Special Design for Camptothecin II - Irinotecan Hydrochloride CAS 100286-90-6 API USP Standard High Purity – Ruifu
Special Design for Camptothecin II - Irinotecan Hydrochloride CAS 100286-90-6 API USP Standard High Purity – Ruifu Detail:
Manufacturer with High Purity and Competitive Price
Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
Chemical Name | Irinotecan Hydrochloride |
Synonyms | Camptothecin II; CPT-II |
CAS Number | 100286-90-6 |
CAT Number | RF-API50 |
Stock Status | In Stock, Production Scale Up to Tons |
Molecular Formula | C33H39ClN4O6 |
Molecular Weight | 623.15 |
Melting Point | 250-256℃ (dec.) |
Storage Conditions | Under Ambient Temperature |
Brand | Ruifu Chemical |
Item | Specifications |
Appearance | White or Off-White Powder |
Solubility | Soluble in water and methanol, slightly soluble in chloroform, ethanol |
Identification IR | The infrared absorption spectrum of the test sample should consistent with that of the reference standard |
Identification HPLC | The retention time of major peak of the sample solution should correspond to that of the reference standard. |
Identification | Meets the requirements of the tests for Chloride Positive reaction |
Moisture (K.F) | 7.0%~9.0% w/w |
Residue on Ignition | ≤0.10% |
Heavy Metals | ≤20ppm |
Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
7-Desethyl Irinotecan | ≤0.15% |
Irinotecan Related Compound A | ≤0.15% |
11-Ethyl Irinotecan | ≤0.15% |
Camptothecin | ≤0.15% |
Irinotecan Related Compound B | ≤0.15% |
7-Ethylcanptothecin | ≤0.15% |
7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
Any Unspecified Impurity | ≤0.10% |
Total Impurities | ≤0.50% |
Residual Solvents (GC) | |
Methanol | ≤2000ppm |
Acetone | ≤2000ppm |
Dichloromethane | ≤500ppm |
Peteoleum Ether: | ≤100ppm |
Ethyl Acetate | ≤2000ppm |
Benzene | ≤2ppm |
Bacterial Endotoxins | ≤0.29 EU/mg Irinotecan |
Microbial Limits | Total Aerobic Microbial Count: <1000 cfu/g |
Molds and Yeasts | <100 cfu/g |
Purity / Analysis Method | ≥99.0% (HPLC, on the anhydrous basis) |
Test Standard | United States Pharmacopeia (USP) Standard |
Usage | Active Pharmaceutical Ingredient (API) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
lrinotecan hydrochloride (CAS 100286-90-6), a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Although being much less toxic than camptothecin, a significant number of patients in clinical trials exhibited side effects of leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin’s lymphoma.
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