1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Bohloeki ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) e nang le boleng bo phahameng, bohareng ba Crizotinib (CAS: 877399-52 -5).Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | 1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole |
| Litlhaloso tse tšoanang | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Tšilafalo ea Crizotinib 16 |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 877399-73-0 |
| Foromo ea limolek'hule | Setšoantšo sa C13H20IN3O2 |
| Boima ba Molek'hule | 377.22 g/mol |
| Melting Point | 97℃ |
| Botenya | 1.60±0.10 g/cm3 |
| E hloahloa | Khanya e Imamela |
| Mocheso oa polokelo. | 2 ~ 8 ℃, Sireletsa Leseling |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Sehlopha | Bohareng ba Crizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Bosoeu ho isa ho Bosehla bo Khanyang bo Tiileng | White Tiileng |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| 1 H NMR Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| ESI+ | E lumellana | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) e nang le boleng bo phahameng, bohareng ba Crizotinib (CAS: 877399-52-5).Crizotinib ke moriana oa kalafo o lebisitsoeng ho mofets'e o seng o monyane oa mofets'e oa matšoafo o hlahisitsoeng ke Pfizer, USA, secorri ke sethethefatsi sa moeli le se etsang nako lefapheng la kalafo e lebisitsoeng bakeng sa mofetše oa matšoafo.E ile ea amoheloa hore e bapatsoe United States ka Phato 2011 'me ea ngoloa litataisong tsa machaba tsa kalafo ea mofetše oa matšoafo qetellong ea selemo e le moriana oa pele bakeng sa bakuli ba ALK-positive.Co-approved with Crizotinib ke mokhoa oa pele oa ho hlahloba liphatsa tsa lefutso ho sebelisa fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, ena ke mokhoa o sebelisoang hona joale litekong tsa lefats'e tsa kliniki ho lemoha liphatsa tsa lefutso tsa EML4-ALK ho NSCLC.Tlhahlobo ena e tla thusa ho tseba bakuli ba ka ruang molemo kalafo ea Crizotinib.ka lilemo tse 25, sena ke setlhare sa pele se lokelang ho sebelisoa ho phekola bakuli ba nang le mofetše oa sele ea matšoafo o tsoetseng pele kapa oa metastatic oo e seng o monyenyane oa lisele tsa matšoafo (NSCLC) e leng anaplastic lymphoma kinase (ALK) -positive joalokaha ho khethiloe ke tlhahlobo e lumelitsoeng ke SFDA.
Crizotinib (PF-02341066) Crizotinib ke c-Met e matla le ALK inhibitor, litekanyetso tsa IC50 ka har'a tlhahlobo ea lisele e ne e le 11 nM le 24 nM, ka ho latellana.Hape ke inhibitor e matla ea ROS1 e nang le boleng ba Ki bo ka tlase ho 0.025 nM.Crizotinib e ka etsa hore autophagy e kenelle liseleng tse fapaneng tsa kankere ea matšoafo ka ho thibela tsela ea STAT3.
