7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3 Bohloeki>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Tlhaloso e Khutšoanyane:

Lebitso la Lik'hemik'hale: 7-Fluoro-6-Nitroquinazolin-4 (1H) -e 'ngoe

CAS: 162012-69-3

Bohloeki: >99.0% (HPLC)

Crystal e mosehla ho ea ho Bokhubetsoana bo mosehla kapa Phofo

Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Boleng bo Phahameng, Tlhahiso ea Khoebo

E-Mail: alvin@ruifuchem.com

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Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	7-Fluoro-6-Nitroquinazolin-4 (1H) -e le 'ngoe
Litlhaloso tse tšoanang	7-Fluoro-6-Nitroquinazolin-4 (3H) -e le 'ngoe;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-e le 'ngoe
Nomoro ea CAS	162012-69-3
Nomoro ea KAtse	RF-PI2025
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C8H4FN3O3
Boima ba Molek'hule	209.13
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Crystal e mosehla ho ea ho Bokhubetsoana bo mosehla kapa Phofo
1 H NMR Spectrum	E Lumellanang le Sebopeho
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)
Tahlehelo ka ho Omisa	<0.50%
Litšila ka Kakaretso	<1.00%
Proton NMR Spectrum	E Ikamahanya le Sebopeho
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe (CAS: 162012-69-3) ke bohareng ba Afatinib Dimaleate (CAS: 850140-73-7).Afatinib ke lelapa le sa fetoheng la ErbB la li-blockers tse hatellang phetiso ea tlhahisoleseling le ho thibela litsela tse kholo tse amanang le kholo ea lisele tsa mofetše le karohano.Hobane mochine oa ho fetisetsa tlhahisoleseding ea lelapa la ErbB o ka hlahisoa ke li-homodimers tse ngata le li-heterodimers, ho thibela ka nako e le 'ngoe litho tse ngata tsa lelapa la ErbB (tse kang EGFR, HER2, ErbB3 le ErbB4) li ka sitisa ka katleho phetiso ea boitsebiso bo tlaase.Afatinib ke sethethefatsi se amohetsoeng bakeng sa kalafo e seng e nyane ea cell lung carcinoma(NSCLC), e ntlafalitsoeng ke Boehringer Ingelheim.E sebetsa joalo ka angiokinase inhibitor.Joalo ka lapatinib le neratinib, afatinib ke tyrosine kinase inhibitor (TKI) eo hape e thibelang motho epidermal growth factor receptor 2 (Her2) le epidermal growth factor receptor (EGFR) kinases.Afatinib ha e sebetse feela khahlanong le liphetoho tsa EGFR tse lebisitsoeng ke moloko oa pele oa TKIs likeerlotinib kapa gefitinib, empa hape le khahlanong le ba sa tsotelleng mekhoa ena ea phekolo e tloaelehileng.Ka lebaka la ts'ebetso ea eona e eketsehileng khahlano le Her2, e ntse e batlisisoa bakeng sa mofetše oa matsoele hammoho le mefuta e meng ea mofets'e oa EGFR le Her2.