Crizotinib Intermediate CAS 877399-00-3 Bohloeki ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) ka boleng bo phahameng, bohareng ba Crizotinib (CAS: 877399-52-5).Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine |
| Litlhaloso tse tšoanang | Crizotinib ea Mahareng;Tšilafalo ea Crizotinib Bromide;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 877399-00-3 |
| Foromo ea limolek'hule | Setšoantšo sa C13H10BrCl2FN2O |
| Boima ba Molek'hule | 380.04 g/mol |
| Melting Point | 108.0 ho isa ho 113.0 ℃ |
| Botenya | 1.643 |
| COA & MSDS | E fumaneha |
| Mohlala | E fumaneha |
| Tšimoloho | Shanghai, China |
| Sehlopha | Bohareng ba Crizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Bosehla bo Khanyang ho ea ho Phofo e Sehla ho ea ho Crystal | E lumellana |
| Melting Point | 108.0 ho isa ho 113.0 ℃ | E lumellana |
| Purity (Sebaka sa HPLC) | ≥98.0% | 99.1% |
| Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| 1 H NMR Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa sena se lekoa 'me se lumellana le litlhaloso | |
| Shelf Life | Lilemo tse 2 haeba li bolokiloe hantle | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
(R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine (CAS: 877399-00-3) e sebelisoa e le setsi sa bohareng ba Crizotinib (CAS: 877399-52-5).
Crizotinib ke sethethefatsi se khahlanong le mofets'e se fetohang alk (anaplastic lymphoma kinase) le ros1 (c-ros oncogene 1) inhibitor, e amoheloang bakeng sa kalafo ea mofuta o mong o seng o monyane oa cell lung carcinoma (NSCLC) USA le linaheng tse ling, le e ntse e etsa lithuto tse ngata tse lekang polokeho le katleho ea eona ho anaplastic big cell lymphoma, neuroblastoma, le lihlahala tse ling tse tsoetseng pele tse tiileng ho batho ba baholo le bana.
Crizotinib ke moriana oa kalafo o lebisitsoeng ho mofets'e o seng o monyane oa mofets'e oa matšoafo o hlahisitsoeng ke Pfizer, USA, secorri ke sethethefatsi sa moeli le se etsang nako lefapheng la kalafo e lebisitsoeng bakeng sa mofetše oa matšoafo.E ile ea amoheloa hore e bapatsoe United States ka Phato 2011 'me ea ngoloa litataisong tsa machaba tsa kalafo ea mofetše oa matšoafo qetellong ea selemo e le moriana oa pele bakeng sa bakuli ba ALK-positive.Co-approved with Crizotinib ke mokhoa oa pele oa ho hlahloba liphatsa tsa lefutso ho sebelisa fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, ena ke mokhoa o sebelisoang hona joale litekong tsa lefats'e tsa kliniki ho lemoha liphatsa tsa lefutso tsa EML4-ALK ho NSCLC.Tlhahlobo ena e tla thusa ho tseba bakuli ba ka ruang molemo kalafo ea Crizotinib.
Crizotinib ke khetho ea tyrosine kinase receptor inhibitor e sebelisoang kalafong ea linyeoe tse khethiloeng tsa mofets'e o seng o monyane oa lisele tsa matšoafo.Ke ATP competitive inhibitor ea tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) le ALK (cellular IC50 = 20 nM), tseo ka bobeli e leng lipheo tsa bohlokoa bakeng sa chemotherapy ea kankere.Ha Crizotinib e ne e lekoa bakeng sa selectivity khahlanong le li-kinase tse ling ho fumanoe hore e na le enzyme IC50's ka har'a li-multiples tsa 100 tsa c-MET bakeng sa 13 ea 120 kinases e lekiloeng.Litlhahlobong tsa lisele tsa cellular, Crizotinib e fumanoe e thibela RON (recepteur d'origine nantais) kinase e nang le fensetere ea 10-fold selectivity holim'a c-MET.Ka kakaretso, moemeli ona o thibela kholo ea lisele tsa tumor.XALKORI®(Crizotinib) ke moriana o fanoeng ke ngaka o sebelisetsoang ho alafa batho ba nang le mofetše o seng o monyane oa lisele tsa matšoafo (NSCLC) o hasaneng likarolong tse ling tsa 'mele mme o bakoa ke bofokoli ho mofuta o mong o bitsoang ALK (anaplastic lymphoma kinase) kapa mofuta o bitsoang ROS1.Ha ho tsejoe hore na XALKORI e bolokehile ebile e sebetsa ho bana.
