Sodium Bis(trimethylsilyl)amide (NaHMDS) CAS 1070-89-9 (2M soln. in THF)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Sodium Bis(trimethylsilyl)amide (NaHMDS) (CAS: 1070-89-9) (2M soln. in THF) with high quality. Ruifu Chemical can supply a series of active bases and Grignard reagents. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Sodium Bis(trimethylsilyl)amide, Please contact: alvin@ruifuchem.com
Chemical Name | Sodium Bis(trimethylsilyl)amide (2M soln. in THF) |
Synonyms | NaHMDS; NaMDS; Sodium Hexamethyldisilazide; Hexamethyldisilazane Sodium Salt; N-Sodiohexamethyldisilazane; (2M soln. in THF) |
Stock Status | In Stock, Production Capacity 50 Metric Tons per Year |
CAS Number | 1070-89-9 |
Molecular Formula | C6H18NNaSi2 |
Molecular Weight | 183.38 g/mol |
Melting Point | 171.0~175.0℃(lit.) |
Boiling Point | 67℃ |
Flash Point | 43°F |
Density | 0.904 g/mL at 25℃ |
Store Under Inert Gas | Store Under Inert Gas (Nitrogen) |
Sensitive | Moisture Sensitivee. May Form a Precipitate. Ambient Temperatures. |
Water Solubility | Reacts |
Solubility | Soluble in Toluene, Ether, Terahydrofuran, Benzene |
Hydrolytic Sensitivity | 8: Reacts Rapidly with Moisture, Water, Protic Solvents |
COA & MSDS | Available |
Origin of Product | Shanghai, China |
Product Categories |
Active Bases |
Brand | Ruifu Chemical |
Items | Specifications | Results |
Appearance | Yellow to Brown Liquid | Yellow Liquid |
Other Impurities | <4.00% | <4.00% |
Content of Active Base | 38.0~45.0% | 43.98% |
Content of THF | 55.0~57.0% | 56.0% |
Conclusion | The product has been tested and complies with the given specifications |
1.0M Solution in THF, 20%
2.0M Solution in THF, 40%
1~2M Solution in MTBE
0.6M Solution in Toluene
Ruifu Chemical can supply other content solution according to the customer request.
Package: Bottle, Drum, or according to customer's requirement.
Storage Condition: Moisture sensitive. Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Incompatible with oxidizing agents, strong oxidizing agents and oxygen.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes R14 - Reacts violently with water
R34 - Causes burns
R19 - May form explosive peroxides
R11 - Highly Flammable
R67 - Vapors may cause drowsiness and dizziness
R65 - Harmful: May cause lung damage if swallowed
R63 - Possible risk of harm to the unborn child
R48/20 -
R14/15 -
R40 - Limited evidence of a carcinogenic effect
R37 - Irritating to the respiratory system
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S33 - Take precautionary measures against static discharges.
S16 - Keep away from sources of ignition.
S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S8 - Keep container dry.
UN IDs UN 3263 8/PG 2
WGK Germany 3
FLUKA BRAND F CODES 10-21
TSCA Yes
HS Code 2931900090
Hazard Class 4.3
Packing Group III
Sodium Bis(trimethylsilyl)amide (NaHMDS) (CAS: 1070-89-9) (2M soln. in THF) is a strong base used in organic synthesis for deprotonation reactions and base catalyzed reaction.
NaHMDS was first prepared in 1958 by Wittig and Krebs through the reaction of sodium amide and trimethylsilyl chloride. Since then, NaHMDS has been widely used in organic synthesis reactions due to its strong basicity and ability to deprotonate weak acids.
NaHMDS is a strong base; deprotonates ketones and esters to generate enolate derivative. NaHMDS is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, NaHMDS has been used as a nitrogen source for the preparation of primary amines. NaHMDS is useful as a sterically hindered base and as a nucleophile.
NaHMDS is a highly reactive base with a pKa value of approximately 25. NaHMDS is soluble in several types of organic solvents, such as tetrahydrofuran, diethyl ether, and toluene, but is insoluble in water. Its reactivity is due to the presence of a bulky trimethylsilyl group attached to the amide nitrogen, which makes the negatively charged nitrogen ion more accessible for reactions.
NaHMDS can be used in the preparation of new pharmaceuticals, agrochemicals, and materials for various applications.
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