Adenosine CAS 58-61-7 Assay 99.0% -101.0% USP Standard Factory High Purity

Tlhaloso e Khutšoanyane:

Lebitso: Adenosine

CAS: 58-61-7

Ponahalo: Phofo e tšoeu ea Crystalline, e sa nkheng

Assay: 99.0% ~ 101.0% (ka motheo o omisitsoeng)

USP35 Standard, Boleng bo Phahameng, Tlhahiso ea Khoebo

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa ea Adenosine (CAS: 58-61-7) e nang le boleng bo phahameng, e kopana le maemo a USP, AJI97 standard.Ruifu Chemical e fana ka letoto la Nucleosides, Nucleotides, Nucleic Acids.Re ka fana ka lits'ebeletso tsa lefats'e ka bophara, tse nyane le tse ngata tse fumanehang.Haeba u thahasella Adenosine (CAS: 58-61-7), Please contact: alvin@ruifuchem.com

Lintho tsa Lik'hemik'hale:

Lebitso	Adenosine
Litlhaloso tse tšoanang	D-Adenosine;Adenosine, Free Base;Adenocard;Adenine Riboside;9-beta-D-Ribofuranosyladenine;9-β-D-Ribofuranosyladenine;6-Amino-9β-D-Ribofuranosyl-9H-Purine;6-Amino-9(β-D-Ribofuranosyl) -9H-Purine;Adenine-9-beta-D-Ribofuranoside
Nomoro ea CAS	58-61-7
Boemo ba Setoko	Ka Setokong, Bokhoni ba Tlhahiso Lithane tse 500 ka Selemo
Foromo ea limolek'hule	C10H13N5O4
Boima ba Molek'hule	267.25
Melting Point	233.0~238.0℃
E hloahloa	Ha A na Moeeng
Solubility	E qhibiliha hanyenyane ka metsing, e qhibiliha ka metsing a chesang, ha e khone ho qhibiliha ka har'a Ethanol (96 lekholong) le methylene Chloride.
Solubility ka Metsing a Chesang	Hoo e ka bang Ponaletso
Karolelano	Nucleosides, Nucleotides, Nucleic Acids
Brand	Ruifu Chemical

58-61-7 Lintlha tsa Tšireletseho:

Lipolelo tsa Kotsi	36/37/38	F	10-23
Lipolelo tsa Tšireletseho	24/25-36/37/39-26	TSCA	Ee
WGK Jeremane	2	Khoutu ea HS	2934993090
RTECS	AU7175000	Chefo	LD50 oral ho mouse:> 20gm/kg

Litlhaloso:

Lintho	Maemo a Tlhahlobo	Liphetho
Ponahalo	Phofo e Tšoeu ea Crystalline, e sa nkheng	E lumellana
Boitsebiso	IR e Ikamahanya le Reference	E lumellana
Phetoho e khethehileng [a]20/D	-68.0°～-72.0° (C=2 ho 5% NaOH)	-71.7°
Melting Point	233.0~238.0℃	235.0~236.0℃
Acidity kapa alkalinity	E Kopana le Litlhoko	E lumellana
Tahlehelo ka ho Omisa	≤0.50%	0.04%
Litšepe tse boima	≤10ppm	<10ppm
Masalla a ho Ignition	≤0.10%	0.08%
Moeli oa Ammonia	≤0.0004%	<0.0004%
Moeli oa Chloride	≤0.007%	<0.007%
Moeli oa Sulfate	≤0.02%	<0.02%
Guanosine	≤0.10%	Ho ba sieo
Insine	≤0.10%	0.01%
Uridine	≤0.10%	Ho ba sieo
Adenine	≤0.10%	Ho ba sieo
Litšila ka Kakaretso	≤0.50%	0.03%
Tlhahlobo	99.0 ~ 101.0% (ka motheo o omisitsoeng)	100.3%
Tekanyetso ea Teko	USP35 Standard	E lumellana
Lihlahisoa tse tlase	Adenosine triphosphate (ATP), Adenine, Adenylate, Adenosine Arabinose

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli, mongobo.Ha e lumellane le lisebelisoa tse matla tsa oxidizing.

58-61-7 USP35 Mokhoa oa Teko:

TLHALOSO
Adenosine e na le NLT 99.0% le NMT 101.0% ea C10H13N5O4, e baloang ho latela omisitsoeng.
TS'ELISO TS'OANE
• A. MONYAO OA INFORARED <197K>: NMT 0.1%
TLHOKOMELO
• ADENOSINE
Mohlala: 200 mg ea Adenosine e omisitsoeng pele ho 105 ° bakeng sa 2h
Sistimi ea Titrimetric
(Sheba Titrimetry <541>)
Mokhoa: Titration e tobileng
Titrant: 0.1 N ka chloric acid VS
Ho lemoha lintlha tsa ho qetela: Potentiometric
Tlhahlobo: Qhala ka 50 mL ea glacial acetic acid le titrate ka 0.1 N ka chloric acid VS.Bala liperesente tsa Adenosine (C10H13N5O4) karolong e nkiloeng:
Sephetho = [(V − B) × N × F × 100]/W
V = Mohlala oa molumo oa titrant (mL)
B = Bolumo e se nang letho (mL)
N= maemo a tloaelehileng (mEq/mL)
F= ntlha e lekanang: 267.25 mg/mEq
W= boima ba Mohlala (mg)
Mekhoa ea ho amohela: 99.0% -101.0% motheong o omisitsoeng
• DITSHILA
• HO KHANYA KA MASALE <281>: NMT 0.1%
• LITŠEPE TSE BOHLOKO, Mokhoa oa II <231>: NMT 10 ppm
• LIMELI TSA AMMONIA
Mohlala oa tharollo: Emisa 0.5 g ka 10 ml ea metsi.Hlohlelletsa 30 s, 'me u fetele ka har'a sefe e mahoashe.Hlakola filtrate ka metsi ho isa ho 15 ml, 'me u sebelise filtrate.
Tharollo e tloaelehileng: 0.4 µg/mL ea ammonium chloride metsing
Analysis: Ho Sample solution le Standard solution eketsa 0.3 mL ea alkaline mer curic-potassium iodide TS, koala li-tubes tsa teko, 'me u lumelle ho ema bakeng sa 5 min.
Mokhoa oa ho amohela: Tharollo ea Mohlala ha e bontše 'mala o mosehla o matla ho feta oa Tharollo e Tloaelehileng (NMT 4 ppm ea ammonia).
• LIMELI TSA CHLORIDE
Mohlala oa tharollo: Emisa 0.2 g ka 10 ml ea metsi.Hlohlelletsa 30 s, feta ka har'a sefe e mahoashe, 'me u sebelise filtrate.
Tharollo e tloaelehileng: 2.3 µg/mL ea sodium chloride metsing
Tlhahlobo: Ho Sample tharollo le 10 mL ea tharollo e Tloaelehileng eketsa 1 mL ea nitric acid le 1 mL ea silver nitrate TS, 'me u hlapolle tharollo ka' ngoe ka metsi ho 40 mL.Lumella litharollo ho ema metsotso e 5, e sirelelitsoe khanyeng.
Maemo a ho amohela: Ha e talingoa khahlano le bokamorao bo lefifi, Tharollo ea Mohlala ha e ferekane ho feta Tharollo e Tloaelehileng (NMT 0.007% chloride).
• LIMELI TSA SULFATE
Mohlala oa tharollo: Emisa 0.75 g ka 15 ml ea metsi.Hlohlelletsa 30 s, feta ka har'a sefe e mahoashe, 'me u sebelise filtrate.
Tharollo e tloaelehileng: Eketsa 0.15 mL ea 0.020 N sulfuric acid ho 15 mL ea metsi.
Tlhahlobo: Ho Sample tharollo le tharollo e Tloaelehileng eketsa 2 mL ea barium chloride TS le 1 mL ea 3 N hydrochloric acid, hlapolla tharollo ka 'ngoe ka metsi ho 30 mL, 'me u kopanye.Lumella litharollo ho ema bakeng sa 5 min.
Maemo a kamohelo: Tharollo ea Mohlala ha e ferekane ho feta Tharollo e Tloaelehileng (NMT 0.02% sulfate).
• LITŠILA TSA SEBELE
Tharollo A: 6.8 g/L ea potassium hydrogen sulfate le 3.4g/L ea tetrabutylammonium hydrogen sulfate metsing.Fetola ka 2 N potassium hydroxide ho pH ea 6.5.
Tharollo B: 0.1 g/L ea sodium azide solution
Mokhahlelo oa Mobile: Tharollo A le Tharollo B (60:40)
Tharollo ea ho tšoaneleha ha Sisteme: 0.2 mg/mL e 'ngoe le e 'ngoe ea Adenosine le inosine in Mobile phase
Mohlala oa tharollo: 1.0 mg/mL ea Adenosine ka Mobile phase
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Mokhoa: LC
Sesebelisoa: UV 254 nm
Kholomo: 4.6-mm × 25-cm;5-µm e paka L1
Sekhahla sa phallo: 1.5 mL / min
Boholo ba ente: 20 µL
Ho nepahala ha sistimi
Mehlala: Tharollo ea ho lekana ha sistimi
Litlhoko tsa ho tšoaneleha
Qeto: NLT 9.0 pakeng tsa adenosine le inosine
Ntlha ea ho qetela: NMT 2.5
Tekanyetso e amanang le maemo: NMT 2.0%
[HLOKOMELA-Chromatograph Tharollo ea Mohlala, 'me u fetole nako ea ho matha bonyane habeli ho feta nako ea ho boloka tlhoro e kholo.]
Tlhahlobo
Mohlala: Tharollo ea mohlala
Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Adenosine e nkiloeng:
Sephetho = (rU/rT) × 100
rU = tlhōrō ea karabo ea ho se hloeke ka 'ngoe ho tsoa ho Sample solution
rT = kakaretso ea likarabo tsa litlhōrō tsohle tse tsoang ho Sample solution
Mekhoa ea ho amohela
Litšila tsa motho ka mong: NMT 0.1% e 'ngoe le e 'ngoe ea guanosine, inosine, le uridine, le NMT 0.2% ea adenine
Kakaretso ea litšila: NMT 0.5%
LITEKO TSEKO
• LEKHALE LA HO QHOHOKA KAPA MOCHECHE <741>: 233°-238°
• PHETOHO EA MAIKUTLO, Phetoho e Khethehileng <781S>: -68° ho ea ho -72°
Tharollo ea teko: 20 mg/mL ka sodium hydroxide solution (1 ho 20), e khethiloeng ho sampole e neng e omisitsoe pele ho 105 ° bakeng sa 2h.
ACIDITY KAPA ALKALINITY: Emisa 1 g ho 20 ml ea metsi a se nang carbon dioxide.Hlohlelletsa 30 s, 'me u fetele ka har'a sefe e mahoashe.Ho e 'ngoe le e 'ngoe ea likarolo tse peli tsa 10-mL tsa filtrate eketsa 0.1mL ea bromocresol pherese TS.
Mekhoa ea ho amohela: NMT 0.3 mL ea 0.01 N sodium hydroxide e hlokahalang ho hlahisa 'mala o moputsoa-violet karolong e le' ngoe.NMT 0.1 mL ya 0.01 N hydrochloric acid e a hlokeha ho hlahisa mmala o mosehla karolong e nngwe.
•LOSSON DRYED <731>: Omisa sampole ka 105℃ bakeng sa 2 h: e lahleheloa ke NMT 0.5% ea boima ba eona.
KEKELETSO LIHLOKO
•PAKATSO LE HO BOLOKA: Boloka ka har'a lijalo tse thata, tse sa keneng khanya, 'me u li boloke mochesong o laolehileng oa kamore.
• LITEKELO TSA USP REFERENCE <11>
USP Adenosine RS

Melemo:

LBH:

Kopo:

Mosebetsi le Tšebeliso ea Adenosine (CAS: 58-61-7)
1. Adenosine ke protheine kinase activators.Ntlafatsa hypoxia ea myocardial, katoloso ea methapo ea methapo, ho eketsa konteraka ea myocardial, ho eketseha ha sekhahla sa pelo le litlamorao tse ling bakeng sa angina pectoris, acute myocardial infarction adjuvant therapy, empa karolo ea eona ea ho boloka nako e khuts'oane.E sebelisoa ho imolla angina le a hlobaetsang le a sa foleng myocardial infarction le mafu a mang.Adenosine e bapala karolo ea fisioloji tsamaisong ea pelo le methapo le litsamaiso tse ngata tsa 'mele.
2. Adenosine e sebelisoa ka synthesis adenosine triphosphate, adenosine (ATP), adenine, adenosine, li-intermediate tsa bohlokoa tsa vidarabine.Adenosine e sebelisoa haholo indastering ea meriana bakeng sa ho etsa adenosine;adenosine triphosphate;coenzyme le letoto la lihlahisoa tsa eona tse kang cyclic adenosine phosphate le lithethefatsi tse ling e le tsona tse ka sehloohong tse tala.
3. Adenosine e phetha karolo ea bohlokoa ho biochemistry, ho akarelletsa le adenosine triphosphate (ATP) kapa mofuta oa adeno-bisphosphate (ADP) oa phetisetso ea matla, kapa ho cyclic adenosine monophosphate (cAMP) bakeng sa ho fetisetsa lipontšo joalo-joalo.Ho phaella moo, adenosine ke neurotransmitter inhibitory (inhibitory neurotransmitter), e ka khothalletsa boroko.
4. Adenosine ke amino acid.Liphuputso li bontša bokhoni ba ho thibela wrinkles le ho thoba letlalo.Le hoja ho ngotsoe ho fokolang ka melemo ea eona e tobileng ea letlalo, adenosine e phetha karolo ea bohlokoa lits'ebetsong tsa lik'hemik'hale.Joalo ka adenosine triphosphate (ATP) le adenosine diphosphate (ADP), e ameha phetisong ea matla, hape e le cyclic adenosine monophosphate (cAMP) phetisong ea matšoao.
5. Adenosine ke lithethefatsi tse khahlanong le arrhythmic tse fetolang paroxysmal supraventricular tachycardia ho sinus rhythm.E sebelisoa bakeng sa arrhythmias ea supraventricular e amanang le atrioventricular.