile iyo Aan ku milmi karin Dichloromethane iyo Toluene
Aqoonsiga A	Muuqaalka nuugista IR waa in uu ahaado mid waafaqsan tixraaca
Aqoonsiga B	Waqtiga haynta ee ugu sarreysa xalka muunada ee chromatogram go'aaminta nuxurku waa waafaqsan yahay xalka tixraaca
Aqoonsiga C	Waqtiga haynta Fumaric Acid ee ugu sarraysa ee go'aaminta chromatogramka waxa ku jira waxa uu waafaqayaa halka ugu sarreysa ee tixraaca
Waxyaalaha biyaha (waxaa qoray KF)	≤1.0%
Cadaynta Xalka	Asal ahaan ma jiraan qaybo muuqda oo ku jira 2% (w/v) ee caddaynta Xalka Methanol
Haraaga Solvent
Acetonitrile	≤410pm
Ethanol	≤5000ppm
Dichloromethane	≤600pm
Toluene	≤890pm
Hadhaaga dabka	≤0.10%
Biraha culus	≤20pm
Walxaha laxidhiidha
PMPA	≤1.0%
PMPA Anhydride	≤0.75%
Hal Phenyl PMPA	≤1.0%
Najaasad kasta oo aan la cayimin	≤0.15%
Wadarta wasakhda	≤2.0%
Isomer	≤1.0%
Waxa ku jira Fumaric Acid	9.0% ~ 13.0% (oo ku saleysan anhydrous)
Xadka Microbial
Wadarta tirada Microbial Aerobic	≤1000CFU/g
Wadarta khamiirka iyo caaryada	≤100CFU/g
Escherichia Coli	Maqan
Qiimayn	98.0% ~ 102.0% (oo ku salaysan anhydrous iyo dareere-free)
Heerka Imtixaanka	Heerka Ganacsiga

Xidhmada & Kaydinta:

Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.

Faa'iidooyinka:

FAQ:

Codsiga:

Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, waa nucleotide reverse transcriptase inhibitor (NRTIs) iyo soo saaraha cusub ee Tenofovir (TFV).Marka la xannibo transcriptase-ka dambe, TAF waxay ka hortagtaa HIV inuu tarmo waxayna yareyn kartaa tirada HIV ee jirka.Tenofovir alafenamide waa daroogo, taas oo macnaheedu yahay inay tahay daroogo aan firfircoonayn.Jidhka dhexdiisa, tenofovir alafenamide waxa loo beddelaa Tenofovir diphosphate (TFV-DP).Tenofovir Alafenamide Fumarate waxa la ansixiyay Noofambar 2015 si loogu daweeyo HIV-1.