CAS 361442-04-8 Purity >99.0% (HPLC) API

Tlhaloso e Khutšoanyane:

Mantsoe a tšoanang: BMS-477118;Onglyza

CAS: 361442-04-8

Bohloeki: >99.0% (HPLC)

Ponahalo: Phofo e tšoeu

API, Boleng bo Phahameng, Tlhahiso ea Khoebo

E-Mail: alvin@ruifuchem.com

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Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Related Intermediates
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2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Lintho tsa Lik'hemik'hale:

Litlhaloso tse tšoanang	BMS-477118;Onglyza;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl] -2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Nomoro ea CAS	361442-04-8
Nomoro ea KAtse	RF-PI1991
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C18H25N3O2
Boima ba Molek'hule	315.41
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e Tshweu
Monko o monate	Sebopeho
boitsebiso	A: IR B: HPLC Nako ea ho Boloka
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)
Ho Hlakola ha Tharollo ea Metsi	Lintho tse Bonahalang, Tse se Nang Mebala, Ha ho na Litaba tse Emisitsoeng
Sieve Analysis	100% Feta 80 Mesh
Melting Point	202.0~212.0℃
Tahlehelo ka ho Omisa	<0.50%
Molora oa Sulfate	<0.20%
Phetoho e khethehileng	+174.0°~+186.0°
Tšilafalo e le Mong	<0.50%
Litšila ka Kakaretso	<1.00%
Litšepe tse boima	<10ppm
Arsenic (As)	<2.0ppm
Ketapele (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Metsoako e setseng	<100ppm
Sebolaea Likokoanyana se Seng	E mpe
Microbiology
Kakaretso ea Plate Count	<1000cfu/g
Yeast & Mold	<100cfu/g
E. Coli	E mpe
S. Aureus	E mpe
Salmonella	E mpe
Shelf Life	Likhoeli tse 24 ho tloha ka Letsatsi la Tlhahiso haeba li bolokiloe hantle
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API;Mofuta oa 2 oa lefu la tsoekere mellitus

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

(BMS-477118) (CAS: 361442-04-8) ke inhibitor e matla, e khethang, e fetohang, ea tlhōlisano le e sebetsang ka molomo dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM).BMS-477118 e na le peotential bakeng sa mofuta oa 2 lefu la tsoekere mellitus.BMS-477118ke sethethefatsi sa lefu la tsoekere la mofuta oa 2 se ka susumetsang manyeme hore a hlahise insulin e ngata ka mor'a lijo.E fihletsoe ke tšebelisano-'moho ea AstraZeneca le Bristol-Myers Squibb Company 'me ke ea DPP-IV inhibitor.BMS-477118e bapala karolo ka ho thibela ho senyeha ha GLP-l.GLP-I ke lihomone tsa tlhaho tse hlahisoang ka maleng ka mor'a ho ja.E ka laola secretion ea insulin le ho matlafatsa ts'ebeliso ea tsoekere liseleng tsa peripheral.Moriana o le mong oa BMS-477118 o ka ntlafatsa taolo ea tsoekere ea mali le meriana e kopaneng ea BMS-477118 e nang le Metformin, Sulfonylurea le Thiazolidinediones e ka ntlafatsa phello ea pholiso.E lebisa kotsing e tlase ea hypoglycemia mme litlamorao tsa eona tse mpe li tšoana le placebo, e bonts'a mamello e betere.Ka la 31 Phupu 2009, BMS-477118 matlapa (Onglyza), sethethefatsi se secha sa lefu la tsoekere la mofuta oa 2, se entsoeng ka kopanelo le ho nts'etsapele AstraZeneca le Bristol-Myers Squibb e amohetsoe ke US FDA.E ka nkoa hang ka letsatsi ho phekola lefu la tsoekere la mofuta oa 2 hammoho le ho laola Lijo le boikoetliso.