4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Purity ≥98.0% (HPLC)
Shanghai Ruifu Chemical ke moetsi ea ka sehloohong oa 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Prucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid |
| Litlhaloso tse tšoanang | 4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Tšilafalo ea Prucalopride A;Prucalopride Succinate Ho se hloeke-2 |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 123654-26-2 |
| Foromo ea limolek'hule | C9H8ClNO3 |
| Boima ba Molek'hule | 213.62 g/mol |
| Melting Point | 242 ℃(Dec.) |
| Ntlha e belang | 406.5±45.0℃ |
| Botenya | 1.566 |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Sehlopha | Bohareng ba Prucalopride Succinate (CAS: 179474-85-2) |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | E Tiileng Hantle-Bosoeu ho isa ho Bofubelu bo Khanyang | Leseli-Bokhubelu bo Tiileng |
| Metsi ka Karl Fischer | ≤1.00% | 0.35% |
| Masalla a ho Ignition | <0.20% | 0.08% |
| Litšepe tse boima (Pb) | ≤20ppm | <10ppm |
| Tšilafalo e le Mong | ≤1.00% | E lumellana |
| Litšila ka Kakaretso | ≤2.00% | E lumellana |
| Mokhoa oa Bohloeki / Analysis | ≥98.0% (HPLC) | 99.6% |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| 1 H NMR Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Sehlahisoa sena ke 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, litaba tsa C12H12ClNO4 ha li na ho ba ka tlase ho 98.0%, tse baloang ka mokhoa oa anhydrous.
[Properties] Sehlahisoa sena se bosoeu bo bosoeu ho isa ho bokhubelu bo bobebe.
[Sheba]
Nka tekanyo e loketseng ea sehlahisoa sena (hoo e ka bang 0.5g) ea metsi, eketsa solvent (methanol: N, N-dimethylformamide = 50:50), 'me u e qhaqha ho ea ka mokhoa oa ho etsa qeto ea metsi (Sehlomathiso Ⅷ M, mokhoa oa pele oa A).Sebelisa marotholi a tlhahlobo ea Fisher ho tseba ho fihlela tharollo e fetoha ho tloha ho mosehla o khanyang ho ea ho bofubelu bo bofubelu bo bontšang qetello, 'me u etse tlhahlobo e' ngoe e se nang letho.Bala ho ea ka mokhoa o latelang: metsi ha aa lokela ho feta 1.00%.
Mongobo (%) = (AB) F/W×100%
Moo, A ke bophahamo ba mokelikeli oa Fisher o sebelisoang ke sehlahisoa sa teko (ml);
B ke bophahamo ba mokelikeli oa tlhahlobo oa Fisher o sebelisoang ke sebaka se se nang letho, ml;
F ke boima ba tharollo ea tlhahlobo ea Fisher e lekanang le metsi ka 1ml, mg;
W ke boima ba sehlahisoa sa teko, mg
Ntho e amanang le yona
Ho ea ka mokhoa o tlas'a "Tekanyo ea litaba", haeba ho na le litlhoro tsa ho se hloeke ka har'a chromatogram ea tharollo ea tlhahlobo, sebaka se phahameng sa litšila se le seng ha se na ho feta makhetlo a 10 (1.0%) ea sebaka se seholo sa taolo. tharollo, 'me kakaretso ea sebaka sa tlhōrō ea litšila tsohle ha ea lokela ho ba makhetlo a 20 (2.0%) a sebaka se seholo sa tlhōrō ea tharollo ea taolo.
[Tlhahiso ea Litaba] Ho latela ts'ebetso e phahameng ea mokelikeli chromatography (Sehlomathiso VI D).
Octadecylsilane bonded silica gel e ne e sebelisoa e le setlatsi bakeng sa maemo a chromatographic le liteko tsa ho lekana ha sistimi.Phosphate buffer solution (1.36g potassium dihydrogen phosphate, dissolved ultrasonic in 1L water, phosphoric acid e fetotsoeng ho PH 3.0) e ne e sebelisoa e le mobile phase A. Acetonitrile ke mobile phase B, 'me gradient elution e etsoa ho latela tafole e latelang:
Nako (min) Mohato oa mobile oa A mobile phase B
08020
15 80 20
30 50 50
45 50 50
Nako ea ho lemoha e ne e le 254 nm.Sekhahla sa phallo e ne e le 1.0 ml / min.Palo ea lipoleiti tsa theoretical ha li ka tlase ho 2000 ho ea ka tlhōrō ea 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Tlhōrō ea furanoformic acid ha e ka tlaase ho 2000.
Mokhoa oa ho khetha:
Nka 10mg ea sehlahisoa sa teko, se lekanya ka nepo, se kenye ka botlolong ea A 10ml, se qhibilihe ka ultrasonic le mobile phase A-mobile phase B (70:30) e le solvent, e hlapolle ho isa tekanyong, sisinya hantle, 'me u lokise tharollo e nang le mahloriso a 1mg/ml.20 l ea ho nepahala e ile ea kenngoa ka har'a chromatograph ea metsi, 'me chromatogram e ngotsoe.Tlhoeko e kholo ea tlhoro e ne e se ka tlase ho 98.0% ho latela mokhoa oa ho tloaeleha ha sebaka se phahameng
Kholomo: Dionex Acclaim C18, 4.6 * 250mm, 5um
Mocheso oa kholomo: 40 ℃
Sekhahla sa phallo: 1.0ml/min
Nako ea ho lemoha: 254nm
Saese ea mohlala: 10μL
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), e ka sebelisoa e le bohareng bakeng sa motsoako oa Prucalopride Succinate (CAS: 179474-85-2), 5-HT4 receptor agonist e khethiloeng e sebelisoang ka katleho bakeng sa ho patoa ho sa foleng.Prucalopride Succinate, e leng dihydrobenzofurancarboxamide ea pele-pele, ke serotonin e khethiloeng (5- HT4) receptor agonist.Setlhare sena, se rekisoang ka lebitso la Resolor®, se na le tšebetso ea enterokinetic mme se entsoe ke feme ea meriana e thehiloeng Belgian ea Movetis.Prucalopride e fetola mekhoa ea motility ea colonic ka serotonin 5-HT4 receptor stimulation, e leng se etsang hore ho be le matla a bohareng a propulsive for defecation.
