Candesartan Cilexetil CAS 145040-37-5 Purity >99.0% (HPLC) API Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Candesartan Cilexetil

CAS: 145040-37-5

Bohloeki: >99.0% (HPLC)

Ponahalo: Bosoeu ho isa ho Bosoeu ba Crystalline Powder

Mohanyetsi ea khethiloeng oa Angiotensin II Receptor

API Boleng bo Phahameng, Tlhahiso ea Khoebo

E-Mail: alvin@ruifuchem.com

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Tlhaloso:

Ruifu Chemical Supply Candesartan Cilexetil Intermediate Ka Bohloeki bo Phahameng
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Ea Hare Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
Trityl Candesartan Cilexetil CAS 170791-09-0

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Candesartan Cilexetil
Litlhaloso tse tšoanang	TCV-116;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H -benzo [d] imidazole-7-Carboxylate
Nomoro ea CAS	145040-37-5
Nomoro ea KAtse	RF-PI1891
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C33H34N6O6
Boima ba Molek'hule	610.66
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo ea Crystalline e tšoeu ho isa ho e tšoeu
Boitsebiso ba HPLC	Nako ea ho boloka tlhoro e kholo ea chromatogram ea sampole e lumellana le e ho chromatogram e fumanoeng ka maemo.
Boitsebiso ba IR	Sekhahla sa infrared infrared absorption spectrum se ts'oana le sa Candesartan Cilexetil standard standard.
Ho Hlakola le Tharollo ea Mebala	Tharollo ka chloroform ho 5% e hlakile ebile ha e na mebala
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)
Melting Point	155.0 ~ 160.0℃
Tahlehelo ka ho Omisa	<0.30%
Masalla a ho Ignition	<0.10%
Litšepe tse boima	<10ppm
Arsenic (As)	<1ppm
Kabo ea boholo ba Particle	90% <30 μm
Litšila tsa Organic	ka HPLC
Ethyl Candesartan	<0.15%
Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Tšilafalo efe kapa efe e sa Tsejoeng	<0.15%
Litšila ka Kakaretso	<0.60%
Tlhahlobo ea Potentiometry	99.0 ~ 101.0% ea C33H34N6O6, e baloang ka ntho e anhydrous
Ho se hloeke ha Organic Volatile
Methano	<0.30%
Ethanol	<0.50%
Diethyl Ether	<0.50%
Aceton	<0.50%
Dichloromethan	<0.06%
Dimethylformamide	<0.088%
Tšilafalo ea Microbiological
Kakaretso ea Aerobic Microbial Count	<1000cfu/g
Hlobo le Litomoso	<100cfu/g
E.Coli	Absent
Salmonella	Absent
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API;Moemeli oa Antihypertensive

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) ke mohanyetsi oa angiotensin II receptor le IC50 ea 0.26 nM, e sebelisoang ho phekola khatello ea kelello ea mali.Candesartan ke angiotensin-receptor blocker (ARB) e ka sebelisoang e le mong kapa le mahlahana a mang ho alafa khatello ea mali.E tsamaisoa ka molomo e le prodrug, candesartan cilexetil, e fetoloang ka potlako ho metabolite ea eona e sebetsang, candesartan, nakong ea ho kenella ka mpeng ea mpa.Candesartan e theola khatello ea mali ka ho hanyetsa tsamaiso ea renin-angiotensin-aldosterone (RAAS);e qothisana lehlokoa le angiotensin II bakeng sa ho tlama mofuta oa mofuta oa 1 angiotensin II receptor (AT1) mme e thibela litlamorao tse ntseng li eketseha tsa khatello ea mali ea angiotensin II.Ho fapana le li-angiotensin-converting enzyme (ACE) inhibitors, li-ARB ha li na phello e mpe ea sefuba se omileng.Candesartan e ka sebelisoa ho phekola khatello e phahameng ea mali, khatello ea mali e ikhethileng ea systolic, hypertrophy ea ventricular ea le letšehali le nephropathy ea lefu la tsoekere.E ka boela ea sebelisoa e le mokhoa o mong oa ho phekola lefu la pelo, ho se sebetse ha systolic, infarction ea myocardial le lefu la methapo ea pelo.