Atazanavir CAS 198904-31-3 Purity ≥99.0% API Factory Anti-HIV HIV-1 Protease Inhibitor

Atazanavir (CAS 198904-31-3) ke sethethefatsi sa antiretroviral, novel le azapeptide e matla ea sehlopha sa protease inhibitor (PI).E rekisoa tlas'a lebitso la khoebo Reyataz.Joalo ka li-antiretrovirals tse ling, e sebelisoa ho phekola tšoaetso ea mofuta oa 1 oa HIV-1 (HIV-1) protease enzyme e nang le inhibition kamehla Ki ea 66 nmol/L hape e thibela ho ikatisa ha kokoana-hloko ea HIV-1 ka 50% e sebetsang hantle ea EC50 ho tloha 2.6 ho isa ho 5.3 nmol/L.Atazanavir e tlama ho HIV-1 protease e thibelang ho petsoha ha gag le gag-pol polyprotein, e leng se fellang ka hore ho thehoe li-virion tse sa pheleng liseleng tse nang le tšoaetso ea HIV-1.Atazanavir e na le sebopeho sa lik'hemik'hale se fapaneng sa C-2 le matla a antiretroviral ka kakaretso mefuta e fapaneng ea HIV ha e bapisoa le li-protease inhibitors tse ling, ho kenyeletsoa Indinavir, Nelfinavir, Ritonavir, Saquinavir le Amprenavir.Atazanavir e khetholloa ho li-PI tse ling ka hore e ka fanoa hang ka letsatsi 'me e na le litlamorao tse nyane ho boemo ba lipid ba mokuli.Joalo ka li-protease inhibitors tse ling, e sebelisoa feela hammoho le meriana e meng ea HIV.Atazanavir ke mofuta o mocha oa azapeptide HIV protease inhibitor.Antiviral.E nkoa ka molomo hang ka letsatsi.