5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Phepelo ea Vonoprazan Fumarate le ea Mahareng e Amanang
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Lebitso la Lik'hemik'hale | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| Litlhaloso tse tšoanang | Vonoprazan Fumarate (TAK-438) Ea Mahareng 3 |
| Nomoro ea CAS | 881674-56-2 |
| Nomoro ea KAtse | RF-PI330 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C11H8FNO |
| Boima ba Molek'hule | 189.19 |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Bosehla ho ea ho Phofo e Sootho |
| Melting Point | 122.0~131.0℃ |
| Boitsebiso: RT(HPLC) | Ikamahanye le Reference Standard |
| Tahlehelo ka ho Omisa | ≤0.50% |
| Residue On Ignition | ≤0.50% |
| Lintho Tse Amanang | |
| Bohloeki | ≥99.0% |
| Tšilafalo efe kapa efe e le 'Ngoe | ≤0.50% |
| Litšila ka Kakaretso | ≤1.0% |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Bohareng ba Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
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5-(2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) e sebetsa e le reagent ha ho etsoa litokisetso tsa "pyrrole derivatives" e le potassium-competitive acid blocker (P-CAB).5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde ke bohareng ba Vonoprazan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), e fumanoeng le ho ntlafatsoa ke Takeda le Otsuka, e amohetsoe ke PMDA ea Japane ka December 2014, 'me e bontšoa bakeng sa phekolo ea seso sa ka mpeng, seso sa duodenal le reflux esophagitis.Vonoprazan fumarate e na le mokhoa o mocha oa ts'ebetso o bitsoang li-blocker tsa potassium-competitive acid, tse thibelang ka tlholisano ho tlama li-ion tsa potasiamo ho H+, K+ -ATPase (eo hape e tsejoang e le pompo ea proton) mohatong oa ho qetela oa secretion ea asiti ea gastric ka har'a lisele tsa parietal tsa gastric.Vonoprazan ha e thibele mosebetsi oa Na +, K + -ATPase esita le ka makhetlo a 500 a phahameng ho feta a litekanyetso tsa bona tsa IC50 khahlanong le mosebetsi oa gastric H +, K + -ATPase.Ho feta moo, sethethefatsi ha se amehe ke boemo ba lekunutu ba gastric, ho fapana le li-PPI.
