Tranexamic Acid CAS 1197-18-8 Assay 99.0 ~ 101.0% (Titration)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee Tranexamic Acid (CAS: 1197-18-8) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Tranexamic Acid,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Tranexamic acid |
| La mid ah | trans-4-(Aminomethyl) cyclohexanecarboxylic Acid;trans-Tranexamic acid;TAMCHA;AMCHA;HAKU;AMCA;t-AMCHA;trans-Amcha |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 1197-18-8 |
| Qaanuunka molecular | C8H15NO2 |
| Miisaanka Molecular | 157.21 g/mol |
| Meesha dhalaalaysa | > 300 ℃ ( shid) |
| Xasilooni | Hygroscopic |
| Biyuhu milmayn | Ku milmay Biyaha, Ku dhawaad Hufnaan |
| COA & MSDS | La heli karo |
| Tusaalaha bilaashka ah | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Budada Crystalline White | U hogaansama |
| Solubility | Ku milmay Biyaha iyo Asiidhka Glacial, Ku dhawaad Aan ku milmin Ethanol iyo Acetone (96%) | U hogaansama |
| IR Spectrum | In Concordance oo leh Tranexamic Acid CRS | U hogaansama |
| pH | 7.0-8.0 | 7.32 |
| Khasaare xagga qalajinta | <0.50% | 0.06% |
| Sulfate Ash | <0.10% | 0.02% |
| Biraha culus (Pb) | ≤10pm | <10pm |
| Chloride (Cl) | ≤140pm | <140pm |
| Arsenic (As) | ≤2pm | <2pm |
| Qiimayn | 99.0 ~ 101.0% (waxaa qoray Titration) | 99.84% |
| Walxaha laxidhiidha | ||
| Xumaanta A | <0.10% | 0% |
| Xumaanta B | <0.20% | 0.0815% |
| Xumaanta C | <0.10% | 0.0089% |
| Xumaanta D | <0.10% | 0.0063% |
| Wadarta wasakhda | <0.20% (marka laga reebo A,B) | 0.015% |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
Xidhmada:Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Tranexamic acid
C8H15NO2 157.2
trans-4-(Aminomethyl) cyclohexanecarboxylic acid;
Cyclohexanecarboxylic acid, 4- (aminomethyl) -, trans [1197-18-8].
Qeexitaan
Tranexamic acid waxa uu ka kooban yahay NLT 99.0% iyo NMT 101.0% ee C8H15NO2, oo lagu xisaabiyey hab qalalan.
AQOONSIGA
• Nuugista Infrared <197K>
ASSAY
Habka
Xalka muunada: 140 mg oo Tranexamic acid ah 20 mL oo ah glacial acetic acid
Nidaamka Titrimetric
(Fiiri Titrimetry <541>.)
Habka: Titration toos ah
Titrant: 0.1 N perchloric acid VS
Ogaanshaha barta dhamaadka: Potentiometric
Falanqaynta
Tusaalaha: Tusaale xal
Titrate leh 0.1 N perchloric acid VS, go'aaminta barta dhamaadka si awood leh.Samee titration maran.
ML kasta oo ah 0.1 N perchloric acid waxay u dhigantaa 15.72 mg ee C8H15NO2.
Shuruudaha aqbalaadda: 99.0% -101.0% ee salka qallalan
XANUUNKA
wasakhda aan noolaha ahayn
• Hadhaaga dabka <281>: NMT 0.1%;1-g muunad ayaa loo isticmaalaa
• Biraha culus, Habka II <231>: NMT 10 ppm
• Chloride iyo Sulfate, Chloride <221>: Qayb 0.51-g ah ma muujinayso koloriin ka badan inta u dhiganta 0.1 mL ee 0.020 N hydrochloric acid (0.014%).
Waxyeellada dabiiciga ah
Habka
Marxaladda wareegta: Ku mil 11.0 g oo ah monobasic sodium phosphate anhydrous gudaha 500 ml oo biyo ah, kuna dar 5 ml oo triethylamine ah, oo ay ku xigto 1.4 g oo ah sodium lauryl sulfate.Ku hagaaji aashitada fosfooraska la badhxay (10% w/w) una beddel pH 2.5, oo ku qas biyo ilaa 600 mL.Isku qas xalkan 400 ml oo methanol ah.
Xalka ku habboonaanta nidaamka: 0.2 mg/mL ee USP Tranexamic Acid RS iyo 0.002 mg/mL ee USP Tranexamic Acid Compound C RS ee biyaha
Xalka caadiga ah: 50 µg/ml ee USP Tranexamic Acid RS oo biyo ah
Tusaalaha xalalka: 10 mg/mL oo ah Tranexamic Acid biyo ku jira
Nidaamka Chromatographic
(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 220 nm
Tiirka: 4.6-mm × 25-cm;5-µm xirmo L1
Heerka socodka: 1 ml/min
Cabbirka duritaanka: 20 µL
Waqtiga socodsiinta: 3 jeer wakhtiga haynta tranexamic acid
Ku habboonaanta nidaamka
Tusaalaha: Xalka ku habboonaanta nidaamka
Shuruudaha ku habboonaanta
Xallinta: NLT 2.0 inta u dhaxaysa Tranexamic Acid iyo 0.002 mg/mL oo ah xarun la xidhiidha tranexamic acid
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolkiiba nijaasta shakhsi kasta ee qaybta Tranexamic Acid ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × (0.1F)
rU = jawaabta ugu sarraysa ee wasakh kasta oo ka timid xalka Tusaalaha
rS = jawaabta ugu sarreysa ee tranexamic acid ee xalalka caadiga ah
CS = fiirsashada USP Tranexamic Acid RS ee xalka caadiga ah (µg/ml)
CU = fiirsashada Tranexamic Acid ee xalka muunada (mg/mL)
F = qodobka jawaab celinta qaraabo (eeg Jadwalka wasakhda 1)
Shuruudaha aqbalaadda
Wasakhda Shakhsiyeed: Eeg Shaxda 1aad ee wasakhda.
Wadarta wasakhda: NMT 0.2%
[Xusuusin- iska daa wax kasta oo ugu sarreeya ee ka yar 0.025%.]
Shaxda wasakhaysan 1
Magaca Wakhtiga Haynta Qaraabada Shuruudaha Ogolaanshaha Qodobbada Jawaabta Qaraabo, NMT (%)
Iskudhis Tranexamic acid Aa 2.1 1 0.1
Iskudhis Tranexamic acid Bb 1.5 1.2 0.2
Iskudhis Tranexamic acid CC 1.1 0.005 0.1
Tranexamic acid 1.0 1.0 —
Iskudhis la xidhiidha aashitada Tranexamic Dd 1.3 0.006 0.1
trans, trans-4,4 ¢-(Iminodimethylene) di(cyclohexanecarboxylic) acid.
b cis-4-(Aminomethyl) cyclohexanecarboxylic acid.
c (RS)-4-(Aminomethyl) cyclohex-1-enecarbocylic acid.
d 4-Aminomethyl benzoic acid.
IMTIXAANO GAAR AH
Khasaarada qallajinta <731>: Ku qallaji 1.00 g at 105 hoosta faakuumka 2 saacadood.Waxay luminaysaa NMT 0.5% miisaankeeda.
SHURUUD DHEERAAD AH
Baakadaha iyo Kaydinta: Ku kaydi weelal cidhiidhi ah, kuna kaydi heerkul aan ka badnayn 30.
• Heerarka Tixraaca USP <11>
USP Tranexamic Acid RS Guji si aad u aragto Qaabdhismeedka
USP Tranexamic Acid La Xiriira Isku-dhafka C RS
(RS)-4-(Aminomethyl) cyclohex-1-enecarbocylic acid.
C8H13NO2 155
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
Suuqyada Waaweyn?Iibiya suuqa gudaha, Waqooyiga Ameerika, Yurub, Hindiya, Kuuriya, Jabbaan, Australia, iwm.
Faa'iidooyinka?Tayada sare, qiimo jaban, adeegyo xirfadeed iyo taageero farsamo, gaarsiin degdeg ah.
TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.
Tusaalooyinka?Badeecadaha intooda badani waxay bixiyaan muunado bilaash ah oo loogu talagalay qiimeynta tayada, kharashka dhoofinta waa in ay bixiyaan macaamiisha.
Hantidhawrka Warshada?Hantidhawrka warshada soo dhawoow.Fadlan horay u sii ballan.
MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.
Gaadiidka?By Express (FedEx, DHL), hawada, badda.
Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
Isku-dhafka gaarka ah?Waxay ku siin kartaa adeegyada isku-dhafka gaarka ah si ay ugu habboonaato baahiyahaaga cilmi-baarista.
Shuruudaha Lacag-bixinta?Qaansheegga Proforma ayaa marka hore la soo diri doonaa ka dib marka la xaqiijiyo dalabka, oo lagu soo lifaaqay macluumaadka bangigayaga.Lacag bixinta T/T (Telex Transfer), PayPal, Western Union, iwm.
Calaamadaha halista Xi - xanaaq badan
Xeerarka halista 36/37/38 - Ka xanaajiya indhaha, habdhiska neefsiga iyo maqaarka.
Sharaxaada Badbaadada
S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad.
S36 - Xidho dhar ilaalin ku habboon.
S37/39 - Xidho galoofyada ku haboon iyo ilaalinta indhaha/wejiga
WGK Germany 2
RTECS GU8400000
HS code 2922491100
Heerka Khatarta IRRATANT
Sunta LD50 ee jiirarka, jiirka (mg/kg): 1500, 1200 iv (Melander)
Tranexamic Acid (CAS: 1197-18-8) waa soosaar ka samaysan amino acid lysine.Tranexamic acid Koonfurta Ameerika) waxaa badanaa loo qoraa dhiig-bax badan.Tranexamic acid waa antifibrinolytic kaas oo si tartan ah u hor istaaga firfircoonida plasminogen ilaa plasmin, molecule mas'uul ka ah hoos u dhaca fibrin.Fibrin waa qaabka aasaasiga ah ee samaynta xinjirowga dhiigga ee hemostasis. Tranexamic acid waxay leedahay qiyaastii 8 jeer waxqabadka antifibrinolytic ee analooga da'da weyn, ε-aminocaproic acid.Markii ugu horreysay waxaa la shatiyeeyay 1957 waxayna heshay oggolaanshaheedii ugu horreeyay ee Mareykanka 1986. Tranexamic Acid Appliciton Waxaa loo isticmaalaa sida qurxinta qurxinta Waxaa si weyn loogu isticmaalaa bukaan-socodyada qalliinka, daawaynta gudaha, kaadi mareenka, dhalmada iyo haweenka, iwm si loogu daweeyo cudurrada dhiigga ee kala duwan iyo Dhiigbaxa aan caadiga ahayn inta lagu jiro qaliinka, iwm. Waxaa loo arkaa dawo dhiigbax ah, oo inta badan loo isticmaalo dhiigbaxa qalliinka weyn iyo dhalmada kadib.Dabcan, hemostasis waxay u badan tahay inay tahay sababta ugu yar ee daawada cadayga badan loogu daro rajada inay saameyn ku yeelato.
Tranexamic acid (CAS: 1197-18-8)
Qalliinka wadnaha
Caadi ahaan loo isticmaalo qalliinka wadnaha, labadaba iyo iyada oo aan lahayn marinka wadnaha sambabada.Waxay beddeshaa aprotinin.
Dhiigbaxa caadada
Waxa loo adeegsaday daawaynta ugu horraysa ee aan hormoonnada ahayn ee dhiig-baxa uterineine-ka ee aan shaqaynayn, iyo dhiig-bax culus oo la xidhiidha fibroids-ka ilmo-galeenka.Daraasad dhowaan la sameeyay ayaa muujisay in bukaannada lagu daweeyay tranexamic acid ay aad ugu dhow yihiin inay yeeshaan xinjirowga dhiigga iyo necrosis ee fibroids-ka, waxayna keeni karaan xanuun iyo qandho.
Saamaynta caddaynta
Daraasadaha kiliinikada ee sannado badan ayaa caddeeyey in tranexamic acid ay si waxtar leh oo degdeg ah u milmi karto meesha, taas oo gacan ka geysanaysa muujinta maqaar cad oo dhalaalaya oo qumman.Saamaynta dhibcaha-saarida ee tranexamic acid waxay qiyaastii 50 jeer ka badan tahay Vitamin C, iyo 10 jeer ka badan AHA.Xadka fiirsashada isticmaalku waa 2% -3%, iyo waxyaalaha la isku qurxiyo cadadka waa ku dhawaad 0.5%
1. Deganaanshiyo wanaagsan
Marka la barbar dhigo maaddooyinka caddeynta dhaqameed, aashitada tranexamic waxay leedahay xasillooni sare, caabbinta aashitada iyo alkali, si fududna uma saamayso deegaanka heerkulka;Ma jiro ilaalin side, wax dhaawac ah nidaamka gudbinta ma jiro, ma laha kicin.
2. Nidaamka maqaarku waa sahlan tahay in la nuugo
Waxay si gaar ah ugu habboon tahay dhibcaha khafiifinta, caddeynta iyo isku dheelitirka guud ee midabka maqaarka.Marka lagu daro iftiiminta dhibcaha, aashitada tranexamic waxay sidoo kale wanaajin kartaa daahfurnaanta midabka guud ee maqaarka iyo caajisnimada maqaarka gudaha.
3. Waxa ay libdhi kartaa dhibco madow, xuub jaale ah, calaamado finan, iwm
Dhibcaha madow waxaa keena dhaawaca UV iyo gabowga maqaarka iyo arrimo kale.Acid xinjirtu waxay joojin kartaa dhaqdhaqaaqa tyrosinase iyo melanocytes, waxay yaraynaysaa soo saarista melanin ee lakabka hoose ee epidermis, waxayna sidoo kale leedahay saamaynta ay ka saarto dhibcaha cas.
4. Badbaadada sare
Xaddiga ugu sarreeya ee isqurxintu waa 2% ~ 3%.
5. Saamaynta caddaynta
Tranexamic acid waxay ku haboon tahay dhammaan noocyada maqaarka si ay uga saarto midabaynta, caddaynta maqaarka iyo yaraynta dhibcooyinka, sida: Midabka ka dib soo-gaadhista qorraxda;Dhibco madow;Maqaarka xasaasiga ah;finanka iyo bararka;Daryeelka qaliinka kadib laysarka, daawaynta iftiinka garaaca.
