TMC207 CAS 843663-66-1 Bohloeki >99.5% (HPLC)
Litaba tse amanang le TMC207:
TMC207 CAS 843663-66-1
3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Lebitso la Lik'hemik'hale | TMC207 |
| Litlhaloso tse tšoanang | TMC-207, R207910;Sirturo;(αS,βR) -6-Bromo-α--[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-Bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanol |
| Nomoro ea CAS | 843663-66-1 |
| Nomoro ea KAtse | RF2336 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C32H31BrN2O2 |
| Boima ba Molek'hule | 555.516 |
| Melting Point | 104℃ |
| Botenya | 1.322±0.06 g/cm3 |
| E hloahloa | Hygroscopic.E Mamela Khanya, E Mamela Moea |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo e tšoeu kapa e sa bosoeu |
| Mokhoa oa Bohloeki / Analysis | >99.5% (HPLC) |
| Tahlehelo ka ho Omisa | <0.50% |
| Masalla a ho Ignition | <0.20% |
| Tšilafalo efe kapa efe ea Motho ka Mong | <0.10% |
| Isomer | <0.10% |
| Litšila ka Kakaretso | <0.50% |
| Heavy Metals (as Pb) | <20ppm |
| Arsenic (As) | <2.0ppm |
| Infrared Spectrum | E Ikamahanya le Sebopeho |
| Proton NMR Spectrum | E Ikamahanya le Sebopeho |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | API |
Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo
Mokhoa oa ho Reka?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?E romelloa haholo Amerika Leboea, India, Russia, Korea, Japane le Europe, joalo-joalo.
BolengTiisetso?Tiisetso ea boleng bo ka tšeptjoang, tsamaiso e tiileng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka leoatle.
Custom Synthesis?E ka fana ka litšebeletso tse tloaelehileng tsa synthesis.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
(CAS: 843663-66-1), (e tsejoang e le TMC207 le R207910), e rekisoang tlas'a lebitso la khoebo la Sirturo, ke novel diarylquinoline antimycobacterial drug e amang lefuba ka ho thibela mosebetsi oa M. lefuba ATP synthase proton pump.The ATP synthesis ea mycobacteria e na le liphello tsa antibacterial le bactericidal.E sebelisoa ho phekola lefuba la batho ba baholo le hanyetsanang le lithethefatsi (MDR-PTB).TMC207 e na le ts'ebetso e ts'oanang ea baktheria khahlano le mefuta ea lefuba ea M. lefuba le mefuta e hanyetsanang, hape e na le phello e ntle ea ho thibela likokoana-hloko ho libaktheria tse robetseng.Ka Tšitoe 2012, US FDA e ile ea amohela TMC207 e le karolo ea motsoako oa phekolo ea lefuba le hanyetsanang le lithethefatsi tse ngata (MDRTB).TMC207 ke setlhare sa pele se amohetsweng bakeng sa MDR-TB mme ke tumello ya pele ho tswa ho sehlopha se setjha sa diakgente tse thibelang lefuba dilemong tse 40 tse fetileng.Ka lebaka la tlhokeho e phahameng e sa laoleheng ea ho phekola MDR-TB, FDA e fane ka tumello e potlakileng ea TMC207 e ipapisitseng le liphetho tsa Mokhahlelo oa II, ho fa bakuli monyetla oa ho fumana moriana ha lithuto tsa tlatsetso tsa bongaka li ntse li etsoa.TMC207 ke diarylquinoline e ileng ya fumanwa ho tswa ho leano la ho hlahlobisisa disele kaofela ka Mycobacterium smegmatis e sebediswang e le moemedi wa M. lefuba.TMC207 ke enantiomer e le 'ngoe ea pina ea pele ea tlhahlobo.TMC207 e na le ts'ebetso e matla le e khethang khahlano le mycobacteria, 'me e sebetsa khahlano le lefuba la M. le sa utloeleng meriana le le hananang le lithethefatsi.Mokhoa oa ts'ebetso oa TMC207 o ikhethile har'a litlhare tse thibelang lefuba 'me o kenyelletsa ho thibela mycobacterial ATP synthase;ha e sebetse khahlanong le ATP synthase ea motho.TMC207 e na le ts'ebetso ea vivo mefuteng e mengata ea pele ea tšoaetso ea lefuba, e le 'ngoe hape e kopane le li-anti-TB tse ling,' me e na le ts'ebetso ea ho thibela likokoana-hloko mefuteng ea ts'oaetso ea lefuba.TMC207 e entsoe ka mehato e mehlano ho tloha ho 3-Phenylpropionic Acid le para-Bromoaniline.Ka mor'a ho thehoa ha amide, phekolo ea POCl3 le DMF tlas'a maemo a Vilsmeier-Hack e fane ka sehlahisoa sa 2-Chloroquinoline.Kalafo ka sodium methoxide, e lateloang ke condensation ka 3-(Dimethylamino) -1-(naphthalen-1-yl) propan-1-one, le karohano ea li-isomers e fane ka TMC207.
