CAS 945667-22-1 Purity >99.0% (HPLC) API
Ruifu Chemical Supply Related Intermediates
CAS 361442-04-8
CAS 945667-22-1
(R)-1-Boc-3-Aminopiperidine CAS 188111-79-7
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7
Litlhaloso tse tšoanang | BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate |
Nomoro ea CAS | 945667-22-1 |
Nomoro ea KAtse | RF-PI1992 |
Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
Foromo ea limolek'hule | C18H25N3O2·H2O |
Boima ba Molek'hule | 333.43 |
Brand | Ruifu Chemical |
Ntho | Litlhaloso |
Ponahalo | Phofo e Tshweu |
boitsebiso | A: IR B: HPLC Nako ea ho Boloka |
Mokhoa oa Bohloeki / Analysis | >99.0% (HPLC, On Dried Basis) |
Litaba tsa Metsi (KF) | 5.3%~7.3% |
Masalla a ho Ignition | <0.20% |
Tšilafalo e le Mong | <0.50% |
Litšila ka Kakaretso | <1.00% |
Litšepe tse boima | <10ppm |
Arsenic (As) | <2ppm |
Microbiology | |
Kakaretso ea Plate Count | <1000cfu/g |
Yeast & Mold | <100cfu/g |
E. Coli | E mpe |
S. Aureus | E mpe |
Salmonella | E mpe |
Shelf Life | Likhoeli tse 24 |
Tekanyetso ea Teko | Maemo a Khoebo |
Tšebeliso | API;E sebelisetsoa ho phekola lefu la tsoekere la mofuta oa II |
Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo
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API (CAS: 945667-22-1) ke inhibitor e khethang le e fetolehang ea dipeptidyl peptidase-4 (DPP4) e ka sebelisoang ho nts'etsapele kalafo ea lefu la tsoekere la mofuta oa 2.Ke DPP4 inhibitor e khethang le e fetolehang e nang le IC50 ea 26 nM le Ki ea 1.3 nM.IC50 boleng: 26 nM.Sepheo: DPP4 in vitro: E na le inhibition kamehla Ki ea 1.3 nM bakeng sa inhibition ea DPP4, e matla ka makhetlo a 10 ho feta Sitagliptin (li-inhibitors tse ling tse peli tsa DPP4) tse nang le Ki ea 13 le 18 nM.Ho phaella moo, E bontša ho khetheha ho hoholo bakeng sa DPP4 ho feta bakeng sa li-enzyme tsa DPP8 kapa DPP9 (400- le 75-fold, ka ho latellana).Metablite e sebetsang ea eona e matla ka makhetlo a mabeli ho feta motsoali.Ka bobeli (CAS: 945667-22-1) le metabolite ea eona e khetha haholo (> 4000-fold) bakeng sa thibelo ea DPP4 ha e bapisoa le mefuta e meng ea li-protease.(CAS: 945667-22-1) e fokotsa ho senyeha ha hormone ea incretin glucagon-like peptide-1, ka tsela eo e ntlafatsa liketso tsa eona, 'me e amahanngoa le ts'ebetso e ntlafetseng ea β-cell le khatello ea secretion ea glucagon.in vivo: E sebetsa haholo. nakong ea ho fana ka lintlafatso tse ipapisitseng le lethal dose ho hlakoloa ha tsoekere maemong a fapaneng a 0.13-1.3 mg/kg ho litoeba tsa ob/ob tse amanang le taolo.
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