Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity >99.0% (HPLC) Factory Featured Image

Afatinib Dimaleate Intermediate CAS 314771-76-1 Bohloeki >99.0% (HPLC) Factory

Tlhaloso e Khutšoanyane:

Lebitso la Lik'hemik'hale: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Bohloeki: >99.0% (HPLC)

Ponahalo: Phofo e Bosehla bo Khanyang ho isa ho bosehla

Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Litlhaloso tse tšoanang	N4-(3-Chloro-4-Fluorophenyl) -7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Tšilafalo ea Afatinib B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Nomoro ea CAS	314771-76-1
Nomoro ea KAtse	RF-PI2028
Boemo ba Setoko	Ka Setokong, Bokhoni ba Tlhahiso 100MT / Selemo
Foromo ea limolek'hule	C18H16ClFN4O2
Boima ba Molek'hule	374.8
Ntlha e belang	559.0±50.0℃
Botenya	1.473±0.060 g/cm3
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Bosehla bo Khanyang ho isa ho Phofo e Sehla
Boitsebiso	Nako ea ho Boloka Peak e ka Sehloohong ho HPLC e Lokela ho Lumelana le Tekanyetso
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)
Tahlehelo ka ho Omisa	<0.50%
Masalla a ho Ignition	<0.20%
Tšilafalo e le Mong	<0.50%
Litšila ka Kakaretso	<1.00%
Heavy Metals (as Pb)	≤20ppm
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) ke bohareng ba Afatinib Dimaleate. (CAS: 850140-73-7).Afatinib ke moloko oa bobeli oa inhibitor e matla le e ke keng ea fetoloa ea epidermal growth factor receptor (EGFR) le human epidermal growth factor receptor 2 (HER2) tyrosine kinase, e entsoeng ke Boehringer Ingelheim, Jeremane.E khona ho thibela mosebetsi oa tyrosine kinase ka mokhoa o ke keng oa fetoloa ka ho itšoara ka Michael le sehlopha sa thiol sa cysteine e boemong ba 797 ba EGFR.Mosebetsi: 1. Joalo ka Lapatinib le Neratinib, Afatinib ke protheine kinase inhibitor eo hape e thibelang ka mokhoa o ke keng oa qojoa e thibela motho epidermal growth factor receptor 2 (Her2) le epidermal growth factor receptor (EGFR) kinases.2. Afatinib ha e sebetse feela khahlanong le liphetoho tsa EGFR tse lebisitsoeng ke TKI ea moloko oa pele joaloka erlotinib kapa gefitinib, empa hape le khahlanong le liphetoho tse kang T790M tse sa tsotelleng mekhoa ena ea phekolo e tloaelehileng.Ka lebaka la ts'ebetso ea eona e eketsehileng khahlano le Her2, e ntse e batlisisoa bakeng sa mofetše oa matsoele hammoho le mefuta e meng ea mofets'e oa EGFR le Her2.3. Afatinib ke lithethefatsi bakeng sa phekolo ea pele ea bakuli ba nang le mefuta e sa tšoaneng ea metastatic (EGFR mutation positive) e seng e nyenyane cell lung carcinoma (NSCLC).E sebetsa e le inhibitor e ke keng ea fetoloa ea covalent ea receptor tyrosine kinases epidermal growth factor receptor (EGFR) le erbB-2 (HER2).