2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 Bohloeki ≥98.0% Olaparib Intermediate Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: 2-Fluoro-5-Formylbenzonitrile

Mantsoe a tšoanang: 3-Cyano-4-Fluorobenzaldehyde

CAS: 218301-22-5

Bohloeki: ≥98.0%

Ponahalo: E Bosehla ho isa ho bosoeu bo Tiileng

Bohareng ba Olaparib (CAS: 763113-22-0) PARP-Inhibitor

Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com


Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale 2-Fluoro-5-Formylbenzonitrile
Litlhaloso tse tšoanang 3-Cyano-4-Fluorobenzaldehyde
Nomoro ea CAS 218301-22-5
Nomoro ea KAtse RF-PI451
Boemo ba Setoko Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule C8H4FNO
Boima ba Molek'hule 149.12
Melting Point 80.0 ho isa ho 84.0℃ (lit.)
Solubility E qhibiliha ka Methanol
Brand Ruifu Chemical

Litlhaloso:

Ntho Litlhaloso
Ponahalo Phofo e mosehla ho isa ho e tšoeu
Bohloeki ≥98.0%
Mongobo (KF) ≤0.50%
Litšila ka Kakaretso ≤2.0%
Tekanyetso ea Teko Maemo a Khoebo
Tšebeliso Bohareng ba Olaparib (CAS: 763113-22-0) PARP-Inhibitor

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard Drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo.

Melemo:

1

LBH:

Kopo:

2-Fluoro-5-Formylbenzonitrile (CAS: 218301-22-5) e sebelisetsoa ho lokisetsa metsoako ea heterocyclic e le PARP inhibitors bakeng sa tšebeliso ea meriana.2-Fluoro-5-Formylbenzonitrile e sebelisoa e le bohareng ba Olaparib (CAS: 763113-22-0).Olaparib ke inhibitor e nyane ea molek'hule ea PARP1/PARP2 (IC50: 5/1 nM) empa ha e sebetse hantle khahlano le PARP tankyrase-1 (IC50: 1.5 µM).Olaparib (AZD-2281, lebitso la khoebo Lynparza) ke kalafo e amohetsoeng ke FDA bakeng sa mofetše, e ntlafalitsoeng ke KuDOS Pharmaceuticals mme hamorao ke AstraZeneca.Ke PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), enzyme e amehang ho lokisoeng ha DNA. E sebetsa khahlanong le mofets'e ho batho ba nang le liphetoho tsa lefutso tsa BRCA1 kapa BRCA2, tse kenyelletsang mofets'e o mong oa mahe a bomme, matsoele le prostate.Ka Tšitoe 2014, olaparib e ile ea lumelloa ho sebelisoa e le moemeli a le mong ke EMA le FDA.Tumello ea FDA e mabapi le mofetše oa BRCA mutated (gBRCAm) o tsoetseng pele oa kankere ea mahe e fumaneng mela e meraro kapa ho feta ea chemotherapy.

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