Zoledronic Acid CAS 118072-93-8 Nadiifinta ≥99.7% API Tayada Sare
U keeni Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: Zoledronic Acid
CAS: 118072-93-8
Awoodda Farnesyl Diphosphate (FPP) Inhibitor Synthase
API Tayada Sare, Wax soo saarka Ganacsiga
| Magaca Kiimikada | Zoledronic acid |
| La mid ah | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2- (1H-imidazol-1-yl)-etylidene] bisfosphonic acid. |
| Lambarka CAS | 118072-93-8 |
| Lambarka CAT | RF-API90 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C5H10N2O7P2 |
| Miisaanka Molecular | 272.09 |
| Meesha dhalaalaysa | 193.0 ~ 204.0 ℃ |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
| Aqoonsiga | IR Spectrum muunadu waxay u dhigantaa heerka tixraaca |
| pH | 2.0 ~ 4.0 |
| Solubility | Si Xoogan U Soluble 0.1N Sodium Hydroxide Solution, In Yar Biyo Iyo 0.1N Hydrochloric Acid. |
| Walxaha laxidhiidha | |
| Xumaan Shaqsiyeed Kasta | ≤0.10% |
| Wadarta wasakhda | ≤0.30% |
| Khasaare xagga qalajinta | 5.0% ~ 7.0% |
| Chloride | ≤0.02% |
| Fosfit | ≤0.50% |
| Fosfate | ≤0.50% |
| Biraha culus | ≤10pm |
| daahirnimo | ≥99.7% |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API, FPP Synthase Inhibitor, Hypercalcemia ee malignantiga (HCM) |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Zoledronic Acid (CAS 118072-93-8) waa bisphophonate farnesyl diphosphate (FPP) synthase inhibitor ah oo awood leh (IC50=20 nM).Waxay joojisaa dib-u-soo-celinta lafaha-dhexdhexaadinta osteoclast.Waxay kaloo joojisaa calaamadaha Ras iyo koritaanka burada, waxayna ku keentaa apoptosis unugyada kansarka ganaca.Waxay beddeshaa kala-guurka epithelial-mesenchymal waxayna joojisaa cusboonaysiinta unugyada kansarka naasaha iyada oo la hawlgelinayo NF-kB.Zoledronic acid waxaa ansixiyay US FDA 2001 si loogu daweeyo hypercalcemia ee malignancy, dhibaato dheef-shiid kiimikaad oo nolosha khatar gelin karta.Hypercalcemia ee malignantiga waxay ku dhici kartaa ilaa 50% bukaanada laga helay kansarka naasaha ee sareeya, myeloma badan, iyo kansarka sambabada unugyada aan yarayn.Xaaladdani waxay soo baxdaa marka unugyada kiimikaad ee ay soo saarto burodu ay keento kicinta osteoclasts-ka.Marka ay korodho nabaad-guurka lafaha, waxaa jira sii dayn isku-dar ah oo kalsiyum ah oo ku jirta balasmaha.Marka qiyaasta serum ee kaalshiyamku si degdeg ah u kordho, kelyuhu ma xamili karaan culayska xad dhaafka ah, iyo natiijooyinka hypercalcemia.Zoledronic acid waxay si wax ku ool ah u yareysaa uruurinta kalsiyumka balaasmaha iyadoo la xakameynayo dib u soo celinta lafaha (joojinta dhaqdhaqaaqa osteoclastic iyo kicinta apoptosis osteoclast).Intaa waxa dheer zoledronic acid waxa u ansixisay US FDA daawaynta myeloma badan iyo lafaha lafaha ee la xidhiidha kansarka adag ee burada ku salaysan (tusaale, sujuud iyo sambabada).
