5-Fluorocytosine (5-FC) CAS 2022-85-7 Bohloeki ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Mokhoa oa Tlhahlobo
Ponahalo-Bosoeu kapa Boebe bo Batla bo Bosoeu ba Crystalline
Tahlehelo ka ho Omisa-O e omise ka 105 bakeng sa lihora tse 4: ha e lahleheloe ke ho feta 1.50% ea boima ba eona.
Masala a ho Ignition - eseng ho feta 0.1%.
Heavy Metals - eseng ho feta 0.002%.
Fluoride - Kopanya 70 mL ea tharollo ea potassium chloride e sa tsoa lokisoa e nang le 30 ml ea joala ea isopropyl, tlatsa electrode ka supernatant e hlakileng, 'me u lumelle electrode ho lula ka har'a motsoako pele ho lihora tse 2 pele e sebelisoa, kapa ka ho khetheha bosiu bo le bong.
Ha u nka litekanyo, fetisetsa tharollo ho beaker ea 150-mL, 'me u qoelise li-electrode.Kenya tšisinyeho e entsoeng ka polytef ka har'a beaker, beha beake holim'a mochini oa makenete o nang le top insulated, 'me u lumelle ho sisinyeha ho fihlela tekano e fumaneha (hoo e ka bang metsotso e 1 ho isa ho e 2).Hlatsoa 'me u omise li-electrode pakeng tsa litekanyo, u hlokomele hore u se ke ua ngoaea kristale ka har'a electrode e khethehileng ea ion.
Lekanya bokhoni ba tokiso e 'ngoe le e 'ngoe ea Maemo, 'me u rere motsoako oa fluoride, ka mg ka 100 mL, khahlano le bokhoni, ka mV, pampiring ea semilogarithmic.Lekanya bokhoni ba boitokisetso ba Teko, 'me u bone ho tloha mokhoeng o tloaelehileng oa mahloriso a fluoride, ka mg ka 100 ml.Bala peresente ea fluoride karolong ea Flucytosine e nkiloeng ka foromo:
C / 10
moo C e leng mahloriso a fluoride, ka mg ka 100 mL, ho tloha moeling o tloaelehileng: ha ho 0.05% ea fluoride e fumanoang.
Fluorouracil-Dissolve 250 mg ka 10 ml ea motsoako oa glacial acetic acid le metsi (4:1).Kenya 20 µL ea tharollo ena poleiting e tšesaane ea chromatographic e tlositsoeng ka lera la 0.5-mm ea motsoako oa silika oa chromatographic.Ho poleiti e tšoanang sebelisa 20 µL, ka 10-µL increments, ea 0.025 mg ka mL tharollo ea USP Fluorouracil RS ka motsoako oa glacial acetic acid le metsi (4: 1).Ntlafatsa chromatogram ka motsoako oa chloroform le glacial acetic acid (13:7) ho fihlela karolo e ka pele ea solvent e sisinyehile ka tlase ho 14 cm ho tloha qalong.Tlosa poleiti ka phaposing e ntseng e tsoela pele, 'me u lumelle solvent hore e fetohe mouoane.Fumana matheba holim'a poleiti ka ho shebella ka tlas'a mahlaseli a mahlaseli a mahlaseli a mahlaseli a maqhubu a khutšoanyane: sebaka leha e le sefe se tsoang ho tharollo tlas'a teko ha se kholo ka boholo le ka matla ho feta sebaka sa RF e hlahisoang ke Standard solution, e sa feteng 0.1% ea fluorouracil.
Assay-Place e ka bang 400 mg ea Flucytosine, e lekantsoeng hantle, ka bekeng ea 250-mL, eketsa 150 ml ea motsoako oa 2 volumes ea glacial acetic acid le 1 volume ea acetic anhydride, 'me u qhale, u futhumale ha ho hlokahala.Titrate potentiometrically ka 0.1 N perchloric acid VS, ho sebelisa mochine oa motlakase oa khalase ea calomel.Etsa qeto e se nang letho, 'me u etse tokiso e hlokahalang.ML e 'ngoe le e' ngoe ea 0.1 N perchloric acid e lekana le 12.91 mg ea C4H4FN3O.Flucytosine e na le seng ka tlase ho karolo ea 98,5 lekholong le e seng ho feta 101.0 lekholong ea C4H4FN3O, e baloang motheong o omisitsoeng.