Celecoxib CAS 169590-42-5 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Celecoxib (CAS: 169590-42-5) ka boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Celecoxib,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Celecoxib |
| Litlhaloso tse tšoanang | Celebrex;Celebra;Celecox;Batho bohle;Solexa;SC-58635;SC 58635;YM-177;4- [5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 169590-42-5 |
| Foromo ea limolek'hule | C17H14F3N3O2S |
| Boima ba Molek'hule | 381.37 g/mol |
| Melting Point | 160.0 ho isa ho 165.0 ℃ |
| Botenya | 1.43±0.10 g/cm3 |
| Ho qhibiliha ha Metsi | Ha e qhibilihe ka Metsing |
| Solubility | Ho qhibiliha haholo ka Methanol;E qhibiliha ka Ethanol |
| COA & MSDS | E fumaneha |
| Mohlala | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu | E lumellana |
| Tlhahlobo | 98.0~102.0% | 99.8% |
| Melting Point | 160.0 ho isa ho 165.0 ℃ | 162.2 ℃ |
| Metsi ka Karl Fischer | <0.50% | 0.11% |
| Masalla a ho Ignition | <0.20% | 0.05% |
| Litšepe tse boima (Pb) | ≤20ppm | <10ppm |
| Celecoxib Related Compound A | <0.40% | <0.20% |
| Celecoxib Related Compound B | <0.10% | <0.10% |
| Tšilafalo ea Motho ka Mong e sa Boleloeng | <0.10% | <0.10% |
| Litšila kaofela | <0.50% | 0.20% |
| Infrared Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| 1H NMR Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo ea Fluorinated, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Celecoxib
Setšoantšo sa C17H14F3N3O2S 381.4
4- [5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
TLHALOSO
Celecoxib e na le NLT 98.0% le NMT 102.0% ea C17H14F3N3O2S, e baloang ho latela anhydrous
TS'ELISO TS'OANE
• A. HO KHANYA HO INFRARED <197>: [HLOKOMELA-Mekhoa <197A>, <197K>, kapa <197M> tlas'a Infrared Absorption e ka sebelisoa.]
[HLOKOMELA-Haeba ponahalo e fumanoeng e bontša liphapang, qhala ntho e tla hlahlojoa le Reference Standard ka karohano ka joala ba isopropyl, e fetoha mouoane hore e ome, 'me u tlalehe ponahalo e ncha.]
• B. Nako ea ho boloka tlhōrō e kholo ea tharollo ea Sample e lumellana le ea tharollo ea Maemo, joalo ka ha e fumanoe ho Assay.
TLHOKOMELO
• TSAMAISO
Buffer: 2.7 g/L ea monobasic potassium phosphate e fetotsoeng ka asiti ea phosphoric ho pH ea 3.0 ± 0.2
Mohato oa Mobile: Methanol, acetonitrile, le Buffer (3:1:6)
Diluent: Methanol le metsi (3:1)
Tharollo ea ho tšoaneleha ha tsamaiso: 0.5 mg/mL ea USP
Celecoxib RS le 2.4 µg/mL e 'ngoe le e 'ngoe ea USP Celecoxib Related Compound A RS le USP Celecoxib Related Compound B RS in Diluent
Tharollo e tloaelehileng: 0.5 mg/mL ea USP Celecoxib RS ka Diluent
Tharollo ea mohlala: 0.5 mg/mL ea Celecoxib ka Diluent
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Mokhoa: LC
Sesebelisoa: UV 215 nm
Kholomo: 4.6-mm × 25-cm;5-µm e paka L11
Mocheso oa kholu: 60 °
Sekhahla sa phallo: 1.5 mL / min
Boholo ba ente: 25 µL
Nako ea ho matha: Hoo e ka bang makhetlo a 1.5 ho feta tlhoro ea celecoxib
Ho nepahala ha sistimi
Mehlala: Tharollo ea ho tšoaneleha ha Sisteme le tharollo e Tloaelehileng
Litlhoko tsa ho tšoaneleha
Qeto: NLT 1.8 pakeng tsa motsoako o amanang le celecoxib A le Celecoxib le NLT 1.8 pakeng tsa Celecoxib le Celecoxib e amanang le motsoako oa B, Tharollo ea ho tšoaneleha ha Sisteme
Phapang e amanang le maemo: NMT 0.73%, Tharollo e tloaelehileng
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala peresente ea C17H14F3N3O2S karolong ea Celecoxib e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × 100
rU = karabelo e phahameng ho tsoa ho Sample solution
rS = karabelo ea tlhōrō ho tsoa ho tharollo e tloaelehileng
CS = mahloriso a tharollo e tloaelehileng(mg/mL)
CU = mahloriso a tharollo ea Mohlala (mg/mL)
Mekhoa ea ho amohela: 98.0% ~ 102.0% motheong oa anhydrous
LITŠILA
Tšilafalo ea Inorganic
• LINTLHA TSE BOHLOKO: NMT 20 ppm
Diluent: Acetone le metsi (17:3)
Tharollo e tloaelehileng: Hlakola 1.0 mL ea Standard Lead Solution, e lokiselitsoeng joalokaha e laetsoe tlas'a Heavy Metals <231>, Li-Reagents tse Khethehileng, tse nang le Diluent ho 20 mL.
Mohlala oa tharollo: Qhala 0.50 g ea Celecoxib ka 20mL ea Diluent.
Tharollo e se nang letho: 20 ml ea Diluent
Tlhahlobo
Mehlala: Tharollo e tloaelehileng, Tharollo e se nang letho, le Tharollo ea Mohlala
Ho tharollo e 'ngoe le e' ngoe, eketsa 2 mL ea pH 3.5 Acetate Buffer e lokiselitsoeng joalokaha e laetsoe tlas'a Heavy Metals <231>, Method I. Kopanya, 'me u kenye tharollo e' ngoe le e 'ngoe 1.2 mL ea thioacetamide-glycerin base TS.Kopanya hang-hang, 'me u lumelle ho ema bakeng sa 2 min.Fetisa litharollo ka sefe ea boholo ba pore ea 0.45-µm.Bapisa matheba holim'a li-filters tse fumanoang ho tsoa ho e 'ngoe le e' ngoe ea tharollo.
Maemo a ho amohela: 'Mala o sootho-botšo oa letheba o hlahang ho Sample solution ha o matla ho feta oa letheba le hlahang tharollong ea Maemo.Teko ha e sebetse haeba Tharollo e Tloaelehileng e sa bontše 'mala o sootho-botšo ha o bapisoa le tharollo e se nang letho.
• MASALE A HO THUSA <281>: NMT 0.2%, ho sebedisa crucible ya platinum
Litšila tsa Organic
• MOSEBETSI
Buffer, Mobile phase, Diluent, Sistimi e loketseng tharollo, Sample solution, le Chromatographic system: Tsoela pele joalo ka ha ho laetsoe ho Assay.
Tharollo e tloaelehileng: 0.5 µg/mL ea USP Celecoxib RS ho Diluent
Ho nepahala ha sistimi
Mehlala: Tharollo ea ho tšoaneleha ha Sisteme le tharollo e Tloaelehileng
Litlhoko tsa ho tšoaneleha
Qeto: NLT 1.8 pakeng tsa motsoako o amanang le Celecoxib A le Celecoxib le NLT 1.8 pakeng tsa Celecoxib le Celecoxib e amanang le motsoako oa B, Tharollo ea ho tšoaneleha ha Sisteme
Karo-karolelano ea pontšo-ho-lerata: NLT 20, Tharollo e tloaelehileng
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Celecoxib e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × 100
rU = karabelo ea tlhoro bakeng sa ho se hloeke ho hong le ho hong ho Tharollo ea Mohlala
rS = karabelo e phahameng ea celecoxib ka tharollo e tloaelehileng
CS = mahloriso a celecoxib ka har'a tharollo e tloaelehileng (mg/mL)
CU = mahloriso a Celecoxib ho Sample solution (mg/mL)
Mekhoa ea ho amohela
Litšila tsa motho ka mong: Sheba Lethathamo la 1.
[HLOKOMELA-Hlokomela tlhoro efe kapa efe ea litšila e ka tlase ho 0.05%.]
Lethathamo la 1
| Lebitso | Nako ea ho Boloka Nako | Melao ea Kamohelo NMT (%) |
| Motsoako o amanang le Celecoxib Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | - |
| Motsoako o amanang le Celecoxib Bb | 1.1 | 0.10 |
| Tšilafalo ea motho ka mong e sa hlalosoang | - | 0.10 |
| Litšila kaofela | - | 0.5 |
e 4--[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
b 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
LITEKO TSEKO
• TLHALOSO EA METSI, Mokhoa oa I <921>: NMT 0.5%, ho sebelisoa sampole ea 400-mg
KEKELETSO LIHLOKO
• PAKARETSO LE HO BOLOKA: Boloka ka har'a lijalo tse thata, tse sirelelitsoeng khanya le mongobo.Boloka mocheso oa kamore
• LITEKELO TSA USP REFERENCE <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Setšoantšo sa C17H14F3N3O2S 381.4
USP Celecoxib Related Compound A RS
4- [5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
Setšoantšo sa C17H14F3N3O2S 381.4
USP Celecoxib Related Compound B RS
4- [3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
Setšoantšo sa C17H14F3N3O2S 381.4
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
| Matšoao a Kotsi | Xn - E Kotsi |
| Likhoutu tsa Kotsi | R20/21/22 - E kotsi ka ho hema, ho kopana le letlalo le haeba e koetsoe. |
| R52 - E kotsi ho dibopuwa tsa metsing | |
| R61 - E ka baka kotsi ho ngwana ya esong ho hlahe | |
| R60 - E ka senya thari | |
| Tlhaloso ea Tšireletseho | S22 - U se ke ua hema lerole. |
| S24/25 - Qoba ho kopana le letlalo le mahlo. | |
| S28 - Ka mor'a ho kopana le letlalo, hlatsoa hang-hang ka sesepa-suds e ngata. | |
| S37/39 - Apara liatlana tse loketseng le tšireletso ea mahlo / sefahleho | |
| Li-ID tsa UN | UN 3077 9 / PGIII |
| WGK Jeremane | 3 |
| RTECS | DB2944937 |
| Khoutu ea HS | 2935900090 |
| Sehlopha sa Likotsi | TS'OALANG |
Celecoxib le Rofecoxib ke tse peli tse sebelisoang hona joale COX-2 inhibitors.E ntlafalitsoe ka katleho ke GD Searle & Pfizer Co. (US,) e lokollotsoeng ka 1999, lebitso la khoebo: Celebrex.Celecoxib ke sethethefatsi se seng sa steroidal, se khahlanong le ho ruruha se nang le litlamorao tse matla tsa analgesic le anti-inflammatory, se bakang sekhahla se tlase sa liso tsa ka mpeng le mathata a mang.E sebelisoa tleliniking ho phekola lefu la masapo a manonyeletso le lefu la masapo a manonyeletso le ramatiki, ka karolo e thibelang ho ruruha, ho imolla matšoao a lefu la masapo a manonyeletso le ramatiki ea ramatiki.
Celecoxib (CAS: 169590-42-5), Bakeng sa liphallelo le tsamaiso ea osteoarthritis (OA), ramatiki ea ramatiki (RA), ramatiki ea bana ba ramatiki (JRA), ankylosing spondylitis, bohloko bo boholo, dysmenorrhea ea mantlha le adjunct ea molomo ho tlhokomelo e tloaelehileng ea bakuli. ka malapa a adenomatous polyposis.
Celecoxib (CAS: 169590-42-5) e na le phello e khahlanong le ho ruruha le ea analgesic ea li-NSAID.Ka lebaka la sebopeho sa eona sa lik'hemik'hale, e ka kopanngoa le COX-2, e thibelang COX-2 ka ho khetheha.Sehlopha sa eona sa phenyl se tlama le mocha oa hydrophobic oa COX-2, 'me hydrophilic sulfonamide ea eona e etsa ketane ea hydrogen e nang le 513 arginine le 90 histidine ka "pokothong e ka thōko" ea COX-2.E boetse e amana haufi-ufi le arginine sebakeng sa COX-2120 'me e bapala karolo ea ho thibela COX-2 ho fetola arachidonic acid ho prostaglandins e kotsi' meleng oa motho. -2, Celecoxib ha e khone ho kena ka molek'hule ea COX-1, leha e le ho thibela phetoho ea eona ea arachidonic acid ho prostaglandins. mathata a ho teneha gastric a li-NSAID tse sebelisoang hangata.
Celecoxib (CAS: 169590-42-5) e bontšoa bakeng sa phekolo ea osteoarthritis le ramatiki ea lefuba.Tšebeliso ea eona e thibetsoe ho batho ba nang le hypersensitivity ho sulfonamides kapa li-NSAID tse ling.E lokela ho sebelisoa ka hloko ho batho ba nang le lefu la sebete.Ho etsahala ho sebelisana le lithethefatsi tse ling tse susumetsang CYP2C9 (mohlala, rifampin rifampin) kapa ho qothisana lehlokoa le metabolism ka enzyme ena (mohlala, fluconazole, leflunomide).Litlamorao tse mpe tse atileng haholo ho celecoxib ke litlamorao tse bobebe ho isa ho tse itekanetseng tsa GI joalo ka dyspepsia, letšollo le bohloko ba ka mpeng.Litlamorao tse tebileng tsa GI le renal li etsahetse ka seoelo.
