Betamethasone CAS 378-44-9 Purity 97.0%~103.0% API Factory High Purity

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Betamethasone

CAS: 378-44-9

Ponahalo: Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu

Bohloeki: 97.0% ~ 103.0% ea C22H29FO5, ka mokhoa o omisitsoeng

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Li-tag tsa Sehlahisoa

378-44-9 - Tlhaloso:

Phepelo ea Khoebo Betamethasone e nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Betamethasone
CAS: 378-44-9

378-44-9 -Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Betamethasone
Litlhaloso tse tšoanang	Betamethasone Base;9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione;(11beta,16alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
Nomoro ea CAS	378-44-9
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C22H29FO5
Boima ba Molek'hule	392.47
Melting Point	235.0~237.0℃
Boemo ba ho Romela	Tlas'a Mocheso oa Ambient
COA & MSDS	E fumaneha
Brand	Ruifu Chemical

378-44-9 -Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu
Boitsebiso A	Ho kenngoa ha infrared
Boitsebiso B	Teko ea Boitsebiso ea Thin-Layer Chromatographic
Specific Optical Rotation	+118.0 ° ho ea +126.0 ° (E baloa ka Motheo o Omisitsoeng)
Tšilafalo ea Motho ka Mong	≤1.00%
Litšila ka Kakaretso	≤2.00%
Methanol e setseng e qhibilihisa	≤3000ppm
Metsoako e setseng ea Chloroform	≤60ppm
Tahlehelo ka ho Omisa	≤0.50% (E omise ho 105 ℃, lihora tse 3)
Masalla a ho Ignition	≤0.20%
Mokhoa oa Bohloeki / Analysis	97.0%~103.0% ea C22H29FO5 E Baloang ka Motheo o Omisitsoeng
Tekanyetso ea Teko	Pharmacopoeia ea Chaena (CP);EP10.0 le USP 42
Ho paka le ho Boloka	Boloka ka lijaneng tse thata.Boloka pakeng tsa 2℃ le 30℃ .
Kopo	Active Pharmaceutical ingredient (API)

Sephutheloana le Bobolokelo:

Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~30℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Lula hole le leseli le matla le mocheso, mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.

Melemo:

LBH:

378-44-9 - Kotsi le Tšireletseho:

Likhoutu tsa Kotsi R40 - Bopaki bo fokolang ba phello ea kankere
R48/20/21 -
R61 - E ka baka kotsi ho ngwana ya esong ho hlahe
Tlhaloso ea Tšireletseho S22 - U se ke ua hema lerōle.
S36 - Apara liaparo tse loketseng tsa tšireletso.
S45 - Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ho ngaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S53 - Qoba ho pepeseha - fumana litaelo tse khethehileng pele u li sebelisa.
WGK Jeremane 2
RTECS TU4000000
HS Code 2937229000
Chefo LD50 ka molomo ho toeba:> 4500mg/kg

378-44-9 -Kopo:

Betamethasone (CAS: 378-44-9), ke ea adrenal corticosteroids, ke isomer ea dexamethasone, 'me karolo ea betamethasone e tšoana le prednisolone le dexamethasone, e na le anti-inflammatory, anti-rheumatic, anti-allergic le khatello ea kelello. ea 'mele oa ho itšireletsa mafung le liphello tse ling tsa meriana, phello ea eona e khahlanong le ho ruruha e matla ho feta dexamethasone, triamcinolone, hydrocortisone joalo-joalo, e ka fokotsa le ho thibela karabelo ea lisele ho ruruha le ho felisa mocheso, bofubelu le ho ruruha ho bakoang ke ho ruruha ho sa tšoaetsanoeng sebakeng seo, kahoo ho fokotsa ho ruruha. ts'ebetso ea ho ruruha, phello e khahlanong le ho ruruha ea sehlahisoa sena 0.3mg e lekana le dexamethasone 0.75mg, prednisone 5mg kapa 25mg cortisone.Betamethasone sodium retention effect e feta ka makhetlo a lekholo ho feta hydrocortisone, in primary adrenal hypofunction, e ka sebelisoa hammoho le glucocorticoid bakeng sa phekolo e ncha, 'me e sebelisetsoa ho thibela kapa ho thibela karabelo ea 'mele ea ho itšireletsa mafung ka lisele, ho liehisa ho itšoara hantle le ho fokotsa sesole sa mantlha. Katoloso ea karabelo, e sebelisoa bakeng sa renin e tlase le lefu le tlase la aldosterone le autonomic neuropathy e bakoang ke orthostatic hypotension.Hona joale betamethasone e boetse e sebelisoa bakeng sa phekolo ea ramatiki ea ramatiki, ramatiki ea ramatiki, lupus, asthma e matla ea bronchial, dermatitis e matla, kankere e matla ea mali, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis le pruritus le phekolo e feletseng ea mafu a itseng.Sehlahisoa sena se hanyetsanoa historing e matla ea kelello, seso se sebetsang sa duodenal, anastomosis ea morao tjena ea gastrointestinal, lefu la ho fokola ha masapo, lefu la tsoekere le feteletseng, khatello ea kelello e matla, kokoana-hloko , likokoana-hloko, mafu a fungal a hlōlehileng ho laola ka tšebeliso ea li-antimicrobial agents , thrombophlebitis, mafu a letlalo, joalo-joalo. joalo ka impetigo, tinea, jock itch joalo-joalo.

378-44-9 - USP35 Standard:

Betamethasone
C22 H29FO5 392.46
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16) -.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone e na le liphesente tse seng ka tlase ho 97.0 mme ha li fete liperesente tse 103.0 tsa C22H29FO5, tse baloang ho latela omisitsoeng.
Ho paka le ho boloka-Ho boloka ka lijaneng tse thata.Boloka pakeng tsa 2℃ le 30℃.
USP Reference standards <11>-
USP Betamethasone RS
Boitsebiso-
A: Infrared Absorption <197M>.
B: Thin-Layer Chromatographic Identification Test <201>-
Tharollo ea teko-Lokisetsa tharollo ea Betamethasone ka joala bo se nang metsi bo nang le 0.5 mg ka mL.
Ho ntshetsa pele tsamaiso ea solvent: motsoako oa chloroform le diethylamine (2: 1).
Ts'ebetso-Tsoela pele joalo ka ha ho laetsoe khaolong, ntle le ho fumana matheba ka ho fafatsa hanyenyane ka dilute sulfuric acid (1 ho 2) le ho futhumatsa ka poleiti e chesang kapa ka tlas'a lebone ho fihlela matheba a hlaha.
Potoloho e khethehileng <781S>: pakeng tsa +118 le +126, e baloang ka motheo o omisitsoeng.
Tharollo ea teko: 5 mg ka mL, ka methanol.
Tahlehelo ha o omisa 731-E omise ho 105 bakeng sa lihora tse 3: ha e lahleheloe ke ho feta 1.0% ea boima ba eona.
Masala a ho khantša 281: eseng ho feta 0.2%, ho sebelisoa crucible ea platinum.
Litšila tse tloaelehileng 466-
Tharollo ea liteko: methanol.
Tharollo e tloaelehileng: methanol.
Bophahamo ba kopo: 10 µL.
Eluant: motsoako oa toluene, acetone, methyl ethyl ketone, le formic acid (55:20:20:5), ka kamoreng e sa tsitsang.
Pono: 5.
Tlhahlobo-
Mohala oa selefouno-Lokisetsa motsoako o hloekisitsoeng le o senyehileng oa metsi le acetonitrile (63:37).Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Tharollo e tloaelehileng ea ka hare-Lokisetsa tharollo ea propylparaben joala e nang le motsoako o ka bang 0.25 mg ka mL.
Tlhophiso e tloaelehileng-Hlakola tekanyo e lekantsoeng e nepahetseng ea USP Betamethasone RS ka joala ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 0.2 mg ka mL.Fetisetsa 10.0 mL ea tharollo ena ho vial e loketseng, 'me u kenye 10.0 mL ea Internal standard solution, ho fumana Tokiso e Tloaelehileng e nang le likhakanyo tse tsejoang tsa hoo e ka bang 0.1 mg ea betamethasone le hoo e ka bang 0.125 mg ea propylparaben ka mL.
Boitokisetso ba tlhahlobo-Ho sebelisa hoo e ka bang 80 mg ea Betamethasone, e lekantsoeng hantle, lokisetsa ho ea ka taelo ea ho lokisetsa Standard.
Chromatographic system (sheba Chromatography 621) -Mokelikeli oa chromatograph o na le mochine oa 240-nm le kholomo ea 4.6-mm × 25-cm e nang le ho paka L1.Sekhahla sa phallo ke hoo e ka bang 1.0 mL ka motsotso.Chromatograph ea Boitokisetso ba Maemo, le ho tlaleha likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: linako tse lekanyelitsoeng tsa ho boloka li ka ba 1.0 bakeng sa betamethasone le 1.4 bakeng sa propylparaben;qeto, R, pakeng tsa betamethasone le propylparaben ha e ka tlaase ho 3.0;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang ha e fete 2.0%.
Ts'ebetso-Ka karohano kenya li-volume tse lekanang (tse ka bang 10 µL) tsa tokisetso e tloaelehileng le boitokisetso ba Assay ho chromatograph, rekota li-chromatogram, 'me u lekanye likarabo tsa litlhoro tse kholo.Bala palo, ka mg, ea C22H29FO5 karolong ea Betamethasone e nkiloeng ka foromo:
800C(RU / RS)
eo ho eona C e leng mahloriso, ka mg ka mL, ea USP Betamethasone RS ho tokisetso e tloaelehileng;'me RU le RS ke likarolelano tsa bophahamo ba tlhōrō ea tlhōrō ea betamethasone le tlhōrō ea maemo a ka hare e fumanoang ho tsoa ho Tokiso ea Assay le Tokisetso ea Maemo, ka ho latellana.