Chloramphenicol CAS 56-75-7 Bohloeki ≥99.0% (HPLC) Bohloeki bo Phahameng
Phepelo ea Moetsi ka Bohloeki bo Phahameng le Tlhahiso ea Khoebo
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
| Lebitso la Lik'hemik'hale | Chloramphenicol |
| Litlhaloso tse tšoanang | D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
| Nomoro ea CAS | 56-75-7 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C11H12Cl2N2O5 |
| Boima ba Molek'hule | 323.13 |
| Melting Point | 149.0 ho isa ho 153.0 ℃ (lit.) |
| E hloahloa | Khanya e Imamela |
| Solubility | E qhibiliha Haholo ka Ethanol, Methanol, Acetone.E qhibiliha ka Ether, Chloroform.Ha e qhibilihe ka Benzene.Ha e Monyehe ka Metsing |
| Boemo ba ho Romela | E Rometsoe ka Tlas'a Mocheso o Tletseng |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo e Bosoeu ho isa ho e Khanyang |
| Boitsebiso A | Ho kenngoa ha infrared |
| Boitsebiso B | Nako ea ho boloka tlhoro e kholo ea chromatogram ea boitokisetso ba Assay e lumellana le e ho chromatogram ea Tokisetso e Tloaelehileng, joalo ka ha e fumanoe ho Assay. |
| Specific Optical Rotation | +17.0°~+20.0° |
| Melting Point | 149.0 ~ 153.0℃ |
| Crystallinity | E Kopana le Litlhoko |
| pH | 4.5~7.5 |
| Tšilafalo e le Mong | ≤0.50% |
| Litšila ka Kakaretso | ≤1.00% |
| Litšepe tse boima | ≤20ppm |
| Arsenic | ≤1ppm |
| Tahlehelo ka ho Omisa | ≤0.50% (105℃, lihora tse 3) |
| Masalla a ho Ignition | ≤0.10% |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC) |
| Tekanyetso ea Teko | Maemo a Khoebo;JP;USP |
Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli, mongobo.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol ha e na ka tlaase ho karolo ea 97.0 lekholong le ho feta 103.0 lekholong ea C11H12Cl2N2O5.
Ho paka le ho boloka-Ho boloka ka lijaneng tse thata.
Labeling-Moo e reretsoeng ho sebelisoa ho lokisa liforomo tse nang le ente kapa tse ling tse nyopa, leibole e bolela hore ha e hloeke kapa e tlameha ho sebetsoa nakong ea ho lokisoa ha mefuta e meng ea ente kapa e nyopa.
USP Reference standards <11>-
USP Chloramphenicol RS Tobetsa ho Sheba Sebopeho
USP Endotoxin RS
Boitsebiso-
A: Infrared Absorption <197K>.
B: Nako ea ho boloka tlhoro e kholo ea chromatogram ea boitokisetso ba Assay e lumellana le e ho chromatogram ea Tokisetso e Tloaelehileng, joalo ka ha e fumanoe ho Assay.
Sebaka sa ho qhibiliha <741>: pakeng tsa 149 le 153.
Potoloho e khethehileng <781S>: pakeng tsa +17.0 le +20.0.
Tharollo ea teko: 50 mg, e sa omisitsoeng, ka mL, ka joala bo se nang metsi.
Crystallinity <695>: e kopana le litlhoko.
Li-endotoxins tsa baktheria 85-Moo Chloramphenicol e reretsoeng ho sebelisoa ha ho etsoa liforomo tsa litekanyetso tse nang le ente, ha e na ho feta 0.2 USP Endotoxin Unit ka mg ea chloramphenicol.
Sterility 71- Moo leibole e bolelang hore Chloramphenicol ha e na likokoana-hloko, e kopana le litlhokahalo ha e lekoa joalo ka ha ho laetsoe bakeng sa Membrane Filtration tlas'a Teko ea Sterility ea Sehlahisoa hore e hlahlojoe, ntle le ho sebelisa 1 g ea mohlala o tiileng.
pH <791>: pakeng tsa 4.5 le 7.5, ka ho fanyeha ha metsi ho nang le 25 mg ka mL.
Chromatographic purity-Hlakola palo e lekantsoeng hantle ea Chloramphenicol ka methanol ho fumana tharollo ea teko e nang le 10 mg ka mL.Lokisetsa tharollo ea USP Chloramphenicol RS ka methanol e nang le 10 mg ka mL (Tharollo e Tloaelehileng A).Hlakola likaroloana tsa tharollo e Tloaelehileng A ka bongata ka methanol ho fumana tharollo e Tloaelehileng ea B e nang le 100 µg ka mL le Tharollo e Tloaelehileng ea C e nang le 50 µg ka mL.Sebelisa likarolo tse arohaneng tsa 20-µL tsa tharollo ea teko le litharollo tse tloaelehileng tsa B le C ho poleiti e loketseng ea lera le tšesaane la chromatographic (sheba Chromatography 621), e koahetsoeng ka lera la 0.25-mm ea motsoako oa silika oa chromatographic.Theha chromatogram tsamaisong ea solvent e nang le motsoako oa chloroform, methanol, le glacial acetic acid (79:14:7) ho fihlela karolo e ka pele ea solvent e sisinyehile hoo e ka bang tharo-nneng ea bolelele ba poleiti.Tlosa poleiti ka phaposing, e omelle moeeng, 'me u hlahlobe ka tlas'a lebone le lekhutšoane la UV: sebaka se seng le se seng ntle le sebaka se ka sehloohong se fumanoeng ka tharollo ea teko ha se fete ka boholo kapa boholo ba sebaka se ka sehloohong se fumanoeng ho Standard Solution B (1% ), 'me kakaretso ea litšila tse emeloang ke matheba ohle ntle le sebaka se ka sehloohong, ho ipapisitsoe le matla a matheba a joalo le matla a matheba a mantlha a fumanoeng ho tsoa ho litekanyetso tsa B le C, ha e fete 2% .
Tlhahlobo-
Mobile phase-Lokisetsa motsoako o loketseng o tlhotliloeng oa metsi, methanol, le glacial acetic acid (55:45:0.1).Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Tlhophiso e tloahelehileng- Hlakola tekanyo e lekantsoeng e nepahetseng ea USP Chloramphenicol RS ho Mobile phase, 'me u hlapolle ka bongata, le ha ho hlokahala, ka Mobile phase ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 80 µg ka mL.Sefa karolo ea tharollo ena ka sefe ea 0.5-µm kapa porosity e ntle haholoanyane, 'me u sebelise sefe e hlakileng joalo ka Tokiso e Tloaelehileng.
Boitokisetso ba tlhahlobo- Fetisetsa hoo e ka bang 200 mg ea Chloramphenicol, e lekantsoeng ka nepo, ho botlolo ea volumetric ea 100-mL, eketsa karolo ea Mobile ho molumo, 'me u kopanye.Fetisetsa 4.0 mL ea tharollo e hlahisoang ho botlolo ea volumetric ea 100-mL, hlapolla ka karolo ea Mobile ho ea bophahamong, 'me u kopanye.Sefa karolo ea tharollo ena ka 0.5-µm kapa filthara ea porosity e ntle, 'me u sebelise filtrate e hlakileng e le tokisetso ea Assay.
Chromatographic system (sheba Chromatography <621>)-Mokelikeli oa chromatograph o na le mochine oa 280-nm le kholomo ea 4.6-mm × 10-cm e nang le 5-µm packing L1.Sekhahla sa phallo ke hoo e ka bang 1 mL ka motsotso.Chromatograph ea Tekanyetso ea Tekanyetso, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe tlasa Tsamaiso: katleho ea kholomo e lekantsoeng ho tsoa tlhorong ea analyte ha e ka tlase ho lipoleiti tsa theoretical tse 1800, ntlha ea mohatla ha e fete 2.0, mme kheloha e lekanyelitsoeng bakeng sa liente tse phetoang ha se joalo. ho feta 1.0%.
Ts'ebetso--[note-Sebelisa libaka tse phahameng haholo moo likarabo tse phahameng li bontšitsoeng.] Kenya livolume tse lekanang ka thoko (hoo e ka bang 10 µL) tsa tokisetso e tloaelehileng le boitokisetso ba Assay ho chromatograph, rekota li-chromatogram, 'me u lekanye likarabo tsa litlhoro tse kholo.Bala palo, ka mg, ea C11H12Cl2N2O5 karolong ea Chloramphenicol e nkiloeng ka foromo:
2.5C(rU / rS)
moo C e leng mahloriso, ho µg ka mL, ea USP Chloramphenicol RS ho tokisetso e Tloaelehileng, le rU le rS e leng likarabelo tse phahameng tse fumanoeng ho tsoa ho tokiso ea Assay le ho hlophisoa ha Maemo, ka ho latellana.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl) propan-2-yl]acetamide [56-75-7]
Chloramphenicol e na le seng ka tlase ho 980 mg (matla) le eseng ho feta 1020 mg (potency) ka mg, e baloang motheong o omisitsoeng.Matla a Chloramphenicol a hlalosoa e le boima (matla) a chloramphenicol (C11H12Cl2N2O5).
Tlhaloso Chloramphenicol e hlaha e le bosoeu ho isa ho bosehla bo bosoeu, likristale kapa phofo ea crystalline.
E qhibiliha ka bolokolohi ho methanol le ethanol (99.5), 'me e qhibiliha hanyenyane metsing.
Ho tsebahatsa (1) Etsa qeto ea hore na ho na le mofuta ofe oa tharollo ea sampole e fumanoeng ho Assay joalokaha e laetsoe tlas'a Ultraviolet-visible Spectrophotometry <2.24>, 'me u bapise spectrum le Reference Spectrum kapa spectrum ea tharollo ea Chloramphenicol RS e lokiselitsoeng ka mokhoa o ts'oanang. mohlala oa tharollo: spectra ka bobeli li bonts'a matla a ts'oanang a ho monya ka bolelele bo tšoanang.
(2) Etsa qeto ea hore na "Chloramphenicol" ea "infrared absorption spectrum") joalokaha e laetsoe ka mokhoa oa potassium bromide disk tlas'a Infrared Spectrophotometry <2.25>, 'me u bapise spectrum le Reference Spectrum kapa Chloramphenicol RS. linomoro tsa maqhubu.
Potoloho ea mahlo <2.49> [a]20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Sebaka sa ho qhibiliha <2.60> 150 ~ 155 ℃
Bohloeki (1) Litšepe tse boima <1.07>-Tsoela pele ka 1.0 g ea Chloramphenicol ho ea ka Method 2, 'me u etse tlhahlobo.Lokisetsa tharollo ea taolo ka 2.5 mL ea Standard Lead Solution (e seng ho feta 25 ppm).
(2) Arsenic <1.11> -Lokisetsa tharollo ea teko ka 2.0 g ea Chloramphenicol ho ea ka Method 4, 'me u etse tlhahlobo (eseng ho feta 1 ppm).
(3) Lintho tse amanang le tsona-Hlakola 0.10 g ea Chloramphenicol ka 10 ml ea methanol, 'me u sebelise tharollo ena e le mohlala oa tharollo.Pipete 1 ml ea tharollo ea sampole, eketsa methanol ho etsa 100 ml hantle, 'me u sebelise tharollo ena e le tharollo e tloaelehileng (1).Pipete 10 ml ea tharollo e tloaelehileng (1), eketsa methanol ho etsa 20 ml hantle, 'me u sebelise tharollo ena e le tharollo e tloaelehileng (2).Etsa tlhahlobo ka litharollo tsena joalokaha ho laetsoe tlas'a Thin-layer Chromatography <2.03>.Spot 20 ml ka 'ngoe ea tharollo ea sampole le tharollo e tloaelehileng (1) le (2) poleiting ea silika ea gel e nang le sesupo sa fluorescent bakeng sa chromatography ea lera le tšesaane, hlahisa poleiti ka motsoako oa chloroform, methanol le acetic acid (100) ( 79:14:7) ho ea bohōle ba lisenthimithara tse 15, 'me u omise poleiti moeeng.Hlahloba ka tlas'a leseli la ultraviolet (bolelele bo boholo: 254 nm): matheba ntle le sebaka sa mantlha le letheba le fumanoeng ho tsoa ho sampuli ea tharollo ha li matla ho feta sebaka se fumanoeng ho tsoa tharollong e tloaelehileng (1), 'me kakaretso e felletseng. ea matheba ana a tsoang ho sampuli ea tharollo ha e fete 2.0%.
Tahlehelo ka ho omisa <2.41> Ha e fete 0.5% (1 g, 105℃, lihora tse 3).
Masalla ha a khangoa <2.44> Ha a fete 0.1%(1 g).
Assay Leka ka nepo palo ea Chloramphenicol le Chloramphenicol RS, e lekanang le hoo e ka bang 0.1 g (matla), qhala e 'ngoe le e 'ngoe ka 20 ml ea methanol, 'me u kenye metsi ho etsa 100 ml hantle.Pipeta 20 ml ka e 'ngoe ea litharollo tsena, ebe u eketsa metsi ho etsa 100 ml hantle.Pipet 10 ml e 'ngoe le e' ngoe ea litharollo tsena, eketsa metsi ho etsa 100 ml hantle, 'me u sebelise litharollo tsena e le mohlala oa tharollo le tharollo e tloaelehileng.Etsa qeto ea li-absorbents, AT le AS, ho 278 nm ea tharollo ea sampuli le tharollo e tloaelehileng joalokaha e laetsoe tlas'a Ultraviolet-visible Spectrophotometry <2.24>.
Palo [mg (potency)] ea chloramphenicol (C11H12Cl2N2O5)
＝ MS × AT/AS × 1000
MS: Palo [mg (potency)] ea Chloramphenicol RS
nkeloa
Lijana le polokelo Lijana-Tight lijana.
Likhoutu tsa Kotsi R45 - E ka baka mofetše
R11 - E tuka Haholo
R39/23/24/25 -
R23/24/25 - Chefo ka ho hema, ka ho kopana le letlalo le haeba e koetsoe.
Tlhaloso ea Tšireletseho S53 - Qoba ho pepeseha - fumana litaelo tse khethehileng pele u li sebelisa.
S45 - Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ho ngaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S16 - Qoba hole le mehloli ea mollo.
S36/37 - Apara liaparo tsa tšireletso tse loketseng le liatlana.
UN ID 2811
WGK Jeremane 3
RTECS AB6825000
FLUKA BRAND F DIKHOUTU 3-10
TSCA Ho joalo
HS Code 2941400000
Sehlopha sa 3 sa Kotsi
Chefo LD50 molomo ka rat: 2500mg/kg
P501: Lahla likahare/ sets'oants'o setsing se lumelletsoeng sa ho lahlela litšila.
P260: Se ke oa hema lerole/ mosi/ khase/ moholi/ mouoane/ sefafatsi.
P270: U se ke ua ja, ua noa kapa ua tsuba ha u sebelisa sehlahisoa sena.
P202: Se ke oa tšoara ho fihlela mehato eohle ea tšireletso e balletsoe le ho utloisisoa.
P201: Fumana litaelo tse khethehileng pele u li sebelisa.
P264: Hlatsoa letlalo hantle ka mor'a ho tšoara.
P280: Apara litlelafo tse sireletsang/ liphahlo tse sireletsang mahlo/ tse sireletsang sefahleho.
P308 + P313: HAEBA o pepesitsoe kapa o amehile: Fumana keletso/ tlhokomelo ea bongaka.
P405: Lebenkele le notletsoe.
Shanghai Ruifu Chemical Co., Ltd. ke mofani ea ka sehloohong oa Chloramphenicol (CAS: 56-75-7) ka boleng bo phahameng.Chloramphenicol ke lithibela-mafu tse ngata tse thibelang likokoana-hloko, e leng khetho ea pele bakeng sa phekolo ea typhoid le paratyphoid, ea bobeli, e sebelisetsoa ho phekola mafu a sa tšoaneng a tšoaetsanoang a bakoang ke likokoana-hloko tse nang le kutloelo-bohloko.Ka lebaka la karabelo e matla e mpe hona joale e sebelisoa hanyane le hanyane.The antibacterial spectrum, mosebetsi le ts'ebeliso li tšoana le chloramphenicol bakeng sa phekolo ea Salmonella Typhi, Shigella, Escherichia coli, influenza, Brucella, mafu a matšoafo a bakoang ke cocci le lithibela-mafu tse ling tse thibelang tšoaetso.Chloramphenicol e sebelisoa haholo ho phekola tšoaetso ea moroto, Pneumonia, tšoaetso ea ka mpeng le septicemia e bakoang ke libaktheria tse nang le kutloelo-bohloko, hammoho le marotholi a ka ntle a mahlo le marotholi a litsebe.
UN3249 Meriana, e tiileng, e chefo, nos, Sehlopha sa Kotsi: 6.1;Labels: 6.1-Lisebelisuoa tse chefo.UN2811 Lintho tse chefo, lintho tse phelang, li-nos, Sehlopha sa Kotsi: 6.1;Labels: 6.1- Lisebelisoa tse chefo, Lebitso la Tekniki lea Hlokahala.
