Risperidone CAS 106266-06-2 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Risperidone (CAS: 106266-06-2) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Risperidone,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Risperidone |
| Litlhaloso tse tšoanang | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-one;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 106266-06-2 |
| Foromo ea limolek'hule | Setšoantšo sa C23H27FN4O2 |
| Boima ba Molek'hule | 410.49 g/mol |
| Melting Point | 170.0 ho isa ho 174.0 ℃ |
| Botenya | 1.38±0.10 g/cm3 |
| Sehlopha sa Likotsi | 6.1;Chefo |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Litlhaloso | Liphetho |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu | E lumellana |
| Boitsebiso A | Ho kenngoa ha infrared | E lumellana |
| Boitsebiso B | Nako ea ho Boloka: E Tsamaellana le Ntho ea Tšupiso | E lumellana |
| Tahlehelo ka ho Omisa | <0.50% | 0.12% |
| Masalla a ho Ignition | <0.10% | 0.07% |
| Litšepe tse boima | <0.001% | <0.001% |
| Metsoako e Amanang | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Tšilafalo efe kapa efe e sa Tsejoeng | <0.10% | <0.10% |
| Litšila ka Kakaretso | <0.30% | <0.30% |
| Tlhahlobo | 98.0 ~ 102.0% (E baloa ka Motheo o Omisitsoeng) | 100.52% |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le USP 35 Standard | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl] -6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one [106266-06-2].
»Risperidone ha e na ka tlaase ho karolo ea 98.0 lekholong le e seng ho feta 102.0 lekholong ea C23H27FN4O2, e baloang motheong o omisitsoeng.
Ho paka le ho boloka- Boloka ka lijaneng tse koetsoeng hantle.Boloka mocheso oa kamore.
USP Reference standards <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one 410.48 CAS-106266-06-2
USP Risperidone System Suitability Mixture RS
E na le risperidone le hoo e ka bang 0.2% ea e 'ngoe le e 'ngoe ea tse latelang:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-one.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
[Hlokomela-Motsoako ona o na le risperidone, Z-oxime, 9-hydroxyrisperidone, le 6-methylrisperidone.]
Boitsebiso-
A: Infrared Absorption <197K>.
B: Nako ea ho boloka tlhoro e kholo ea chromatogram ea boitokisetso ba Assay e lumellana le e ho chromatogram ea Tokisetso e Tloaelehileng, joalo ka ha e fumanoe ho Assay.
Tahlehelo ka ho omisa <731> - E omisa ka vacuum ka 80 bakeng sa lihora tse 4: e lahleheloa ke ho feta 0.5% ea boima ba eona.
Masala a ho khantšang <281>: eseng ho feta 0.1%, ho sebelisoa mohlala oa teko ea 2.0-g.
Litšepe tse boima, Mokhoa oa II <231>: 0,001%.
Likopano tse amanang-
Tharollo ea Buffer, Tharollo ea A, Tharollo ea B, Mohato oa Mobile, Diluent, Tharollo ea ho tšoaneleha ha Sisteme, le Chromatographic system-Lokisetsa joalokaha ho laetsoe ho Assay.
Tharollo e tloaelehileng-Sebelisa Boitokisetso ba Maemo, bo lokisitsoeng joalo ka ha ho laetsoe ho Assay.
Tharollo ea teko-Sebelisa ho lokisetsa Assay.
Mokhoa-Enta meqolo e lekanang (hoo e ka bang 10 µL) ea Tharollo e Tloaelehileng le Tharollo ea Teko ka har'a chromatograph, 'me u tlalehe chromatogram.Lemoha litšila u sebelisa nako ea ho boloka e lekanyelitsoeng e fanoeng ho Lethathamo la 1, 'me u lekanye likarabelo tse phahameng.Bala peresente ea motsoako o mong le o mong o amanang le risperidone karolong ea Risperidone e nkiloeng ka foromo:
100(CS /CU)(rU / rS)(1/F)
moo CS le CU li leng teng, ka mg ka mL, ea risperidone ka tharollo ea Standard le Tharollo ea Tlhahlobo ka ho latellana;rU ke sebaka se phahameng sa ho se hloeke ka 'ngoe se fumanoang ho tsoa Tharollong ea Tlhahlobo;rS ke sebaka se phahameng sa risperidone se fumanoang ho tsoa ho Standard solution;le F ke lebaka le lekanyelitsoeng la karabelo bakeng sa ho se hloeke ka 'ngoe ho amanang le risperidone.Ntle le ho se fetele meeli ho Lethathamo la 1, ha ho na ho feta 0.10% ea litšila leha e le life tse sa tsejoeng (sebelisa boleng ba F ea 1.0) 'me ha ho 0.30% ea litšila tsohle tse fumanoang.Hlokomoloha litlhōrō tsa litšila tse ka tlaase ho 0.05%.
Lethathamo la 1
Related Compound Relative Retention Time (RRT) Relative Response Factor (F) Limit (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-one
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-one
Tlhahlobo-
Tharollo ea Buffer- Qhala 15.4 g ea ammonium acetate ka litara e le 'ngoe ea metsi.Fetola ka 10% acetic acid ho pH ea 6.5, 'me u kopanye.
Tharollo A-Mix 100 ml ea tharollo ea Buffer le 150 mL ea methanol ka har'a 1000-mL volumetric flask, 'me e hlapolle ka metsi ho isa bophahamong.
Tharollo B- Kopanya 100 ml ea tharollo ea Buffer le 850 ml ea methanol ka har'a 1000-mL volumetric flask, 'me u hlapolle ka metsi ho isa bophahamong.
Mobile phase-Sebelisa metsoako e feto-fetohang ea Tharollo A le Tharollo B joalokaha e laetsoe bakeng sa tsamaiso ea Chromatographic.Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Diluent - Kopanya 100 ml ea tharollo ea Buffer le 900 ml ea metsi le 1000 ml ea methanol.
Tharollo ea ho tšoaneleha ha Sisteme-Lokisetsa tharollo ea 1 mg ka mL ea USP Risperidone System Suitability Mixture RS in Diluent.
Tlhophiso e tloaelehileng-Hlakola tekanyo e lekantsoeng e nepahetseng ea USP Risperidone RS ho Diluent, 'me u hlapolle ka bongata, le ka mohato ka mohato ha ho hlokahala, ka Diluent ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 1.0 mg ka mL.
Ho lokisetsa tlhahlobo-Hlakola tekanyo e lekantsoeng e nepahetseng ea Risperidone ho Diluent, 'me u hlapolle ka bongata, le ha ho hlokahala, ka Diluent ho fumana tharollo e nang le motsoako o ka bang 1.0 mg ka mL.
Chromatographic system (sheba Chromatography <621>)- Mokelikeli oa chromatograph o na le detector ea 275-nm le kholomo ea 4.6-mm × 10-cm e nang le 3-µm packing L1.Sekhahla sa phallo ke hoo e ka bang 1.5 mL ka motsotso.Mocheso oa kholomo o bolokiloe ho 35. Chromatograph e hlophisitsoeng ka tsela e latelang.
Nako (metsotso) Tharollo A (%) Tharollo B (%) Elution
0–1 70 30 ea boikemelo
1–20 70®5 30®95 lekhalo la mola
20–25 5 95 ea boikemelo
25–27 5®70 95®30 lekhalo la mola
27–35 70 30 teka-tekano hapeKena tharollo ea ho tshwaneleha ha Sisteme.Ngola likarabo tsa tlhōrō joalokaha li laetsoe bakeng sa Tsamaiso, 'me u khetholle litlhōrō ka lebaka la Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, le risperidone ho sebelisa linako tse lekanyelitsoeng tsa ho boloka (RRT) ho tloha Lethathamong la 1;qeto, R, pakeng tsa Z-oxime le 9-hydroxyrisperidone ha e ka tlase ho 2.8;ntlha ea mohatla bakeng sa risperidone ha e fete 1.5;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang ha e fete 2.0% bakeng sa tlhoro ea risperidone.
Ts'ebetso- Kenya li-volumes tse lekanang ka karohano (tse ka bang 10 µL) tsa tokisetso e tloaelehileng le boitokisetso ba Assay ka har'a chromatograph, 'me u lekanye likarabo tsa tlhoro ea risperidone.Bala palo, ka liphesente tsa C23H27FN4O2, karolong ea Risperidone e nkiloeng ka foromo:
100(CS /CU)(rU / rS)
moo CS le CU li leng teng, ka mg ka mL, ea risperidone ka ho lokisetsa Standard le ho lokisetsa Assay, ka ho latellana;'me rU le rS ke likarabelo tse phahameng tse fumanoeng ho tsoa ho Tokisetso ea Assay le Tokiso ea Maemo, ka ho latellana.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Likhoutu tsa Kotsi R25 - E chefo ha e koetsoe
R23/24/25 - Chefo ka ho hema, ka ho kopana le letlalo le haeba e koetsoe.
R11 - E tuka Haholo
Tlhaloso ea Tšireletseho S28 - Ka mor'a ho kopana le letlalo, hlatsoa hang-hang ka sesepa e ngata ea sesepa.
S36 - Apara liaparo tse loketseng tsa tšireletso.
S45 - Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ho ngaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S36/37 - Apara liaparo tsa tšireletso tse loketseng le liatlana.
S16 - Qoba hole le mehloli ea mollo.
Li-ID tsa UN 3249
WGK Jeremane 3
RTECS UV1164800
HS Code 2934999099
Sehlopha sa Likotsi 6.1(a)
Sehlopha sa ho paka II
Risperidone (CAS: 106266-06-2) e na le phello ea antagonism ho li-receptor tsa 5HT2 le li-receptor tsa D2.Risperidone e sebelisoa bakeng sa schizophrenia e matla le e sa foleng.Lithethefatsi tsa antipsychotic.Risperidone e sebelisoa bakeng sa phekolo ea schizophrenia e hlobaetsang le e sa foleng le matšoao a mang a fapaneng a psychotic a hlakileng (joalo ka lipono, likhopolo, bothata ba ho nahana, lehloeo, lipelaelo) le matšoao a bohlokoa a mabe (joalo ka ho se arabele, ho hloka thahasello maikutlong le ho hloka thahasello sechabeng. mantsoe).Hape e ka fokotsa matšoao a amang a amanang le schizophrenia (joalo ka: khatello ea maikutlo, molato, matšoenyeho).Bakeng sa bakuli bao Risperidone e sebetsang ho bona bakeng sa kalafo e matla, nakong ea tlhokomelo ea kalafo, Risperidone e ka tsoela pele ho bapala katleho ea eona ea bongaka.Ka hona, risperidone e na le phello ea phekolo matšoao a mabeli a matle le a mabe a schizophrenia 'me e hlahisa litla-morao tse fokolang haholo-holo matšoao a extrapyramidal ha a bapisoa le li-antipsychotics tse sebelisoang hangata tse hloekileng tsa D2.E boetse e na le monyetla oa ho laola ho tlohela joala le bokhoba ba cocaine.
