Baloxavir Marboxil CAS 1985606-14-1 API Factory High Quality

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Baloxavir Marboxil

CAS: 1985606-14-1

Ponahalo: Phofo e tšoeu ho isa ho e tšoeu

Tekanyo: 98.0% ~ 102.0%

Kalafo ea Influenza A le Influenza B Infections

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Baloxavir Marboxil (CAS: 1985606-14-1) ka boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Baloxavir Marboxil
Litlhaloso tse tšoanang	BXM;S-033188
Nomoro ea CAS	1985606-14-1
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C27H23F2N3O7S
Boima ba Molek'hule	571.55
Botenya	1.57±0.10 g/cm3
Solubility	E qhibiliha ka DMSO
Polokelo ea Nako e telele	Boloka Nako e telele ho -20 ℃
COA & MSDS	E fumaneha
Tšimoloho	Shanghai, China
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu ho isa ho e tšoeu
Boitsebiso	IR Spectrum e lumellana le litekanyetso tsa litšupiso Nako ea ho boloka e lumellana le maemo a referense
Litaba tsa Metsi (ka KF)	≤1.0%
Tahlehelo ka ho Omisa	≤1.0%
Masalla a ho Ignition	≤0.50%
Litšepe tse boima	≤20ppm
Lintho Tse Amanang
Ho se hloeke ho hoholo hoa Motho ka Mong	≤0.50%
Litšila ka Kakaretso	≤1.0%
Boholo ba Karolo	D90 Pass 150um
Chiral Purity	≥99.0%
Bohloeki	≥99.0%
Tlhahlobo	98.0%~102.0%
Metsoako e setseng	Latela Litlhoko tsa ICH
Ho tsamaisa ka sekepe	Ho Romella ka Ice Pack
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API, kalafong ea Influenza A le Influenza B Infections

Sephutheloana le Bobolokelo:

Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.

Melemo:

LBH:

1985606-14-1 - Kopo:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) ke moriana o thibelang likokoana-hloko o entsoeng ke Shionogi Co., k'hamphani ea meriana ea Japane le Roche bakeng sa phekolo ea mafu a feberu A le ntaramane ea B.Setlhare sena se ile sa lumelloa ho sebelisoa Japane ka Hlakola 2018 mme sa amoheloa ke FDA ka la 24 Mphalane, 2018 bakeng sa kalafo ea ntaramane e matla e sa rarahanang ho bakuli ba lilemo tse 12 le ho feta ba bileng le matšoao bakeng sa lihora tse fetang 48 Label.Baloxavir marboxil, cap-endonuclease inhibitor, e na le mokhoa o ikhethileng oa ts'ebetso ha o bapisoa le sehlopha se teng hona joale sa neuraminidase inhibitor se sebelisoang ho alafa tšoaetso ea ntaramane.Baloxavir Marboxil ke setlhare se secha se thibelang ntaramane se nang le mokhoa o mocha oa tšebetso.Baloxavir Marboxil ke sehlahiswa sa Baloxavir Acid (S-033447) se thibelang ka matla le ka boikgethelo endonuclease e itshetlehileng ka hare ho polymerase PA subunit ya divaerase tsa ntaramane A le B, e leng se lebisang ho thibeleng ho ngoloa ha RNA le ho ikatisa.Baloxavir e boetse e batlisisitsoe ka bokhoni ba eona ba ho phekola COVID-19 empa ha ho molemo o netefalitsoeng o bonoang.

1985606-14-1 - Mokhoa oa Ts'ebetso:

Baloxavir Marboxil ke moemeli oa kalafo ea ntaramane, haholo-holo, enzyme inhibitor e shebileng ts'ebetso e itšetlehileng ka vaerase ea ntaramane, e leng e 'ngoe ea mesebetsi ea vaerase ea polymerase complex.Haholo-holo, e thibela ts'ebetso e tsejoang ka hore ke "cap snatching", eo ka eona kokoana-hloko e fumanang li-primers tse khutšoane, tse koaletsoeng ho tsoa ho lingoliloeng tsa RNA, tseo e li sebelisang bakeng sa motsoako oa polymerase-catalyzed oa li-mRNA tsa eona tse hlokahalang.Polymerase subunit e hokahana le pre-mRNAs e amohelang li-pre-mRNA ka li-caps tsa 5', ebe ts'ebetso ea polymerase endonuclease e etsa hore e arohane "ka mor'a 10-13 nucleotide".Ka hona, mochine oa eona o fapane le li-inhibitors tsa neuraminidase tse kang Oseltamivir le Zanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil is selective inhibitor of influenza cap-dependent endonuclease e thibelang mosebetsi wa polymerase mme ka hona kokoana-hloko ea ntaramane mRNA replication 5, 3. E bontšitse tšebetso ea phekolo khahlanong le tšoaetso ea kokoana-hloko ea A le B, ho kenyelletsa le mefuta e hanyetsanang le li-antiviral tsa hona joale. e thibela enzyme e hlokahalang bakeng sa ho ikatisa ha kokoana-hloko, kahoo e phekola tšoaetso ea kokoana-hloko ea ntaramane ka potlako 5, Label le ho fokotsa matšoao a amanang le tšoaetso.Tekanyetso e le 'ngoe ea moemeli ena e bontšitsoe e phahametse placebo ho imolla matšoao a ntaramane le ho feta seltamivir le sethethefatsi sa placebo ka liphello tsa virologic (tse tšoailoeng ka ho fokotseha ha bongata ba kokoana-hloko).

1985606-14-1 - Lipontšo:

Baroxavir e loketse bakuli ba ≥ lilemo tse 12 ba tšoeroeng ke ntaramane e matla e sa rarahanang le bao matšoao a bona a sa feteng lihora tse 48.Ela hloko mefokolo ea meriana: kokoana-hloko ea feberu e fetoha ha nako e ntse e ea, 'me ho na le lintlha tse kang mofuta oa kokoana-hloko le subtype.Hang ha ho hanyetsa lithethefatsi tsa kokoana-hloko le pathogenicity ea kokoana-hloko e fetoha, katleho ea meriana ea meriana e thibelang likokoana-hloko e ka fokotsoa.Ha ho etsoa qeto ea ho nka basalovir dipivoxil, tlhahisoleseling e teng mabapi le kutloelo-bohloko ea mofuta oa kokoana-hloko ea seoa ea lehae ho sethethefatsi e lokela ho nahanoa.

1985606-14-1 - Lisebelisoa:

Baloxavir Marboxil ke moriana oa ntaramane, antiviral, e nooang e le letlapa le le leng, ka molomo, ke batho ba lilemo li 12 kapa ho feta, ba hlahisitseng matšoao a ts'oaetso ena nako e fetang lihora tse 48. baloxavir marboxil e tsamaisoang kamora lihora tse 48 ha e so hlahlojoe.

1985606-14-1 - Contraindications:

Baloxavir Marboxil ha ea lokela ho sebelisoa hammoho le lihlahisoa tsa lebese, lino tse nang le calcium e matlafalitsoeng, kapa li-laxatives, li-antacids, kapa li-supplement tsa molomo tse nang le calcium, tšepe, magnesium, selenium, aluminium kapa zinki.

1985606-14-1 - Litlamorao:

Litla-morao tse tloaelehileng tse latelang tekanyetso e le 'ngoe ea baloxavir marboxil li kenyelletsa letšollo, bronchitis, sefuba se tloaelehileng, hlooho e opang le ho nyekeloa ke pelo.Liketsahalo tse mpe li tlalehiloe ho 21% ea batho ba amohetseng baloxavir, 25% ea ba fumanang placebo, le 25% ea Oseltamivir.

1985606-14-1 - Tokisetso:

Patent ea Japane JP6212678 e tlalehile mokhoa oa ho kopanya oa Baloxavir Marboxil.3, 4-difluorobenzoic acid e ne e sebelisoa e le lisebelisoa tse tala ho itšoara ka DMF tlas'a ketso ea LDA ho fumana 2-formyl-3, 4-difluorobenzoic acid.Ebe e theha thioacetal le thiophenol, ebe e fokotseha ebe e aroloa ka borane ho fumana 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11 (6H) -e 'ngoe,' me qetellong karolo ea bohlokoa ea thiazepine 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-alcohol e fumanoa tlas'a ho fokotseha ha sodium borohydride.Ho sebelisa 3-(benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid ho itšoara ka tert-butyl formate ka mor'a esterification ho fumana 3-(benzyloxy) -1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, ebe ka 2-(2, 2-dimethoxyethoxy) ethylamine e kena karabelo ea phapanyetsano ea urethane, ebe e tsamaea ka tlas'a ketso ea methanesulfonic acid ho fumana 7-(benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f] [1,2,4] triazine -6, 8-dione hemihydrate, joale ke condensed le (R) -tetrahydrofuran -2-formic acid, ebe crystallized le ho rarolloa, 'me joale sehlopha se thusang chiral se tlosoa ho fumana senotlolo chiral motsoali lesale molek'hule (R) -7-(benzyloxy) -3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f] [1,4] Triazine-6, 8-dione.Joale molek'hule ea bohlokoa ea lesale ea motsoali e sebelisetsoa ho fapanyetsana le n-hexanol tlas'a ts'ebetso ea Grignard reagent, ebe ka karoloana ea bohlokoa ea thiazepine 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-alcohol docking. , 'me qetellong ea debutylation le condensation ka methyl chloroformate ho fumana sehlahisoa sa ho qetela Baloxavir Marboxil.