Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H) -one Purity ≥99.0% (HPLC)
Ruifu Chemical ke moetsi ea ka sehloohong oa 3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H)-one (CAS: 503615-03-0) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka li-intermediate tsa Apixaban,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one |
| Litlhaloso tse tšoanang | 3-(4-Morpholinyl) -1-(4-Nitrophenyl)-5,6-Dihydro-2(1H)-Pyridinone;5,6-Dihydro-3- (4-Morpholinyl) -1- (4-Nitrophenyl) -2 (1H) -Pyridinone;Apixaban Intermediate 3;Tšilafalo ea Apixaban 36;Tšilafalo ea Mokhoa oa Apixaban 1 |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 503615-03-0 |
| Foromo ea limolek'hule | C15H17N3O4 |
| Boima ba Molek'hule | 303.31 g/mol |
| Melting Point | 165.0 ~ 170.0℃ |
| Ntlha e belang | 506.5±50.0℃ |
| Botenya | 1.357g/mL |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Sehlopha | Bohareng ba Apixaban (CAS: 503612-47-3) |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo e Sehla | Phofo e Sehla |
| Melting Point | 165.0 ~ 170.0℃ | 167.0 ~ 170.0 ℃ |
| Tahlehelo ka ho Omisa | ≤0.50% | 0.3% |
| Tšilafalo ea Motho ka Mong (Max.) | ≤0.50% | 0.3% |
| Litšila ka Kakaretso | ≤1.00% | 0.6% |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC) | 99.4% |
| 1 H NMR Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| LC/MS | E tsamaellanang le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H)-e le 'ngoe (CAS: 503615-03-0) ke ea bohareng bakeng sa motsoako oa Apixaban (CAS: 503612-47-3) .
Apixaban ke mofuta o mocha oa oral Xa factor inhibitor e kopantsoeng ke Bristol-Myers Squibb le Pfizer.Lebitso la khoebo ke Eratol, e leng mofuta o mocha oa anticoagulant ea molomo.Ka ho thibela ntho ea bohlokoa ea coagulation Xa, Apixaban e ka thibela tlhahiso ea thrombin le thrombosis.
Ka April 26, 2007, Bristol-Myers Squibb o ile a ikopanya le Pfizer ho phatlalatsa tšebelisano-'moho ho nts'etsopele ea anticoagulant e ncha ea molomo Apixaban e nang le Bristol-Myers Squibb e le mokhoa o ntlafalitsoeng oa warfarin.Ho ea ka tumellano ea tšebelisano, Pfizer e tla lefa tefo ea pele ea US $ 0.25 bilione ho Bristol-Myers Squibb ho jara 60% ea kakaretso ea litšenyehelo tsa nts'etsopele ea anticoagulant Apixaban (e tla kengoa tšebetsong ho tloha ka Pherekhong 1, 2007), ha Bristol-Myers. Squibb e tla jara karolo e setseng ea 40%, kahoo e fumane tokelo ea ho kopanya le ho rekisa lithethefatsi.
Ka May 2011, Apixaban e bile eena oa pele oa ho amohela thibelo ea venous thrombosis ho bakuli ba baholo ba etsoang opereishene e khethehileng ea letheka kapa lengole linaheng tsa 27 EU, Iceland le Norway.
Ka la 20 November, 2012, Komisi ea Europe e ile ea amohela Ererto (Apixaban) bakeng sa thibelo ea lefu la stroke le systemic embolism ho bakuli ba baholo ba nang le non-valvular atrial fibrillation (NVAF) e nang le mabaka a le mong kapa a mangata a kotsi.Ka mor'a moo, Tsamaiso ea Lijo le Lithethefatsi ea Canada, Japane, le US FDA e amohetse Ererto (Apixaban) bakeng sa thibelo ea lefu la stroke le systemic embolism ho bakuli ba baholo ba nang le non-valvular atrial fibrillation (NVAF) e nang le kotsi e le 'ngoe kapa ho feta.
Ka April 12, 2013, lithethefatsi tse ncha tsa anticoagulant Eloto (ELIQUIS) (apixaban) tse kopantsoeng ke Bristol-Myers Squibb le Pfizer li phatlalalitsoe ka molao hore li thathamisitsoe Chaena.Ererto ke novel oral factor Xa inhibitor bakeng sa thibelo ea venous thromboembolism (VTE) ho bakuli ba baholo ba nkeloang sebaka sa letheka kapa lengole.Lethathamo la eona le fana ka khetho e ncha e bolokehileng le e sebetsang bakeng sa anticoagulation ea bongaka kamora ho buuoa ka masapo, mme e tlisa litaba tse monate ho bakuli ba Machaena ba nkeloang sebaka sa khetho ea letheka / lengole.Liphuputso tsa bongaka li netefalitse hore ha ho bapisoa le 40mg enoxaparin hanngoe ka letsatsi, makhetlo a 2 ka letsatsi tsamaiso ea molomo ea Eratol (Apixaban) 2.5mg e sebetsa haholo bakeng sa ho thibela venous thromboembolism ka mor'a ho buuoa ka letheka kapa lengole, 'me ha e eketse kotsi ea ho tsoa mali.
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