Sodium Bis(trimethylsilyl)amide (NaHMDS) CAS 1070-89-9 (2M soln. in THF)

Short Description:

Sodium Bis(trimethylsilyl)amide (2M soln. in THF)

Synonyms: NaHMDS 

CAS: 1070-89-9

Content of Active Base: 38.0~45.0%

Appearance: Yellow to Brown Liquid 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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1070-89-9 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Sodium Bis(trimethylsilyl)amide (NaHMDS) (CAS: 1070-89-9) (2M soln. in THF) with high quality. Ruifu Chemical can supply a series of active bases and Grignard reagents. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Sodium Bis(trimethylsilyl)amide, Please contact: alvin@ruifuchem.com

Active Bases:

1070-89-9 - Chemical Properties:

Chemical Name Sodium Bis(trimethylsilyl)amide (2M soln. in THF)  
Synonyms NaHMDS; NaMDS; Sodium Hexamethyldisilazide; Hexamethyldisilazane Sodium Salt; N-Sodiohexamethyldisilazane; (2M soln. in THF)
Stock Status In Stock, Production Capacity 50 Metric Tons per Year
CAS Number 1070-89-9
Molecular Formula C6H18NNaSi2
Molecular Weight 183.38 g/mol
Melting Point 171.0~175.0℃(lit.) 
Boiling Point 67℃ 
Flash Point 43°F  
Density 0.904 g/mL at 25℃ 
Store Under Inert Gas Store Under Inert Gas (Nitrogen)
Sensitive Moisture Sensitivee. May Form a Precipitate. Ambient Temperatures.
Water Solubility  Reacts 
Solubility  Soluble in Toluene, Ether, Terahydrofuran, Benzene  
Hydrolytic Sensitivity 8: Reacts Rapidly with Moisture, Water, Protic Solvents
COA & MSDS Available
Origin of Product    Shanghai, China
Product Categories
Active Bases 
Brand Ruifu Chemical

1070-89-9 - Specifications:

Items Specifications  Results
Appearance Yellow to Brown Liquid  Yellow Liquid 
Other Impurities <4.00% <4.00%
Content of Active Base 38.0~45.0% 43.98%
Content of THF 55.0~57.0% 56.0%
Conclusion The product has been tested and complies with the given specifications

1070-89-9 - Other Specifications:

1.0M Solution in THF, 20%
2.0M Solution in THF, 40%
1~2M Solution in MTBE
0.6M Solution in Toluene
Ruifu Chemical can supply other content solution according to the customer request.

1070-89-9 - Package/Storage/Shipping:

Package: Bottle, Drum, or according to customer's requirement.
Storage Condition: Moisture sensitive. Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Incompatible with oxidizing agents, strong oxidizing agents and oxygen.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

1070-89-9 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

1070-89-9 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

1070-89-9 - Risk and Safety:

Risk Codes R14 - Reacts violently with water
R34 - Causes burns
R19 - May form explosive peroxides
R11 - Highly Flammable
R67 - Vapors may cause drowsiness and dizziness
R65 - Harmful: May cause lung damage if swallowed
R63 - Possible risk of harm to the unborn child
R48/20 -
R14/15 -
R40 - Limited evidence of a carcinogenic effect
R37 - Irritating to the respiratory system
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S33 - Take precautionary measures against static discharges.
S16 - Keep away from sources of ignition.
S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S8 - Keep container dry.
UN IDs UN 3263 8/PG 2
WGK Germany 3
FLUKA BRAND F CODES 10-21
TSCA Yes
HS Code 2931900090
Hazard Class 4.3
Packing Group III

1070-89-9 - Application:

Sodium Bis(trimethylsilyl)amide (NaHMDS) (CAS: 1070-89-9) (2M soln. in THF) is a strong base used in organic synthesis for deprotonation reactions and base catalyzed reaction.
NaHMDS was first prepared in 1958 by Wittig and Krebs through the reaction of sodium amide and trimethylsilyl chloride. Since then, NaHMDS has been widely used in organic synthesis reactions due to its strong basicity and ability to deprotonate weak acids.
NaHMDS is a strong base; deprotonates ketones and esters to generate enolate derivative. NaHMDS is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, NaHMDS has been used as a nitrogen source for the preparation of primary amines. NaHMDS is useful as a sterically hindered base and as a nucleophile.
NaHMDS is a highly reactive base with a pKa value of approximately 25. NaHMDS is soluble in several types of organic solvents, such as tetrahydrofuran, diethyl ether, and toluene, but is insoluble in water. Its reactivity is due to the presence of a bulky trimethylsilyl group attached to the amide nitrogen, which makes the negatively charged nitrogen ion more accessible for reactions.
NaHMDS can be used in the preparation of new pharmaceuticals, agrochemicals, and materials for various applications.  

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