CAS 945667-22-1 Purity >99.0% (HPLC) API

Tlhaloso e Khutšoanyane:

CAS: 945667-22-1

Bohloeki: >99.0% (HPLC)

Ponahalo: Phofo e tšoeu

API, Boleng bo Phahameng, Tlhahiso ea Khoebo

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Related Intermediates
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CAS 945667-22-1
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(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Lintho tsa Lik'hemik'hale:

Litlhaloso tse tšoanang	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Nomoro ea CAS	945667-22-1
Nomoro ea KAtse	RF-PI1992
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C18H25N3O2·H2O
Boima ba Molek'hule	333.43
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e Tshweu
boitsebiso	A: IR B: HPLC Nako ea ho Boloka
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC, On Dried Basis)
Litaba tsa Metsi (KF)	5.3%~7.3%
Masalla a ho Ignition	<0.20%
Tšilafalo e le Mong	<0.50%
Litšila ka Kakaretso	<1.00%
Litšepe tse boima	<10ppm
Arsenic (As)	<2ppm
Microbiology
Kakaretso ea Plate Count	<1000cfu/g
Yeast & Mold	<100cfu/g
E. Coli	E mpe
S. Aureus	E mpe
Salmonella	E mpe
Shelf Life	Likhoeli tse 24
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API;E sebelisetsoa ho phekola lefu la tsoekere la mofuta oa II

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

API (CAS: 945667-22-1) ke inhibitor e khethang le e fetolehang ea dipeptidyl peptidase-4 (DPP4) e ka sebelisoang ho nts'etsapele kalafo ea lefu la tsoekere la mofuta oa 2.Ke DPP4 inhibitor e khethang le e fetolehang e nang le IC50 ea 26 nM le Ki ea 1.3 nM.IC50 boleng: 26 nM.Sepheo: DPP4 in vitro: E na le inhibition kamehla Ki ea 1.3 nM bakeng sa inhibition ea DPP4, e matla ka makhetlo a 10 ho feta Sitagliptin (li-inhibitors tse ling tse peli tsa DPP4) tse nang le Ki ea 13 le 18 nM.Ho phaella moo, E bontša ho khetheha ho hoholo bakeng sa DPP4 ho feta bakeng sa li-enzyme tsa DPP8 kapa DPP9 (400- le 75-fold, ka ho latellana).Metablite e sebetsang ea eona e matla ka makhetlo a mabeli ho feta motsoali.Ka bobeli (CAS: 945667-22-1) le metabolite ea eona e khetha haholo (> 4000-fold) bakeng sa thibelo ea DPP4 ha e bapisoa le mefuta e meng ea li-protease.(CAS: 945667-22-1) e fokotsa ho senyeha ha hormone ea incretin glucagon-like peptide-1, ka tsela eo e ntlafatsa liketso tsa eona, 'me e amahanngoa le ts'ebetso e ntlafetseng ea β-cell le khatello ea secretion ea glucagon.in vivo: E sebetsa haholo. nakong ea ho fana ka lintlafatso tse ipapisitseng le lethal dose ho hlakoloa ha tsoekere maemong a fapaneng a 0.13-1.3 mg/kg ho litoeba tsa ob/ob tse amanang le taolo.