7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Purity >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory Featured Image

7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Bohloeki >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Tlhaloso e Khutšoanyane:

Lebitso: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

CAS: 53449-14-2

Bohloeki: >99.0% (HPLC)

Ponahalo: Bosehla bo Khanyang ho ea ho Phofo e Sootho e Khanyang

Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	7-Chloro-6-Nitro-4-Hydroxyquinazoline
Litlhaloso tse tšoanang	7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4(3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-one;7-Chloro-6-Nitroquinazolin-4 (3H) -e le 'ngoe
Nomoro ea CAS	53449-14-2
Nomoro ea KAtse	RF-PI2030
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C8H4ClN3O3
Boima ba Molek'hule	225.59
Kutloisiso	Mocheso o Mamela
Solubility	E qhibiliha hanyenyane ho Dimethylformamide
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e Bosehla bo Khanyang ho isa ho Bosootho bo Khanyang
Boitsebiso (HPLC)	Nako ea ho Boloka Mohlala e Lokela ho Tšoanang le Maemo
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)
Melting Point	300.0~303.0℃
Litaba tsa Metsi (KF)	<0.50%
Masalla a ho Ignition	<0.30%
Ho se hloeke 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
Ho se hloeke 2	<0.50% (5,7-Dichloro-4[1H]quinazolinone)
Ho se hloeke 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Tšilafalo e 'Ngoe	<0.20%
Litšila ka Kakaretso	<1.00%
Heavy Metals (as Pb)	<20ppm
Infrared Spectrum	E Ikamahanya le Sebopeho
Proton NMR Spectrum	Proton NMR Spectrum
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Afatinib, Afatinib Dimaleate

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) ke bohareng ba Afatinib Dimaleate (CAS: 850140-73-7).Afatinib ke lelapa le sa fetoheng la ErbB la li-blockers tse hatellang phetiso ea tlhahisoleseling le ho thibela litsela tse kholo tse amanang le kholo ea lisele tsa mofetše le karohano.Hobane mochine oa ho fetisetsa tlhahisoleseding ea lelapa la ErbB o ka hlahisoa ke li-homodimers tse ngata le li-heterodimers, ho thibela ka nako e le 'ngoe litho tse ngata tsa lelapa la ErbB (tse kang EGFR, HER2, ErbB3 le ErbB4) li ka sitisa ka katleho phetiso ea boitsebiso bo tlaase.Afatinib e sebelisoa ho phekola mofuta o itseng oa mofetše oa matšoafo (kankere e seng e nyane ea sele ea matšoafo) e hasaneng likarolong tse ling tsa 'mele.Ke ea sehlopha sa lithethefatsi tse tsejoang e le kinase inhibitors.E sebetsa ka ho fokotsa kapa ho emisa kholo ea lisele tsa mofetše.E tlama ho protheine e itseng (epidermal receptor-EGFR) ka har'a lihlahala tse ling.