Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Faytamiin E Polyethylene Glycol Succinate |
| La mid ah | Vitamin E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;Alfa-Tocopherol Polyethylene Glycol Succinate |
| Heerka Saamiyada | Suuqa dhexdiisa, Miisaanka Ganacsiga |
| Lambarka CAS | 9002-96-4 |
| Qaanuunka molecular | C33H54O5.(C2H4O) n |
| Meesha dhalaalaysa | 34.0 ~ 38.0 ℃ |
| Cufnaanta | 1.01g/cm3 |
| Xasaasi ah | Xasaasiyadda Hawada, Dareen Fudud, Qoyaan xasaasi ah |
| WGK Germany | 2 |
| Heerkulka Kaydinta | Meel Qabow & Qallalan (2 ~ 8 ℃) |
| COA & MSDS | La heli karo |
| Tusaale | La heli karo |
| Qoyska Kiimikada | Faytamiin E laga soosaaray |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Cad-ka-baxsan ilaa Jaalle Waxy Adag | U hogaansama |
| Aqoonsiga (GC) | Wakhtiga haynta ee ugu sarraysa ee xal muunadku waxa ay u dhigantaa kan xalalka caadiga ah | U hogaansama |
| Meesha dhalaalaysa | 34.0 ~ 38.0 ℃ | 36.0 ~ 36.6 ℃ |
| D-alfa Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Tocopherol bilaash ah | ≤1.5% | U hogaansama |
| Wareeg gaar ah | ≥+24.0° | +24.5° |
| Ku milmay biyaha | Muunad 20g ah ayaa lagu milmi karaa 80ml oo biyo ah oo karkaraya | Ku nadiifi 3 saacadood gudahood |
| Qiimaha acid | ≤0.27ml (0.10 N Sodium Hydroxide) | 0.22ml |
| Biraha culus (Pb) | ≤10pm | <10pm |
| Arsenic (As) | ≤1ppm | <1pm |
| Hogaamin | ≤3pm | <3pm |
| Meerkuri (Hg) | ≤0.1pm | <0.010pm |
| Xalalka Haraaga ah | ||
| Ethyl acetate | ≤50pm | Lama ogaan |
| Ethanol | ≤50pm | 23pm |
| Wadarta tirada saxanada | ≤1000CFU/g | <10CFU/g |
| Khamiir iyo caaryaal | ≤100CFU/g | <10CFU/g |
| Salmonella | xun | xun |
| Escherichia Coli | xun | xun |
| Psendomonas Aeruginosa | xun | xun |
| Staphylococcus Aureus | xun | xun |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weel si adag u xiran.Ku kaydi bakhaar qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Qeexitaan
Faytamiin E Polyethylene Glycol Succinate waa isku dhaf ay sameeyeen esterification of d-alpha tocopheryl acid succinate iyo polyetylen glycol.Isku dhafka ester-ku wuxuu ka kooban yahay glycol mono-esterified polyetylen iyo qadar yar oo ah glycol polyetylen-esterified.Waxay ka kooban tahay NLT 25.0% d-alpha tocopherol (C29H50O2).
AQOONSIGA
A. Imtixaanka Aqoonsiga Chromatographic ee Gaaska
Falanqaynta: U wad sida lagu faray imtixaanka nuxurka Alpha Tocopherol.
Shuruudaha aqbalaadda: Wakhtiga haynta ee ugu sarraysa ee xalka Tusaalaha waxay u dhigantaa kan xalalka caadiga ah.
LAXANKA
• Waxa ku jira Alpha Tocopherol
Miraha: 0.25 ml oo phenolphthalein TS ah 1 L oo khamri ah
Xalka caadiga ah ee gudaha: 12 mg / mL ee ethyl arachidate ee isooctane
Xalka caadiga ah: Ku wareeji 32.5 mg USP Alpha Tocopherol RS weel falcelin ku habboon.Ku dar 2 mL oo pyridine ah iyo 0.5 mL oo ah N,O-bis(trimethylsilyl)trifluoroacetamide oo leh 1% trimethylchlorosilane, oo ku kululee weelka 100 ilaa 10 daqiiqo.Qabooji weelka, ku dar 5.0 mL oo ah xal gudaha ah oo ay ku xigto 20 ml oo isooctane ah, oo rux.
Xalka Tusaalaha: Ku wareeji tiro u dhiganta 0.100-0.160 g oo Vitamin E Polyethylene Glycol Succinate dhalaalaysa 60 ilaa tuubo dhaqameed (qiyaastii 20 cm dheer iyo 2.5 cm dhexroor ah) oo ku qalabaysan koofiyad fur.Ku dar 40-50 mg ascorbic acid iyo dhowr jajab oo karkaraya, oo ay ku xigto 20 ml oo ah Solvent.[Fiiro gaar ah — Si tartiib ah ugu soo celi xalka iyada oo aan la sii dayn waxa ku jira.] Ku rid tuubada meel kuleyl ah oo la dhigay 100-150.Marka shaybaarku si buuxda u milmo, ku dar 0.25 g oo ah potassium hydroxide, oo sii wad dib u soo noqoshada 30 daqiiqo.Tuubada ka saar kulaylka, iyo inta ku jira weli kulul yihiin, ku dar 1-2 mL oo ah hydrochloric acid hoos u dhaca ilaa midabka casuuska uu baaba'o.Digniin — falcelin ka baxsan.U ogolow aashitada in ay hoos ugu soo dhaadhacdo gudaha tuubada si aad uga hortagto soo daadinta.] Qabooji tuubada, ka dibna ku dhaq dhinacyada tuubada 20 ml oo biyo ah.Ku dar 5.0 mL oo ah xalka caadiga ah ee gudaha, dabool, oo rux si aad u hubiso isku darka dhamaystiran.U oggolow tuubbadu inay istaagto ilaa laba lakab oo kala duwan ay abuurmaan.Ku wareeji 2.5-3.5 mL ee lakabka sare kuna rid weel falcelin ku habboon, oo ku dar 2.0 mL oo pyridine ah oo ay ku xigto 2.5 mL ee N,O-bis(trimethylsilyl)trifluoroacetamide oo leh 1% trimethylchlorosilane.Kuleylka 100 ilaa 10 daqiiqo.Qabow, ka dibna ku dar 12 mL oo isooctane ah.
Nidaamka Chromatographic
(Fiiri Chromatography 621, Habboonaanta Nidaamka.)
Qaabka: GC
Baaraha: ionization ololka
Tiirka: 0.25-mm × 15-m daboolka-silica-dabiiciga ah;oo lagu dahaadhay filim 0.25-µm ah oo ah wajiga G27
Heerkulka
Durida: 280
Baadh: 345
Tiirka: Eeg Shaxda 1.
Shaxda 1
Heerkulka hore
260 20 340 1
Gaasta qaada: Helium
Heerka socodka: 1.5 ml/min
Cabbirka duritaanka: 1 µL
Nooca duritaanka: Saamiga kala qaybsan, 200:1
Ku habboonaanta nidaamka
Tusaale: Xalka caadiga ah
Shuruudaha ku habboonaanta
Qodobka dabada: NMT 2.0 ee alfa tocopherol ugu sarreeya
Isbeddelka heerka qaraabada ah: NMT 2.0% ee saamiga aagga ugu sarreeya alfa tocopherol iyo aagga ugu sarreeya heerka gudaha
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo Tusaalaha Xalka
Xisaabi boqolkiiba d-alpha tocopherol (C29H50O2) ee qaybta Vitamin E Polyethylene Glycol Succinate ee la qaatay:
Natiijadu = (RU/RS) × (WS/WU) × 100
RU= saamiga gudaha gudaha
RS= saamiga gudaha gudaha
WS = miisaanka USP Alpha Tocopherol RS loo isticmaalo diyaarinta xal Standard (mg)
WU= miisaanka Vitamin E Polyethylene Glycol Succinate oo la qaaday si loogu diyaariyo xal muunada (mg)
Shuruudaha aqbalaadda: NLT 25.0%
IMTIXAANO GAAR AH
• Wareegga indhaha, Wareegga Gaarka ah 781S
[Fiiro gaar ah-Tijaabadani waxay tilmaamaysaa d-alpha tocopherol ka dib saponification.]
Xalka Tusaalaha: Ku wareeji 0.9 g oo ah Vitamin E Polyethylene Glycol Succinate, dhalaalaysa 60, tuubo shaybaar ku habboon oo koofiyad leh ku milmi 10.0 ml oo aalkolo ah.Ku rid tuubada meel kuleylkeedu yahay 100-105.[Fiiro gaar ah u-soo celi xalka si tartiib ah iyada oo aan la sii dayn waxa ku jira.] Marka shaybaarku si buuxda u milmo, ku dar 2-3 pellets ee sodium hydroxide, oo sii wad dib u soo noqoshada 30 daqiiqo oo dheeraad ah.Tuubada ka saar kulaylka, iyo inta ku jira weli kulul yihiin, dhexdhexaad ka isticmaal phenolphthalein sida tilmaame adiga oo si tartiib ah ugu daraya 10 ml oo biyo ah iyo hydrochloric acid (1:1) ilaa midabka casuuska uu baaba'ayo.[Taxadir- falcelinta ka baxsan.U ogolow xalka aashitada inuu hoos ugu soo dhaadhaco gudaha tuubada si looga hortago in ay soo boodaan.Ku dar 25.0 mL oo heptane ah, dabool, oo rux 1 daqiiqo si aad u hubiso in si fiican la isku qaso.U oggolow tuubbadu inay istaagto ilaa laba lakab oo kala duwan ay abuurmaan.U wareeji lakabka sare tuubo dhaqan oo nadiif ah oo qalalan, ka dibna ku dar 10.0 ml oo biyo ah xalka la helay.Dabool, rux oo oggolow lakabyada inay kala tagaan.U wareeji lakabka sare tuubo nadiif ah oo qalalan.Ku dar 10.0 ml oo ah xalalka potassium ferricyanide, oo loo diyaariyey in lagu milmo 2 g oo potassium ferricyanide ah 10.0 ml oo ah 0.2 M sodium hydroxide, oo beddel furka.Si xoog leh u rux ilaa 45 s, oo u ogolow lakabyada inay kala baxaan 30 daqiiqo.Haddii lakabka sare ee heptane uu cad yahay, sii wad cabbirka wareegga gaarka ah;haddaysan caddayn, ku qallaji soodhiyam sulfate anhydrous ka hor intaadan sii wadin baaritaanka.[Xusuusin-Isticmaal natiijooyinka baaritaanka nuxurka Alpha Tocopherol si aad u xisaabiso wareegtada gaarka ah.]
Shuruudaha aqbalaadda: NLT +24.0
• Biyo ku milmay
Tusaalaha: 20 g oo ah Vitamin E Polyethylene Glycol Succinate oo dhalaalay
Falanqaynta: Ku rid muunada weel quraarad ah oo saaran kicinta birlabeedka.Isla markiiba ku dar 80 ml oo biyo karkaraya markaad kareyso.U oggolow inaad ku qaboojiso heerkulka qolka adigoo walaaqaya si joogto ah.
Shuruudaha aqbalaadda: Xalku wuxuu ku caddaaday 3 saacadood gudahood.
• Qiimaha aysiidhka
Tusaalaha: 1 g oo ah Vitamin E Polyethylene Glycol Succinate
Falanqaynta: Ku mil muunada 25 mL oo ah isku dhafka aalkolada iyo ether (1:1) kaas oo laga saaray phenolphthalein oo leh 0.1 N sodium hydroxide.Ku dar 0.5 mL oo ah phenolphthalein TS, oo titrate ku dar 0.10 N sodium hydroxide ilaa uu xalku sii ahaanayo mid casuus ah kadib gariir 30 sekan
Shuruudaha aqbalaadda: NMT 0.027 mEq/g, oo u dhiganta NMT 0.27 mL ee 0.10 N sodium hydroxide
SHURUUD DHEERAAD AH
Baakadaha iyo Kaydinta: Ku kaydi weelal cidhiidhi ah, oo ku kaydi iftiinka ka ilaalinta.
• Calaamadeynta: Calaamadeynta waxay muujineysaa nuxurka d-alpha tocopherol, oo lagu muujiyey mg/g.
• Heerarka Tixraaca USP 11
USP Alpha Tocopherol RS
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Faytamiin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) waa wax soo saarka synthetic.Waxa loo heli karaa sidii caddaan-ka-baxsan ilaa cirro huruud ah waxy adag oo dhab ahaantii aan dhadhamin.Kiimiko ahaan, waa isku dhafka ka kooban monoesterified polyethylene glycol 1000, polyetylen glycol disterified 1000, polyethylene glycol 1000 bilaash ah, iyo tocopherol bilaash ah.
Faytamiin E Polyethylene Glycol Succinate ayaa si weyn loogu isticmaalay cilmi-baarista dawooyinka, sida solubilizer, dhiirrigeliye nuugista, emulsifier, balaastiijiyaha iyo gudbiyaha nidaamka gudbinta daawada biyaha-aan-milmi karin ama baruurta, sida kala firdhisanaanta adag, sidaha gaarsiinta daawada indhaha, sidayaasha sanka gaarsiinta daroogada, iwm. Sida cuntada lagu daro.
Faytamiin E Polyethylene Glycol Succinate waa soosaar biyo-milmi leh oo fitamiin E ah, waxaa lagu sameeyay falcelinta kooxda karboksyl ee fitamiin E succinate oo leh kooxda hydroxyl ee polyetylen glycol.Sababtoo ah waxa ku jira labada vitamin E lipophilic group iyo polyetylen glycol hydrophilic silsilad dheer, waxa uu leeyahay guryaha surfactant wanaagsan iyo milanka biyaha, taas oo si weyn u kordhin kartaa nuugista daawooyinka aan milmi karin ee mareenka caloosha iyo mindhicirka, bioavailability kordhay.
Sanadihii la soo dhaafay, cilmi-baarisyo badan ayaa ogaaday in TPGS aan loo isticmaali karin oo kaliya daawooyinka dawooyinka, laakiin sidoo kale waxay leedahay sifooyin badan oo gaar ah, sida kobcinta nuugista iyo wakiilada iska caabbinta daawooyinka badan, TPGS ayaa sidoo kale lagu dabaqi karaa prodrugs, micelles, liposomes, TPGS-copolymer sidayaal si loo hagaajiyo milanka, permeability iyo xasiloonida diyaarinta, si loo gaaro gaabis, sii daayo la xakameeyey iyo saamaynta bartilmaameedka, kor u nuugista ee daroogada.
1. Daawooyinka - Vitamin E-TPGS wuxuu si weyn u wanaajiyaa nuugista, bioavailability iyo waxtarka maaddooyinka dawooyinka (APIs)
2. Kaabista cuntada - Vitamin E-TPGS waxa loo isticmaalaa in lagu sameeyo kaabayaasha, gaar ahaan kuwa loo abuuray si loo hagaajiyo shaybaarka fitamiin E iyo nafaqooyinka kale ee lipophilic iyo nafaqeynta.
3. Cunnada iyo Cabbitaannada - Vitamin E-TPGS waxaa lagu shaqaaleysiin karaa xoojinta cuntooyinka iyo cabitaannada, cabitaannada isboortiga, biyaha iyo casiirka.
4. Daryeelka Shakhsi ahaaneed - Vitamin E-TPGS wuxuu u adeegaa sida ethanol bilaash ah, hypoallergenic, emulsifier aan xanaaqin / qaacida daryeelka shakhsi ahaaneed iyo codsiyada qurxinta
5. Badeecooyinka Nafaqada Xoolaha - Vitamin E-TPGS waxa uu siiya fiitamiin E aad loo nuugi karo oo noolaha laga heli karo oo loogu talagalay xayawaanka kuwaas oo aan si hufan u nuugin qaababka dhaqameed ee fitamiin E.
Faytamiin E polyetylen glycol succinate waa fiitamiin E (tocopherol) laga soosaaray oo asal ahaan loo isticmaalo sidii solubilizer ama wakiil emulsifying sababtoo ah sifooyinkeeda korka ah.Qaab dhismeedka, waa amphipathic iyo hydrophilic, oo ka duwan tocopherols, sidaas darteed waa derivative biyo-milmi kara oo loo isticmaali karo qaababka dawooyinka sida kaabsoosha, kiniiniyada, extrusion kulul, microemulsions, alaabta la mariyo, iyo parenterals.Mid ka mid ah codsiyada ugu muhiimsan waa adeegsigeeda gaadiid ahaan hababka gaarsiinta daroogada ku salaysan dufanka.Waxa kale oo loo isticmaali karaa sida isha fitamiin E. Vitamin E polyetylen glycol succinate ayaa lagu gartaa marka la eego habka ay u dhaqmaan iyo bartay sida Pglycoprotein inhibitor ah.
Faytamiin E polyetylen glycol succinate kuma habboona asiidh adag iyo alkalis xooggan.
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