Carvedilol CAS 72956-09-03 Bohloeki >99.0% (HPLC)

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Carvedilol

CAS: 72956-09-03

Bohloeki: >99.0% (HPLC)

Ponahalo: Phofo e tšoeu ea Crystalline

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Carvedilol (CAS: 72956-09-03) ka boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Carvedilol,Please contact: alvin@ruifuchem.com

Li-Intermediate tse Amanang:

Li-Intermediate tse Amanang tsa Carvedilol

N-(2-(2-Methoxyphenoxy)ethyl)benzylamine Hydrochloride	CAS: 3246-03-5
2-(2-Methoxyphenoxy) ethylamine Hydrochloride Hydrate	CAS 64464-07-9
2-(2-Methoxyphenoxy)ethylamine	CAS 1836-62-0
4-(2,3-Epoxypropoxy)carbazole	CAS 51997-51-4
4-Hydroxycarbazole	CAS 52602-39-8
1,3-Cyclohexanedione	CAS 504-02-9
"Carvedilol"	CAS 72956-09-03
Carvedilol Phosphate Hemihydrate	CAS 610309-89-2

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	"Carvedilol"
Litlhaloso tse tšoanang	1-(9H-Carbazol-4-yloxy) -3-[[2-(2-Methoxyphenoxy)ethyl]amino] -2-Propanol;Moetsi oa litšoantšo;Cadilan;Carca;Carivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Boemo ba Setoko	Ka Stock, GMP Commercial
Nomoro ea CAS	72956-09-3
Foromo ea limolek'hule	Setšoantšo sa C24H26N2O4
Boima ba Molek'hule	406.48 g/mol
Melting Point	115.0 ho isa ho 119.0 ℃
Botenya	1.250±0.06 g/cm3
Sollubility ka Metsing	Ha e qhibilihe ka Metsing
Solubility	E qhibiliha ka Methanol.E qhibiliha hanyenyane ka Ethanol, Ether
Mocheso oa polokelo.	Sebaka se pholileng le se omileng (2~8℃)
COA & MSDS	E fumaneha
Brand	Ruifu Chemical

Litlhaloso:

Lintho	Maemo a Tlhahlobo	Liphetho
Ponahalo	Phofo e Tšoeu ea Crystalline	E lumellana
Tahlehelo ka ho Omisa	≤0.50% (105℃ bakeng sa 3 h)	0.25%
Masalla a ho Ignition	≤0.10%	0.07%
Lintho Tse Amanang
Litšila ka Kakaretso	≤0.50%	E lumellana
Tšilafalo A	≤0.20%	E lumellana
Tšilafalo C	≤0.02%	E lumellana
Tšilafalo Efe E 'ngoe ea Motho ka Mong	≤0.10%	E lumellana
Litšepe tse boima (Pb)	≤10ppm	<10ppm
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)	99.72%
Infrared Spectrum	E Ikamahanya le Sebopeho	E lumellana
Qetello	Sehlahisoa se lekoa 'me se lumellana le litlhaloso

Sephutheloana/Bobolokelo/Ho tsamaisa ka sekepe:

Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka setshelo se koetsoeng ka thata.Boloka sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.

Melemo:

Bokhoni bo lekaneng: Lisebelisoa le litsebi tse lekaneng

Tšebeletso ea profeshenale: Tšebeletso e le 'ngoe ea ho reka

Sephutheloana sa OEM: Sephutheloana sa tloaelo le leibole lia fumaneha

Tlhahiso e potlakileng: Haeba e le ka har'a setoko, ho netefalitsoe hore ho tsamaisoa matsatsi a mararo

Thepa e tsitsitseng: Boloka thepa e lekaneng

Tšehetso ea Theknoloji: Tharollo ea theknoloji e teng

Tšebeletso e Tloaelehileng ea ho Kopanya: Ho tloha ho ligrama ho isa ho lik'hilograma

Boleng bo Phahameng: Ho thehile tsamaiso e felletseng ea netefatso ea boleng

LBH:

Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.

Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.

Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.

BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.

Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.

Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.

MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.

Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.

Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.

Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.

Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.

Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.

72956-09-3 - Boitsebiso ba Polokeho:

Likhoutu tsa Kotsi N,Xn
Lipolelo tsa Kotsi 51/53-36/37/38-20/21/22
Lipolelo tsa Tšireletso 61-36-26
RIDADR UN 3077 9/PG 3
WGK Jeremane 3
RTECS UA8670000
HazardClass TSOHLE
Packing Group III
Lintlha tsa Lintho tse Kotsi 72956-09-3(Boitsebiso ba Lintho tse Kotsi)
Chefo ea LD50 molomong oa ntja:> 1gm/kg

72956-09-3 -Kopo:

Carvedilol (CAS: 72956-09-03) ke vasodilating beta-blocker e sebetsang ho phekola khatello ea mali le angina pectoris.Ntle le ho fokotsa khatello ea mali, carvedilol e fokotsa ho hanyetsa ha methapo ea mali ntle le "reflex tachycardia" hangata e hlahang ka vasodilator.Ho tlalehoa hore e mamelloa hantle ka litlamorao tsa renal sparing.

Carvedilol e qalile ho hlahisoa Belgium ka 1985. Sehlahisoa sena se ka thibela li-receptor tsa alpha le beta, ha ho na ts'ebetso e ka hare, ka mekhoa e phahameng ea feshene e nang le khanyetso ea khalsiamo.E na le phello e matla ea ho thibela li-receptor tsa beta, tse ka atolosang methapo ea mali, ea fokotsa ho hanyetsa le ho fokotsa khatello ea mali, 'me e na le phello e fokolang ho phallo ea pelo le lebelo la pelo.Clinical e ka sebelisoa bakeng sa khatello ea mali ea mantlha le angina pectoris.

72956-09-3 - USP 35 Standard:

TLHALOSO

Carvedilol e na le NLT 98.0% le NMT 102.0% ea C24H26N2O4, e baloang ka mokhoa o omisitsoeng.

TS'ELISO TS'OANE

• A. Infrared Absorption <197K>

• B. Nako ea ho boloka tlhōrō e kholo ea tharollo ea Sample e lumellana le ea tharollo ea Maemo, joalo ka ha e fumanoe ho Assay.

TLHOKOMELO

• Tsamaiso

Buffer: 2.72 g/L ea monobasic potassium phosphate.Fetola ka asiti ea phosphoric e hlapollang ho pH ea 2.0.

Mohato oa mobile: Acetonitrile and Buffer (31:69)

Tharollo ea ho tšoaneleha ha tsamaiso: 0.05 mg/mL e 'ngoe le e 'ngoe ea USP Carvedilol RS le USP Carvedilol Related Compound A RS in Mobile phase

Tharollo e tloaelehileng: 0.04 mg / mL ea USP Carvedilol RS karolong ea Mobile

Tharollo ea mohlala: 0.04 mg / mL ea Carvedilol karolong ea Mobile

Sistimi ea chromatographic

(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)

Mokhoa: LC

Sesebelisoa: UV 240 nm

Kholomo: 4.6-mm × 15-cm;5-µm e paka L7

Mocheso oa kholomo: 55℃

Sekhahla sa phallo: 1 mL / min

Nako ea ho matha: 60 min

Boholo ba ente: 10 µL

Ho nepahala ha sistimi

Mohlala: Tharollo ea ho lekana ha sistimi

Litlhoko tsa ho tšoaneleha

Qeto: NLT 4.0 pakeng tsa carvedilol le carvedilol e amanang le motsoako A

Ntlha ea bohlokoa: NMT 1.5 bakeng sa tlhoro ea carvedilol

Phapang e amanang le maemo: NMT 2%

Tlhahlobo

Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala

Bala peresente ea carvedilol (C24H26N2O4) karolong ea sampole e nkiloeng:

Sephetho = (rU/rS) × (CS/CU) × 100

rU=	karabelo e phahameng ea carvedilol ho tsoa ho Sample solution
rS=	tlhōrō ea karabo ea carvedilol ho tsoa ho Standard solution
CS=	khatello ea carvedilol ka tharollo e tloaelehileng (mg/mL)
CU=	khatello ea kelello ea Carvedilol ka Sample solution (mg/mL)

Mekhoa ea ho amohela: 98.0% -102.0% motheong o omisitsoeng

LITŠILA

• Masalla a ho Tumisa <281>: NMT 0.1% ho tloha ho 1 g

• Heavy Metals, Mokhoa oa II <231>: NMT 10 ppm

• Litšila tsa 'mele, Mokhoa oa 1: [Tlhokomeliso-Motheong oa litšila tse teng, etsa litšila tsa Organic, Mokhoa oa 1 kapa Litšila tsa 'mele, Mokhoa oa 2. Litšila tsa 'mele, Mokhoa oa 2 o khothaletsoa ha motsoako oa carvedilol o amanang le F ke litšila tse ka bang teng.]

Buffer le Mobile phase: Lokisetsa joalokaha ho laetsoe ho Assay.

Tharollo ea ho tšoaneleha ha tsamaiso: 0.05 mg / mL e 'ngoe le e' ngoe ea USP Carvedilol RS le USP Carvedilol Related Compound C RS in Mobile phase

Tharollo e tloaelehileng: 1 µg/mL e 'ngoe le e 'ngoe ea USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, le USP Carvedilol Related Compound E RS, le 0.2 µg/mL ea USP Carvedil Related Compound C RS in Mobile phase

Tharollo ea mohlala: 1 mg / mL ea Carvedilol karolong ea Mobile

Sistimi ea chromatographic

(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)

Mokhoa: LC

Detector: Dual wavelength, UV 220 le 240 nm.Sebelisa 220 nm bakeng sa ho lekanya motsoako oa carvedilol E, 'me u sebelise 240 nm bakeng sa carvedilol le metsoako eohle e amanang le eona.

Kholomo: 4.6-mm × 15-cm;5-µm e paka L7

Mocheso oa kholomo: 55℃

Sekhahla sa phallo: 1 mL / min

Boholo ba ente: 20 µL

Ho nepahala ha sistimi

Mohlala: Tharollo ea ho lekana ha sistimi

Litlhoko tsa ho tšoaneleha

Qeto: NLT 17 pakeng tsa carvedilol le carvedilol e amanang le motsoako oa C

Tlhahlobo

Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala

Bala liperesente tsa motsoako o amanang le carvedilol A, motsoako oa B o amanang le carvedilol, motsoako o amanang le carvedilol C, motsoako o amanang le carvedilol D, motsoako oa carvedilol o amanang le E, le litšila leha e le life tse ling karolong ea Carvedilol e nkiloeng:

Sephetho = (rU/rS) × (CS/CU) × 100

rU	=	karabelo ea tlhoro ea motsoako o amanang le ona kapa litšila life kapa life tse tsoang ho Sample solution
rS	=	tlhōrō ea karabelo ea motsoako o tsamaellanang ho tsoa tharollong ea Maemo.Ho bala peresente ea litšila tse ling tsa motho ka mong sebelisa karabelo e phahameng ea carvedilol.
CS	=	mahloriso a motsoako o amanang le ona ka har'a tharollo e tloaelehileng (mg/mL).Ho bala peresente ea litšila tse ling tsa CS, sebelisa khatello ea USP Carvedilol RS.
CU	=	khatello ea kelello ea Carvedilol ka Sample solution (mg/mL)

Mokhoa oa ho amohela: Sheba Lethathamo la 1.

Lethathamo la 1

Lebitso	Nako ea ho Boloka Nako	Melao ea Kamohelo, NMT (%)
Motsoako o amanang le Carvedilol Ea	0.35	0.1
Motsoako o amanang le Carvedilol Ab	0.52	0.1
Carvedilol bisalkylpyrocatechol derivative (haeba e le teng)c	0.70	0.15
"Carvedilol"	1.0	-
Motsoako o amanang le Carvedilol Cd	3.6	0.02
Motsoako o amanang le Carvedilol De	5.0	0.1
Motsoako o amanang le Carvedilol Bf	8.5	0.1
Tšilafalo efe kapa efe e 'ngoe ea motho ka mong	-	0.10
Litšila kaofela	-	0.5g
2-(2-Methoxyphenoxy)ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Hlompha litšila leha e le life tse ka tlaase ho 0.01%.

• Litšila tsa 'mele, Mokhoa oa 2

Tharollo A: Acetonitrile le trifluoroacetic acid (100:0.1)

Tharollo B: Trifluoroacetic acid le metsi (0.1:100)

Diluent: Acetonitrile, trifluoroacetic acid, le metsi (22:0.1:78)

Mohato oa Mobile: Sheba Tafole 2

Lethathamo la 2

Nako (mots)	Tharollo A (%)	Tharollo B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Tharollo ea ho tšoaneleha ha tsamaiso: 1.0 mg/mL ea USP Carvedilol System Suitability Mixture RS in Diluent

Tharollo ea mohlala: 1 mg/mL ea Carvedilol ka Diluent

Sistimi ea chromatographic

(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)

Mokhoa: LC

Sesebelisoa: UV 240 nm

Kholomo: 4.6-mm x 15-cm;5-µm e paka L68

Mocheso oa kholomo: 30 ℃

Sekhahla sa phallo: 1.4 mL / min

Boholo ba ente: 20 µL

Ho nepahala ha sistimi

Mohlala: Tharollo ea ho lekana ha sistimi

Litlhoko tsa ho tšoaneleha

Qeto: NLT 1.8 pakeng tsa carvedilol le carvedilol e amanang le motsoako oa F

Tlhahlobo

Mohlala: Tharollo ea mohlala

Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Carvedilol e nkiloeng:

Sephetho = (rU/rT) × 100

rU	=	karabelo ea tlhoro bakeng sa ho se hloeke ka 'ngoe ho Sample tharollo
rT	=	kakaretso ea likarabo tsohle tsa tlhoro ho Sample tharollo

Mokhoa oa ho amohela: Sheba Lethathamo la 3.

Lethathamo la 3

Lebitso	Leloko Ho boloka Nako	Kamohelo Litekanyetso, NMT (%)
Motsoako o amanang le Carvedilol Aa	0.7	0.1
"Carvedilol"	1.0	-
Motsoako o amanang le Carvedilol Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Motsoako o amanang le Carvedilol Ce	1.8	0.02
Motsoako o amanang le Carvedilol Bf	2.1	0.1
Biscarbazoleg	3	0.1
Tšilafalo efe kapa efe e 'ngoe ea motho ka mong	-	0.1
Litšila kaofela	-	0.5
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1-(2-(2-Methoxyphenoxy)ethylamino) -3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol. c Ho se hloeke hona ho baloa ho sebelisoa mokhoa o tlas'a Litšila tsa Organic, Mokhoa oa 3: Carvedilol Related Compound F. d 1-(H-Carbazol-4-yloxy) -3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino] -2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy) -2-propanol.

• Litšila tsa Organic, Mokhoa oa 3: Carvedilol Related Compound F (haeba e le teng)

Tharollo A: Trifluoroacetic acid le metsi (0.5:100)

Tharollo B: Methanol le trifluoroacetic acid (100:0.5)

Diluent: Metsi le acetonitrile (1:1)

Mohato oa Mobile: Tharollo A le Tharollo B (65:35)

Tharollo ea ho tšoaneleha ha tsamaiso: 1.5 mg/mL ea USP Carvedilol System Suitability Mixture RS in Diluent

Tharollo ea mohlala: 1.5 mg/mL ea Carvedilol ka Diluent e lokiselitsoe ka tsela e latelang.Sebelisa hoo e ka bang 1.9 di ml ea Diluent ka mg ea Carvedilol, 'me sonicate ka bokhutšoanyane ho bebofatsa qhala.

Sistimi ea chromatographic

(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)

Mokhoa: LC

Sesebelisoa: UV 226 nm

Kholomo: 4.6-mm × 30-mm;3-µm e paka L7

Mocheso oa kholomo: 40 ℃

Sekhahla sa phallo: 2 mL / min

Boholo ba ente: 10 µL

Ho nepahala ha sistimi

Mohlala: Tharollo ea ho lekana ha sistimi

Litlhoko tsa ho tšoaneleha

Qeto: NLT 2.0 pakeng tsa carvedilol le carvedilol e amanang le motsoako oa F

Tlhahlobo

Mohlala: Tharollo ea mohlala

Bala peresente ea motsoako o amanang le carvedilol F karolong ea sampole e nkiloeng:

Sephetho = (rU/rT) × (1/F) × 100

rU	=	tlhōrō ea karabo ea carvedilol e amanang le motsoako oa F ho tloha ho Sample solution
rT	=	kakaretso ea likarabo tse phahameng tsa carvedilol le carvedilol e amanang le motsoako oa F ho tsoa ho Sample solution
F	=	ntlha e amanang le karabo, 1.1

Maemo a kamohelo: NMT 0.1%

LITEKO TSEKO

• Tahlehelo ha o Omisa <731>: Omisa sampole ka 105℃ bakeng sa 3 h: e lahleheloa ke NMT 0.5% ea boima ba eona.

KEKELETSO LIHLOKO

• Sephutheloana le ho Boloka: Boloka ka har’a linkho tse thata, ’me u li boloke mochesong o laolehileng oa kamore.

• Ho Ngola: Haeba ho sebelisoa teko ea Organic Impurities ka HPLC ntle le Mokhoa oa 1, joale ho ngolisoa ho bolela teko eo sengoloa se lumellanang le eona.

• USP Reference Standards <11>

USP Carvedilol RS

USP Carvedilol Related Compound A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74

USP Carvedilol Related Compound B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Related Compound C RS
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60

USP Carvedilol Related Compound D RS
4-(Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27

USP Carvedilol Related Compound E RS
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21

USP Carvedilol System Suitability Mixture RS
Motsoako oa hoo e ka bang 0.1% carvedilol e amanang le motsoako F (1-(2-(2-Methoxyphenoxy)ethylamino) -3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) ka matrix a ntho ea lithethefatsi ea carvedilol.