Afatinib CAS 439081-18-2 Bohloeki >99.5% (HPLC) Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Afatinib

Mantsoe a tšoanang: BIBW2992

CAS: 439081-18-2

Bohloeki: >99.5% (HPLC)

Ponahalo: Phofo e Ntle-Bosoeu

E-Mail: alvin@ruifuchem.com

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Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Afatinib
Litlhaloso tse tšoanang	BIBW2992;BIBW-2992;BIBW2992 Free Base;Tomtovok;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(Dimethylamino)but-2-Enamide
Nomoro ea CAS	439081-18-2
Nomoro ea KAtse	RF-PI2033
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C24H25ClFN5O3
Boima ba Molek'hule	485.94
Solubility	E qhibiliha ka DMSO
Botenya	1.380
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e Ntle-Tšweu
Boitsebiso	HPLC, NMR
Mokhoa oa Bohloeki / Analysis	>99.5% (HPLC)
Melting Point	100.0 ~ 102.0℃
Tahlehelo ka ho Omisa	<0.50%
Masalla a ho Ignition	<0.20%
Litšila ka Kakaretso	<0.50%
Litšepe tse boima	≤20ppm
Sekhahla sa NMR	E Ikamahanya le Sebopeho
Tekanyetso ea Teko	Maemo a Khoebo
Shelf Life	Likhoeli tse 24 Haeba li Behiloe Hantle
Tšebeliso	API;Afatinib;Afatinib Dimaleate;NSCLC

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

Afatinib, eo hape e tsejoang e le BIW-2992, (CAS: 439081-18-2) ke moloko oa bobeli o matla le o ke keng oa fetoloa oa inhibitor ea epidermal growth factor receptor (EGFR) le human epidermal growth factor receptor 2 (HER2) tyrosine kinase, e ntlafalitsoeng ke Boehringer Ingelheim, Jeremane.E khona ho thibela mosebetsi oa tyrosine kinase ka mokhoa o ke keng oa fetoloa ka ho itšoara ka Michael le sehlopha sa thiol sa cysteine e boemong ba 797 ba EGFR.Ka la 12 Phupu, 2013, e ile ea fetoha setlhare se secha bakeng sa mofetše o monyane oa lisele tsa matšoafo o amohetsoeng ke US FDA tlasa lebitso la khoebo la Gilotrif.Setlhare sena ke letlapa.E sebelisoa bakeng sa kalafo ea bakuli ba fumanoeng ba e-na le mofetše oa metastatic o seng o nyane oa sele ea matšoafo (NSCLC) ka tahlehelo ea phetoho ea 19th exon kapa L858R ho 21th exon ea tumor epidermal growth factor receptor (EGFR) e netefalitsoeng ho sebelisoa kit e amohetsoeng. ka FDA.Setlhare sena se boetse se sebetsa hantle kalafong ea bakuli ba nang le HER2 ba nang le mofetše oa matsoele o tsoetseng pele.Afatinib ke ea sehlopha sa lithethefatsi tse tsejoang e le tyrosine kinase inhibitors.Tyrosine kinase inhibitors e etselitsoe ho thibela ketso ea enzyme e itseng e bitsoang tyrosine kinase.Enzyme ena e bapala karolo e kholo ts'ebetsong ea lisele, 'me e sebetsa ka mafolofolo ho holiseng le ho tsoela pele ha hlahala.Afatinib e sebetsa ho thibela tšebetso ea mefuta e 'meli ea tyrosine kinases: epidermal growth factor receptor (EGFR) le Her2, tse "hlahisoang ho feta" ke mefuta e mengata ea kankere.Ka ho thibela tšebetso ea tyrosine kinase tsena, Afatinib e ka thibela lisele tsa mofetše ho arohana le ho hola.