Vardenafil ea Mahareng CAS 224789-21-3 Bohloeki > 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one. (CAS: 224789-21-3) e nang le boleng bo phahameng, bohareng ba Vardenafil.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one |
| Litlhaloso tse tšoanang | Vardenafil Dessulfonyl Ho se hloeke;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-one;Vardenafil Propyl Imidazotriazinone Ho se hloeke;Motsoako o amanang le Vardenafil 1 |
| Boemo ba Setoko | Ka Setokong, Bokhoni ba Tlhahiso Lithane tse 2 ka Khoeli |
| Nomoro ea CAS | 224789-21-3 |
| Foromo ea limolek'hule | Setšoantšo sa C17H20N4O2 |
| Boima ba Molek'hule | 312.37 g/mol |
| Melting Point | 142.0 ~ 148.0 ℃ |
| Botenya | 1.26±0.10 g/cm3 |
| Polokelo ea Nako e telele | Sebaka se pholileng le se omileng (2~8℃) |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Litlhaloso | Liphetho |
| Ponahalo | Phofo e Bosoeu ho isa ho Bosehla bo Bosehla | Phofo e Ntle-Tšweu |
| Melting Point | 142.0 ~ 148.0 ℃ | 146.0 ~ 147.0 ℃ |
| Tahlehelo ka ho Omisa | <1.00% (102℃, 3h) | 0.23% |
| Litšepe tse boima (Pb) | ≤20ppm | <20ppm |
| Mokhoa oa Bohloeki / Analysis | >99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
| Kopo | Bohareng ba Vardenafil / Vardenafil Hydrochloride | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa khanya ea letsatsi le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
1. Ponahalo: Beha sampole pampiring e tšoeu 'me u shebe ponahalo, e tšoeu ho isa ho phofo e mosehla.
2. Tlhahlobo:
2.1 Boikemisetso ba Ntlha e qhibidihang ho ya ka molao (Chinese Pharmacopoeia 2010 Edition II Appendix ⅥC) Sebaka se qhibidihang ke 142.0~148.0℃.
2.2 Tahlehelo Nakong ea ho Omisa: Boikemisetso ho ea ka molao (Sehlomathiso ⅧL, Karolo ea II, Khatiso ea 2010 ea Chinese Pharmacopoeia).Ho nepahala ha boima ba sehlahisoa sena, se omme ho 102 ℃ bakeng sa lihora tse 3, tahlehelo ea boima ba 'mele ha ea lokela ho feta 1.00%.
2.3 Metals e boima: Boikemisetso ho ea ka molao (People's Republic of China Pharmacopoeia Khatiso ea 2010, Karolo ea II Sehlomathiso ⅧH) Boikemisetso ka mokhoa oa bobeli.
Ho nepahala ho boima ba 1.0g ea sehlahisoa sa teko, butle-butle ho chesa ho fihlela carbonized ka ho feletseng, e pholile, eketsa 0.5-1.0ml sulfuric acid, e etsa hore e be mongobo, mocheso ka mocheso o tlase ho fihlela sulfuric acid e felile, eketsa 0.5ml nitric acid, mouoane o omme, ho fihlela mouoane oa nitrogen oxide o felile, o pholile, o chesa ho 500-600 ℃ ho carbonized ka ho feletseng, o pholile, eketsa 2ml hydrochloric acid, Ka mor'a ho omisa ka ho hlapa metsi, eketsa metsi a 15ml, u lahlele tharollo ea ammonia ho fihlela e fetoha lehlakore ho pontšo ea phenolphthalein. tharollo, eketsa 2ml acetate buffer (ph3.5), 'me u qhale mocheso hanyenyane, u e ise ho Nachner colorimetric tube,' me u e hlapolle ka 25ml ka metsi.Nka reagent e 'ngoe bakeng sa ho lokisa tharollo ea teko,' me ue chese ka sejana sa porcelain, eketsa 2ml acetate buffer (PH3.5) le 15ml metsi ho mocheso o monyenyane Ka mor'a ho qhibiliha, tsamaisa tube ea Nath colorimetric, eketsa tekanyo e itseng ea tharollo e tloaelehileng ea lead, ebe o hlapolla ka metsi ho isa ho 25ml.Teko ea colorimetric e etsoa lipakeng tsa tharollo ea liteko le tharollo e tloaelehileng eo u ka e fumanang.Tekanyetso ea ho lokisa tharollo ho latela (People's Republic of China Pharmacopoeia 2010 edition II Sehlomathiso Ⅷ Heavy metal test method) mokhoa oa pele.Litšepe tse boima ha lia lokela ho feta likarolo tse 20 ho milione.
3. Bohloeki: Ho ea ka ts'ebetso e phahameng ea chromatography ea mokelikeli, e ikemiselitseng ho ea ka molao (Chinese Pharmacopoeia 2010 edition II Appendix VD).
Maemo a Chromatographic:
Kholomo: C18, 200mm×4.6mm, 5μm;
Mokhahlelo oa selefouno: Phosphate buffer (ka boima ba 2.72g potassium dihydrogen phosphate, eketsa metsi ho qhala le ho hlapolla ho 1000ml, lokisa pH=3.5) : acetonitrile: = 35:65;
Leqhubu la ho lemoha: 254nm;
Sekhahla sa phallo: 1.0ml/min.
Mokhoa oa ho etsa qeto: Nka hoo e ka bang 30mg ea sehlahisoa sena, u se lekanye ka nepo, u se hlapolle ka mohato oa selefouno ho etsa hore mahloriso a ka bang 0.3mg/ml, nka 20μl ho chromatograph ea metsi, rekota chromatogram.Ho latela mokhoa oa ho tloaeleha sebakeng, bohloeki ha bo ka tlase ho 99.0%.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) ke bohareng ba Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil ke PDE5 inhibitor e ncha e qalileng bakeng sa phekolo ea molomo ea ho se sebetse ha banna erectile 'me e na le sebopeho se seholo sa sebopeho le sildenafil (Viagra), eo e neng e le eona PDE5 inhibitor ea pele e hlahisitsoeng ka 1998 bakeng sa pontšo ena.
Vardenafil e ne e le moemeli oa bobeli ea lokelang ho rekisoa 'me o ne a e-na le molemo oa hore nako ea eona ea ho qala ha ea ka ea fokotseha ka ho noa meriana ka mpeng e feletseng .E na le matla a 30 ka makhetlo a mangata e le inhibitor ea PDE5 (e bolelang IC50, 3.9 nM) ho feta sildenafil le linako tse 10 tse matla ho feta tadalafil, ka khetho e kholo (> makhetlo a 1,000) bakeng sa PDE5 ea motho ho feta PDE2, PDE3, le PDE4 ea batho le khetho e itekanetseng (> makhetlo a 80) bakeng sa PDE1.The PDE inhibitory selectivity le in vitro le in vivo potency ea PDE5 inhibitor vardenafil e ncha.Vardenafil e ile ea thibela ka ho khetheha hydrolysis ea cGMP ka PDE5, e nang le IC50 ea 0.7 nM (sildenafil 6.6 nM).IC50 ea vardenafil bakeng sa PDE1 e ne e le 180 nM, bakeng sa PDE6 11 nM, le bakeng sa PDE2, PDE3 le PDE4 ho feta 1,000 nM.
