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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
Ruifu Chemical ke mofani ea ka sehloohong oa Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) e nang le boleng bo phahameng, bohareng ba Apixaban (CAS: 503612-47-3).Ruifu e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, palo e nyane le e ngata e fumanehang.Reka li-intermediate tsa Apixaban, E-mail: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Litlhaloso tse tšoanang | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Tšilafalo ea Apixaban 3 |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 27143-07-3 |
| Foromo ea limolek'hule | C11H13ClN2O3 |
| Boima ba Molek'hule | 256.69 g/mol |
| Melting Point | 94℃ |
| Botenya | 1.23 |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Sehlopha | Bohareng ba Apixaban (CAS: 503612-47-3) |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Bosehla bo Khanyang ho isa ho Phofo e Sehla | E lumellana |
| Tahlehelo ka ho Omisa | <0.50% | 0.23% |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| 1 H NMR Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Lethathamo la Litlhapi Tse Sebelisitsoeng Tlhahisong
| Che. | Lebitso | Nomoro ea CAS. | Foromo ea limolek'hule |
| 1 | Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Joala ba Ethyl | CAS: 64-17-5 | C2H5OH |
5.3.1 Ponahalo: E lokela ho ba phofo e mosehla ho isa ho e mosehla.Ka pono, beha bongata bo lekaneng ba sehlahisoa sa teko (ntle le boima) ka har'a sejana se hloekileng sa kristale se ka morao (joaloka pampiri e tšoeu) tlas'a khanya ea tlhaho.
5.3.2 Boitsebiso: 1H-NMR e na le sebopeho se tšoanang le se tloaelehileng.10 ~ 15mg ea sampole e ile ea lekoa ka har'a tube ea makenete ea nyutlelie, 'me 0.5mL ea deuterium DMSO e ile ea eketsoa ho qhala sampole ka botlalo, ebe e lekoa ka sesebelisoa sa nyutlelie sa makenete se fetang 400MHz.
5.3.3 Tahlehelo nakong ea ho omisa : Beha sampole ka 1.0g 'me u e omise bakeng sa 3h ka ontong e omisang ka 85℃.Ts'ebetso e khethehileng ea ho bala boima ba 'mele e tla etsoa ho ea ka litokisetso tsa SOP-AP-QC-002-01 bakeng sa Boikemisetso ba ho Omisa Boima ba Boima.
5.3.4.1 Maemo a Chromatographic:
Lisebelisoa tsa liteko: 1) acetonitrile bakeng sa chromatography 2) metsi a hloekisitsoeng 3) asiti ea phosphoric
Kholomo: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Mokhahlelo oa selefouno: A: Lekanya ka nepo 1.0ml phosphoric acid le 1000ml metsi, sefa ultrasonic degassing.
B: Acetonitrile.
Mokhoa oa gradient: tafole e latelang
Nako mokhahlelo oa A (%) Mohato oa mohala oa B (%)
3 90 10
10 25 75
20 0100
25 0 100
Sesebelisoa: 210nm
Mocheso oa kholomo: 35 ℃
Lebelo la ho phalla: 1.0ml / min
Saese ea mohlala: 5µl
5.3.4.2 Tokiso ea tharollo:
5.3.4.3 Mokelikeli: acetonitrile
5.3.4.4 Tharollo e se nang letho: mokelikeli o tla sebelisoa e le tharollo e se nang letho.
5.3.4.5 Tharollo ea sehlahisoa sa teko: Beha sehlahisoa sa teko ka boima ba 12.5mg ka har'a botlolo ea volumetric ea 25ml 'me u e qhale ka mokelikeli ho ea sekaleng.
5.3.4.6 Ts'ebetso ea ts'ebetso: Ka mor'a hore motheo oa sesebelisoa o tsitsitse, ente e le 'ngoe ho isa ho tse peli tsa tharollo e se nang letho e tsoetse pele, ebe tharollo ea sehlahisoa sa teko e hlahlojoa.Chromatogram ea bolokoa le ho hlahlobisisoa, tlhoro e se nang letho e tlosoa, 'me tlhoeko e kholo ea tlhoeko le liphetho tse sa hloekang tse le 'ngoe ho chromatogram ea sehlahisoa sa tlhahlobo li tlalehiloe ka mokhoa oa tloaelo oa sebaka.Ka mor'a tlhahlobo, chromatogram e ile ea hatisoa.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Ethyl Chloro [(4-Methoxyphenyl) hydrazono]acetate (CAS: 27143-07-3) e sebelisoa e le sebaka se ka hare ho motsoako oa Apixaban (CAS: 503612-47-3).Apixaban ke mofuta o mocha oa oral factor Xa inhibitor e kopantsoeng ke Bristol-Myers Squibb le Pfizer.Lebitso la khoebo ke Erroto.Ke mofuta o mocha oa anticoagulant ea molomo.Ka ho thibela ntho ea bohlokoa ea coagulation Xa, apixaban e ka thibela tlhahiso ea thrombin le thrombosis.Apixaban e entsoe ke Bristal-Myers squibb Company.E na le bioavailability e ntle le khetho e phahameng.E ne e thathamisitsoe Chaena ka 2013. Apixaban e sireletsehile, monyetla oa ho sebelisana le lithethefatsi o monyenyane, 'me ho na le litsela tse ngata tsa ho e felisa, tse lebeletsoeng ho sebelisoa ka lihlopha tse khethehileng tse nang le lefu la sebete kapa ts'ebetso ea liphio.
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