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7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate
Phepelo ea Moetsi, Boleng bo Phahameng, Tlhahiso ea Khoebo
Tolvaptan le li-intermediate tse amanang le tsona:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
| Lebitso la Lik'hemik'hale | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one |
| Litlhaloso tse tšoanang | 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one |
| Nomoro ea CAS | 160129-45-3 |
| Nomoro ea KAtse | RF-PI395 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C10H10ClNO |
| Boima ba Molek'hule | 195.65 |
| Melting Point | 103.0 ho isa ho 107.0 ℃ |
| Solubility | E qhibiliha ka Methanol |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Botala bo Khanyang ho ea ho Phofo e Sehla e Khanyang |
| Mekhoa ea ho Itsebahatsa | NMR, HPLC |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC) |
| Tahlehelo ka ho Omisa | ≤1.0% |
| Masalla a ho Ignition | ≤0.50% |
| Tšilafalo efe kapa efe e le 'Ngoe | ≤0.50% |
| Litšila ka Kakaretso | ≤1.0% |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Bohareng ba Tolvaptan (CAS 150683-30-0), phekolo ea Hyponatremia |
Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo.
7-Chloro-1,2,3,4-tetrahydrobenzo [b]azepin-5-one (CAS 160129-45-3) ke karolo e bohareng ea motsoako oa Tolvaptan (CAS 150683-30-0).Tolvaptan ke mohanyetsi ea khethang, ea nang le tlholisano ea molomo ea nonpeptide arginine vasopressin V2 receptor antagonist e nang le IC50 ea 1.28µM bakeng sa thibelo ea AVP-induced platelet aggregation.Tolvaptan e sebelisoa ho alafa hyponatremia e amanang le ho hloleha ha pelo, ho thatafala ha sebete le lefu la lihormone tse sa lokelang tsa antidiuretic.Tolvaptan o boetse o le litekong tsa bongaka tse potlakileng tsa lefu la liphio tsa polycystic.Kalafo e nang le Tolvaptan e fokotsa boima ba 'mele ka potlako le ka nako e ts'oanang le keketseho ea tlhahiso ea moroto, e ntlafatsa le / kapa e etsa hore sodium ea serum e tloaelehe ho bakuli ba hyponatremic, e fokotsa matšoao a tšubuhlellano le ho eketsa lenyora.
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