trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 daahirnimo>98.0% (HPLC) Afatinib Dimaleate Dhexdhexaad Sawirka

trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 daahirnimo>98.0% (HPLC) Afatinib Dimaleate Intermediate

Sharaxaad Gaaban:

trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Daahirsanaanta:>98.0% (HPLC)

Muuqashada: Caddaan ilaa ku dhawaad cad budo

Dhexdhexaadiyaha Afatiib Dimaleate (CAS: 850140-73-7)

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Sharaxaad:

Dhexdhexaadiyaha Keenida Kiimikada Ruifu ee Afatinib
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Afatiib Dimaleate CAS 850140-73-7
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Guryaha Kiimikada:

Magaca Kiimikada	trans-4-Dimethylaminocrotonic Acid Hydrochloride
La mid ah	trans 4-Dimethylaminocrotonic Acid HCl;(E) -4- (Dimethylamino) -2-Butenoic Acid Hydrochloride;(E)-4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4- (Dimethylamino) laakiin-2-Enoic Acid Hydrochloride;Afatiib int-2
Lambarka CAS	848133-35-7
Heerka Saamiyada	Suuqa dhexdiisa, Miisaanka Ganacsiga
Qaanuunka molecular	C6H12ClNO2
Miisaanka Molecular	165.62
Dareenka	HygroscopicQoyaanka xasaasiga ah
Meesha dhalaalaysa	160.0 ilaa 164.0 ℃
Solubility	DMSO (wax yar), Methanol (wax yar), Biyo (wax yar)
COA & MSDS	La heli karo
Asal ahaan	Shanghai, Shiinaha
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Caddaan ilaa ku dhawaad cad budo
Daahirnimada / Habka Falanqaynta	>98.0% (HPLC)
Daahirnimada / Habka Falanqaynta	>98.0% (NMR)
Qoyaanka (KF)	<0.50%
Hadhaaga dabka	<0.20%
Xumaanta Keliya	<0.50%
Biraha culus (sida Pb)	<20ppm
Infrared Spectrum	Waafaqsan Qaab-dhismeedka
1 H NMR Spectrum	Proton NMR Spectrum
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	Dhexdhexaadka Afatiib, Afatiib Dimaleate

Xidhmada & Kaydinta:

Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.

Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.

Nadiifnimada Chromatographic:

Qalabka: Agilent 1200 HPLC chromatograph, DAD detector.
Tiirka: Agilent XDB-C18,250*4.6mm, 5μm
Marxaladda mobilada: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml biyo
C: acetonitrile
Diyaarinta wajiga mobaylka ee isku dhafan: qaado 400ml B xal iyo 100ml acetonitrile, si fiican u walaaq oo siman, oo ku shub dareeraha hal weji.
Heerka socodka: 0.5ml/min54bar
Heerkulka tiirka: 25 ℃
Dhererka hirarka: 210nm
Xalka Tusaalaha: Marxaladda mobilada ayaa loo adeegsaday sida dareere, muunad adag: 0.0040g/2ml, cabbir muunad 2.0μl.

Faa'iidooyinka

FAQ:

Codsiga:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) waa reagent loo isticmaalo diyaarinta tyrosine kinase joojinaya wakiilada antitumor.trans-4-Dimethylaminocrotonic Acid Hydrochloride waxaa loo isticmaali karaa dhexdhexaad ah Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib waa daawo loo oggolaaday daawaynta kansarka sanbabada unugyada aan-yaraha ahayn (NSCLC), oo uu sameeyay Boehringer Ingelheim.Waxay u shaqeysaa sidii xakameynta angiokinase.Sida Lapatinib iyo Neratinib, Afatinib waa tyrosine kinase inhibitor (TKI) kaas oo sidoo kale si aan kala sooc lahayn u xannibaya fayraska koritaanka epidermal ee bini'aadamka 2 (Her2) iyo soo-dhoweeyaha koritaanka epidermal (EGFR) kinases.Afatirib ma aha oo kaliya firfircoon ka dhanka ah EGFRisbeddellada lagu bartilmaameedsado jiilka kowaad TKIs likeerlotinib ama gefitinib, laakiin sidoo kale ka dhanka ah kuwa aan xasaasi u ahayn daaweyntan caadiga ah.Sababtoo ah waxqabadkeeda dheeraadka ah ee ka dhanka ah Her2, waxaa laga baarayaa kansarka naasaha iyo sidoo kale EGFR iyo kansarrada kale ee Her2.Neratinib oo ay soo saartay shirkadda US Wyeth waa soo-qaadaha korriinka korriinka ee epidermal-ka (EGFR) ee aan la beddeli karin.Waa bar bartilmaameed badan oo ah molecule tyrosine kinase inhibitors yar oo HER 2 iyo HER1 ka dib Lapatinib, waana ErbB reseptor tyrosine kinase inhibitor ah oo aan laga noqon karin.Neratinib waxay si xushmad leh u joojin kartaa HER-1 iyo HER-2 ee qoyska EGFR (IC50 waxay ahayd 92 nmol/L iyo 59 nmol/L, siday u kala horreeyaan).Cilmi-baaris caafimaad ayaa muujisay in Neratinib uu saameyn weyn ku yeeshay kansarka sanbabada unugyada aan yareyn, kansarka mindhicirka, iyo kansarka naasaha.Tijaabada caafimaad ee wajigaⅡ waxay muujisay in Neratinib ay muujisay waxtarka wanaagsan iyo dulqaadka HER-2 bukaanada togan ee qaba kansarka naasaha ee sareeya kuwaas oo la siiyay daaweynta Trastuzumab ama aan la helin.Marxaladda Ⅲ tijaabada caafimaad ee kansarka naasaha waxay dhammaatay Sebtembar 2014.