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Ibrutinib Intermediate CAS 330792-70-6 Bohloeki >98.0% (HPLC) Setšoantšo se Featured
  • Ibrutinib Intermediate CAS 330792-70-6 Bohloeki >98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Bohloeki >98.0% (HPLC)

Tlhaloso e Khutšoanyane:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Bohloeki: >98.0% (HPLC)

Ponahalo: Bosoeu bo Bosoeu ho ea ho Phofo e Bosehla bo Khanyang

Bohareng ba Ibrutinib (CAS: 936563-96-1) 

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Lithethefatsi tsa Ibrutinib:

Ibrutinib CAS 936563-96-1
3-Hydroxypiperidine CAS 6859-99-0
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S) -1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo[3,4-d]pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8
Ibrutinib Deacryloylpiperidine CAS 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Litlhaloso tse tšoanang Ibrutinib Intermediate N-3;3-Amino-5-(4-Phenoxyphenyl)pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5-(4-Phenoxyphenyl)pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Nomoro ea CAS 330792-70-6
Boemo ba Setoko Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule Setšoantšo sa C16H12N4O
Boima ba Molek'hule 276.29
Botenya 1.37±0.10 g/cm3
COA & MSDS E fumaneha
Tšimoloho Shanghai, China
Brand Ruifu Chemical

Litlhaloso:

Ntho Litlhaloso
Ponahalo Phofo e Bosoeu ho ea ho Bosehla bo Khanyang
Mokhoa oa Bohloeki / Analysis >98.0% (HPLC)
Tahlehelo ka ho Omisa <1.00%
Masalla a ho Ignition <0.50%
Litšila ka Kakaretso <2.00%
Heavy Metals (as Pb) <20ppm
1 H NMR Spectrum E tsamaellanang le Sebopeho
Tekanyetso ea Teko Maemo a Khoebo
Tšebeliso Bohareng ba Ibrutinib (CAS: 936563-96-1)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo.

Melemo:

1

LBH:

www.ruifuchem.com

330792-70-6 - Kopo:

5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) ke bohareng ba Ibrutinib (CAS: 936563-96-1).Ibrutinib e bonts'a phello e matla le e ke keng ea fetoloa ea inhibitory le khetho bakeng sa mosebetsi oa Btk oa enzymatic.Ka BCR tsela-activated DOHH2 cell line, Ibrutinib e thibela autophosphorylation ea Btk, phosphorylation ea Btk's physiological substrate PLCγ, le phosphorylation of more downstream kinase, ERK le IC50 ea 11 nM, 29 nM le 13 nM, ka ho latellana.Ibrutinib e bonts'a ts'ebetso e kholo e itšetlehileng ka tekanyo le nako e itšetlehileng ka nako ea cytotoxicity liseleng tse sa foleng tsa lymphocytic leukemia (CLL).Ho phaella moo, Ibrutinib e etsa hore lisele li shoe ho itšetlehile ka ts'ebetso ea caspase le ho hanyetsa bokhoni ba lisele tsa CLL ho ata ka mor'a pontšo ea TLR.

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