1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Bohloeki ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) e nang le boleng bo phahameng, bohareng ba Crizotinib (CAS: 877399- 52-5).Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | 1-Boc-4-(4-Bromopyrazol-1-yl) piperidine |
| Litlhaloso tse tšoanang | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino) -4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl) -4-Bromopyrazole;Tšilafalo ea Crizotinib 4 |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 877399-50-3 |
| Foromo ea limolek'hule | Setšoantšo sa C13H20BrN3O2 |
| Boima ba Molek'hule | 330.23 g/mol |
| Melting Point | 77.0 ho isa ho 81.0 ℃ |
| Botenya | 1.43 |
| Solubility | E qhibiliha ka Methanol |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Sehlopha | Bohareng ba Crizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | White Tiileng | White Tiileng |
| Melting Point | 77.0 ho isa ho 81.0 ℃ | E lumellana |
| Metsi ka Karl Fischer | <0.50% | 0.11% |
| Mokhoa oa Bohloeki / Analysis | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Mmisa | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Matshwao a Kotsi Xn - A Kotsi
Likhoutu tsa Kotsi 22 - E kotsi ha e koetsoe
1-Boc-4- (4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) e sebelisoa e le bohareng ba Crizotinib (CAS: 877399-52-5).Crizotinib (lebitso la khoebo Xalkori,) ke sethethefatsi se thibelang mofets'e se sebetsang joalo ka ALK (anaplastic lymphoma kinase) le ROS1 (c-ros oncogene 1) inhibitor, e amohetsoeng bakeng sa kalafo ea mofuta o mong o seng o monyane oa cell lung carcinoma (NSCLC) naheng ea Amerika. le linaha tse ling, 'me li ntse li etsa liteko tsa tleliniki tse lekang polokeho le katleho ea eona, e nanaplastic e kholo ea lisele tsa lymphoma, neuroblastoma, le lihlahala tse ling tse tiileng ho batho ba baholo le bana.
Ka Phato 2011, United States FDA e ile ea amohela Crizotinib (PF- 02341066) bakeng sa kalafo ea anaplastic lymphoma kinase (ALK) e ile ea hlophisa bocha mofetše oa matšoafo o se nang lisele tse nyane (NSCLC).Crizotinib ke ATP competitive inhibitor ea tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) le ALK (cellular IC50 = 20 nM), tseo ka bobeli e leng lipheo tsa bohlokoa bakeng sa chemotherapy ea kankere.Ha Crizotinib e ne e lekoa bakeng sa selectivity khahlanong le li-kinase tse ling ho fumanoe hore e na le enzyme IC50's ka har'a li-multiples tsa 100 tsa c-MET bakeng sa 13 ea 120 kinases e lekiloeng.Litlhahlobong tsa lisele tsa cellular, Crizotinib e fumanoe e thibela RON (recepteur d'origine nantais) kinase e nang le fensetere ea 10-fold selectivity holim'a c-MET.
