SBE-β-CD CAS 182410-00-0 Betadex Sulfobutyl Ether Sodium Assay 95.0~105.0%
Ruifu Chemical ke moetsi ea ka sehloohong oa Betadex Sulfobutyl Ether Sodium (SBE-β-CD; Captisol) (CAS: 182410-00-0) e nang le boleng bo phahameng.Ruifu e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, ts'ebeletso e ntle haholo, palo e nyane le e ngata e fumanehang.Reka Betadex Sulfobutyl Ether Sodium,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Betadex Sulfobutyl Ether Sodium |
| Litlhaloso tse tšoanang | SBE-β-CD;SBE-beta-CD;Captisol;Sodium Sulfobutylether β-Cyclodextrin;Sodium Sulphobutylether-beta-Cyclodextrin;Sulfobutylether beta-Cyclodextrin;Beta-Cyclodextrin Sulfobutyl Ethers Sodium Salts;β-Cyclodextrin Sulfobutyl Ethers Sodium Salts |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 182410-00-0 |
| Foromo ea limolek'hule | C42H70O35•xNa•x(C4H9O3S) |
| Boima ba Molek'hule | (1134.99).x(22.99).x(137.17) g/mol |
| Melting Point | 202.0~204.0℃(Dec.) |
| Solubility | E qhibilihang ka Metsing.Ha e qhibilihe ka har'a Acetone, Methanol, Chloroform |
| Khoutu ea HS | 3505100000 |
| COA & MSDS | E fumaneha |
| Mohlala | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo ea Amorphous e tšoeu ho isa ho e tšoeu | Ikamahanye |
| Boitsebiso ba IR | Lihlopha tsa ho monya tse tšoanang le tsa USP Betadex Sulfobutyl Ether Sodium RS | Ikamahanye |
| Boitsebiso ba HPLC | Nako ea ho boloka tlhōrō e kholo ea tharollo ea sampole e lumellana le tharollo e tloaelehileng | Ikamahanye |
| Karolelano ea Degree ea Phapanyetsano | Ikamahanye | Ikamahanye |
| Sodium ea boitsebiso | Lekola tlhahlobo e ntle bakeng sa sodium | Ikamahanye |
| Tlhahlobo | 95.0%~105.0% | 99.49% |
| Beta Cyclodextrin | ≤0.10% | Ha e fumanwe |
| 1,4-Butane Sultone | ≤0.5ppm | 0.19ppm |
| Sodium Chloride | ≤0.20% | 0.003% |
| 4-Hydroxybutane-1-Sulfonic Acid | ≤0.09% | Ha e fumanwe |
| Bis(4-Sulfobtyl) Ether Disodium | ≤0.05% | Ha e fumanwe |
| Likokoana-hloko tsa Endotoxins | ≤20EU/g | <5EU/g |
| Palo eohle ea Aerobic Microbial Count | ≤100cfu/g | <10cfu/g |
| Kakaretso ea Mould e Kopantsoeng le Litomoso li Baloa | ≤50cfu/g | <10cfu/g |
| Escherichia Coli | Ho ba sieo | Ha e fumanwe |
| Ho Hlakola ha Tharollo | 30%(w/v) tharollo e hlakile mme ha e le hantle ha e na likaroloana tsa lintho tse tsoang kantle ho naha. | Ikamahanye |
| Karolelano ea Degree ea Phapanyetsano | 6.2~6.9 | 6.5 |
| Tlhōrō ea I | 0.0~0.3 | 0 |
| Tlhōrō ea II | 0.0~0.9 | 0.62 |
| Tlhōrō ea III | 0.5~5.0 | 1.41 |
| Tlhōrō ea IV | 2.0~10.0 | 4.46 |
| Tlhōrō ea V | 10.0-20.0 | 11.72 |
| Tlhōrō ea VI | 15.0 ~ 25.0 | 20.75 |
| Tlhōrō ea VII | 20.0~30.0 | 29.04 |
| Tlhōrō ea VIII | 10.0~25.0 | 21.59 |
| PeakI X | 2.0~12.0 | 7.83 |
| Tlhōrō ea X | 0.0~4.0 | 2.57 |
| pH | 4.0~6.8 | 4.8 |
| Litaba tsa Metsi | ≤10.0% | 4.9% |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa sena ka tlhahlobo se lumellana le USP35 e tloaelehileng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng hantle, 'me u boloke sebakeng se pholileng, se omeletseng (2~8℃) le se nang le moea o motle hole le lintho tse sa lumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Betadex Sulfobutyl Ether Sodium
C42H70−nO35 · (C4H8SO3Na)n 2163 ha n = 6.5
Beta cyclodextrin sulfobutyl ethers, letsoai la sodium;
Beta cyclodextrin sulfobutyl ether sodium [182410-00-0].
TLHALOSO
Betadex Sulfobutyl Ether Sodium e lokiselitsoe ka alkylation ea betadex ho sebelisa 1,4-butane sultone tlas'a maemo a motheo.
Kakaretso ea tekanyo ea ho fetola betadex ke NLT 6.2 le NMT 6.9.
E na le NLT 95.0% le NMT 105.0% ea C42H70−nO35 · (C4H8SO3Na)n (n = 6.2–6.9), e baloang ho latela anhydrous.
TS'ELISO TS'OANE
• A. HO AMOHELA INFORARED <197K>
• B. Nako ea ho boloka tlhōrō e kholo ea tharollo ea Mohlala e lumellana le ea tharollo e tloaelehileng, joalokaha e fumanoa ho Assay.
• C. E kopana le ditlhoko tsa teko bakeng sa Average Degree of Substitution.
• D. LITEKO KAKARETSO TSA BOITSEBISO, Sodium 〈191〉
TLHOKOMELO
• TSAMAISO
Mokhahlelo oa selefouno: 0.1 M potassium nitrate ka motsoako oa acetonitrile le metsi (1:4)
Tharollo e tloaelehileng: 10 mg/mL ea USP Betadex Sulfobutyl Ether Sodium RS in Mobile phase
Tharollo ea mohlala: 10 mg / mL ea Betadex Sulfobutyl Ether Sodium in Mobile phase
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Mokhoa: LC
Detector: index ea refractive
Mocheso oa mochine: 35 ± 2 °
Kholomo: 7.8-mm × 30-cm kholomo ea tlhahlobo;ho paka L37.[HLOKOMELA-Hlatsoa kholomo ka tharollo ea acetonitrile le metsi (1:9) qetellong ea letoto la lipapali.]
Sekhahla sa phallo: 1.0 mL/min
Boholo ba ente: 20 µL
Ho tšoaneleha ha tsamaiso .
Mohlala: Tharollo e tloaelehileng
Litlhoko tsa ho tšoaneleha
Tekanyetso e amanang le maemo: NMT 2.0%
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala peresente ea betadex sulfobutyl ether sodium [C42H70−nO35 · (C4H8SO3Na)n] karolong ea Betadex Sulfobutyl Ether Sodium e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × 100
rU = karabelo e phahameng ea betadex sulfobutyl ether
sodium e tsoang ho Sample solution
rS = karabelo e phahameng ea betadex sulfobutyl ether
sodium e tsoang ho Standard solution
CS = mahloriso a USP Betadex Sulfobutyl Ether
Sodium RS ka har'a tharollo e tloaelehileng (mg/mL)
CU = mahloriso a Betadex Sulfobutyl Ether Sodium ka Sample solution (mg/mL)
Mekhoa ea ho amohela: 95.0% ~ 105.0% motheong oa anhydrous
LITŠILA
• LITŠEPE TSE BOHLOKO, Mokhoa oa II <231>: NMT 5 ppm
• LIMIT OF BETA CYCLODEXTRIN (BETADEX)
Tharollo A: 25 mm sodium hydroxide
Tharollo B: 250 mM sodium hydroxide le 1 M potassium nitrate
Mohato oa Mobile: Sheba Tafole ea 1.
Lethathamo la 1
| Nako (mets) | Tharollo A (%) | Tharollo B (%) |
| 0 | 100 | 0 |
| 4 | 100 | 0 |
| 5 | 0 | 100 |
| 10 | 0 | 100 |
| 11 | 100 | 0 |
| 20 | 100 | 0 |
Tharollo e tloaelehileng: 2 µg/mL ea USP Beta Cyclodextrin RS
Tharollo ea mohlala: 2 mg/mL ea Betadex Sulfobutyl Ether Sodium
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi le Ion Chromatography <1065>.)
Mokhoa: IC
Detector: Pulsed amperometry (sele ea amperometric e nang le elektrode e sebetsang ea khauta le elektrode ea referense ea silevera)
Kholomo
Molebeli: 4.0-mm × 5-cm anion-exchange;ho paka L61
Tlhahlobo: 4.0-mm × 25-cm anion-exchange;
ho paka L61
Mocheso oa kholomo: 50 ± 2 °
Sekhahla sa phallo: 1.0 mL/min
Boholo ba ente: 20 µL
Waveform bakeng sa detector ea pulsed amperometric: Bona Lethathamo la 2.
Lethathamo la 2
| Nako (s) | Motlakase (V) |
| 0.00 | 0.10 |
| 0.30 | Qala ho kopanya |
| 0.50 | 0.10 |
| 0.50 | Emisa ho kopanya |
| 0.51 | 0.60 |
| 0.60 | -0.60 |
| 0.65 | -0.60 |
Ho nepahala ha sistimi
Mohlala: Tharollo e tloaelehileng
Litlhoko tsa ho tšoaneleha
Tekanyetso e amanang le maemo: NMT 5.0%
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala peresente ea beta cyclodextrin (betadex) karolong ea Betadex Sulfobutyl Ether Sodium e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × F × 100
rU = karabelo e phahameng ea beta cyclodextrin ho tsoa ho Sample solution
rS = karabelo e phahameng ea beta cyclodextrin ho tsoa ho Standard solution
CS = mahloriso a USP Beta Cyclodextrin RS ka har'a tharollo e tloaelehileng (µg/mL)
CU = mahloriso a Betadex Sulfobutyl Ether Sodium ka Sample solution (mg/mL)
F = ntlha ea phetoho (10-3 mg/µg)
Maemo a kamohelo: NMT 0.1%
• LIMIT EA 1,4-BUTANE SULTONE
Tharollo e tloaelehileng ea ka hare: 0.25 µg/mL ea diethyl sulfone
Tharollo e tloaelehileng ea setoko A: 0.5 µg/mL ea 1,4-butane sultone
Tharollo e tloaelehileng ea setoko B: 1.0 µg/mL ea 1,4-butane sultone
Tharollo e tloaelehileng ea setoko C: 2.0 µg/mL ea 1,4-butane sultone
Sample stock solution: 250 mg/mL ea Betadex Sulfobutyl Ether Sodium ka har'a tharollo e tloaelehileng ea ka hare
Tharollo e se nang letho, le Mehlala ea tharollo A, B, C, le D:
Latela Letlapa la 3 ho beha bongata ba tharollo e tloaelehileng ea ka Hare, tharollo e 'ngoe le e 'ngoe ea Setoko se Tloaelehileng, Sample stock solution, metsi, kapa methylene chloride ka har'a phapu e 'ngoe le e 'ngoe ea teko ea khalase e nang le setopo.[HLOKOMELA-A screw-capped, 10-mL test tube e loketse.] Kopanya holim'a motsoako oa vortex tube e 'ngoe le e' ngoe ea teko bakeng sa 30 s, 'me u e lumelle hore e eme bonyane metsotso e 5 kapa ho fihlela karohano e feletseng ea mohato.Hlakola karolo ea manyolo ka har'a vial ea GC ebe u tiisa.[HLOKOMELA-Ka tlhokomelo e kholo nka bonyane bo ka khonehang ba karolo ea metsi.] Lipalo tse ekelitsoeng tsa 1,4-butane sultone ho Sample solutions A, B, C, and D ke 0.5, 1.0, 2.0, le 0 µg, ka ho latellana.
Lethathamo la 3
| Lebitso la Mohlala | Tharollo 1 E kentsoe (mL) | Tharollo 2 E kentsoe (mL) | Methylene Chloride E Eketsehile (mL) |
| Tharollo e se nang letho | Tharollo ea maemo a ka hare, 4.0 | Metsi, 1.0 | 1.0 |
| Tharollo ea mohlala A | Mohlala oa tharollo ea stock, 4.0 | Tharollo e tloaelehileng ea setoko A, 1.0 | 1.0 |
| Tharollo ea mohlala B | Mohlala oa tharollo ea stock, 4.0 | Tharollo e tloaelehileng ea setoko B, 1.0 | 1.0 |
| Tharollo ea mohlala C | Mohlala oa tharollo ea stock, 4.0 | Tharollo e tloaelehileng ea setoko C, 1.0 | 1.0 |
| Tharollo ea mohlala D | Mohlala oa tharollo ea stock, 4.0 | Metsi, 1.0 | 1.0 |
[HLOKOMELA-Lokisetsa hang-hang pele o sebelisoa.]
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Mokhoa: GC
Mohloli: Ionization ea mollo
Kholomo: 0.32-mm × 25-m fused-silica capillary column;0.5-µm lera la mokhahlelo oa G46
Mocheso
Mosireletsi: 270 °
Kou ea ente: 200 °
Kholomo: Sheba lenaneo la mocheso ho Lethathamo la 4
Lethathamo la 4
Thempereichara ea Pele (°) Sebaka sa Mocheso (°/min) Mocheso oa ho Qetela (°) Ho Tšoara Nako ka Mocheso oa ho Qetela (min)
100 10 200 -
200 35 270 5
Khase e tsamaisang thepa: Helium, hangata e le khatellong ea 12 psi inlet
Boholo ba ente: 1.0 µL
Mofuta oa ente: Ente e sa arohaneng bakeng sa 0.5 min, ebe e aroloa ho 50 mL / min.[HLOKOMELA-Ho khothaletsoa hore ho sebelisoe mochini o etsang ente e se nang petsoha.]
Ho nepahala ha sistimi
Mohlala: Mohlala oa tharollo B
[HLOKOMELA-Linako tse lekanyelitsoeng tsa ho boloka diethyl sulfone le 1,4-butane sultone ke 0.7 le 1.0, ka ho latellana.]
Litlhoko tsa ho tšoaneleha
Tekanyetso e amanang le maemo: NMT 10.0%
Tlhahlobo
Mehlala: Tharollo e se nang letho, Mehlala ea tharollo A, B, C, le D
Lokisa karo-karolelano ea likarabelo tse phahameng tsa 1,4-butane sultone ho diethyl sulfone ho Sample solution A, B, C, kapa D ka ho tlosa karolelano ea likarabelo tse phahameng tsa 1,4-butane sultone ho ethyl sulfone ka tharollong ea Blank. .Rala karo-karolelano e lokisitsoeng ea karabelo e phahameng ea 1,4-butane sultone ho karabelo e phahameng ea diethyl sulfone ho Mohlala oa tharollo A, B, C kapa D, khahlano le bongata bo ekelitsoeng, ho µg, ba 1,4-butane sultone.Eketsa mola o kopanyang lintlha ho kerafo ho fihlela o kopana le axis ea bongata.Sebaka se pakeng tsa ntlha ena le mateano a lilepe se emela bongata ba 1,4-butane sultone, A, ho µg, karolong ea 4-mL ea Sample stock solution.Bala litaba tsa 1,4-butane sultone karolong ea Betadex Sulfobutyl Ether Sodium e nkiloeng:
Sephetho = A/(VExt × CU × F)
A = ikemiselitse ka holimo
VExt = bophahamo ba modumo ea Sample stock solution e sebelisitsoeng mohatong oa ho ntša, 4.0 mL
CU = mahloriso a Betadex Sulfobutyl Ether Sodium ka Sample stock solution (mg/mL)
F = ntlha ea phetoho (10-3 g/mg)
Mekhoa ea ho amohela: hydroxybutane-1-sulfonic acid, kapa NMT 0.5 ppm
• MOEDI OA SODIUM CHLORIDE, 4-HYDROXYBUTANE-1-SULFONIC ACID, LE BIS(4-SULFOBUTYL) ETISODIUM
Tharollo A: 5 mM sodium hydroxide, degas ka sekepeng se koetsoeng bakeng sa 15 min
Tharollo B: 25 mM sodium hydroxide, degas ka sekepeng se koetsoeng bakeng sa 15 min
Mohato oa Mobile: Sheba Tafole 5
Lethathamo la 5
| Nako (mets) | Tharollo A (%) | Tharollo B(%) |
| 0 | 100 | 0 |
| 4 | 100 | 0 |
| 10 | 70 | 30 |
| 24 | 70 | 30 |
| 25 | 100 | 0 |
| 40 | 100 | 0 |
Tharollo ea ho hlatsoa litšiea A: 50 mM sodium citrate
Tharollo ea ho hlatsoa litšiea B: 150 mm sodium hydroxide
Tharollo e tloaelehileng: Lokisetsa tharollo e nang le metsoako e tsejoang ea 8 µg/mL ea USP Sodium Chloride RS, 4µg/mL ea 4-hydroxybutane-1-sulfonic acid, le 4 µg/mL ea bis(4-sulfobutyl) ether disodium.
Tharollo ea mohlala: 4 mg / mL ea Betadex Sulfobutyl Ether Sodium
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi le Ion Chromatography <1065>.)
Mokhoa: IC
Mofuputsi: Ho khanna
Boemo: 30 µS
Hona joale: 100 mA
Kholomo: [HLOKOMELA-Qetellong ea e 'ngoe le e' ngoe ea ho matha, hloekisa kholumo ka ho sebelisa Kholomo ea ho hlatsoa tharollo A ka tekanyo ea phallo ea 1 mL / min bakeng sa 35 min ebe u sebelisa Kholomo ea ho hlatsoa tharollo B ka tekanyo e tšoanang ea 35 min.]
Molebeli: 4.0-mm × 5.0-cm anion-exchange;ho paka L61
Tlhahlobo: 4.0-mm × 25-cm anion-exchange;ho paka L61
Mocheso oa kholu: 30 °
Mohatelli: Micromembrane anion autosuppressor1 kapa mokhoa o loketseng oa khatello ea lik'hemik'hale
Mohatelli: Ho hatella ka ho iketsa
Sekhahla sa phallo: 1.0 mL/min
Boholo ba ente: 20 µL
Ho nepahala ha sistimi
Mohlala: Tharollo e tloaelehileng
[HLOKOMELA-Linako tse amanang le ho boloka li fanoe bakeng sa tlhahisoleseding feela.Linako tse lekanyelitsoeng tsa ho boloka ion 4-hydroxybutane-1-sulfonate ion, chloride ion, le bis(sulfobutyl) ether ion ke 1.0, 1.4, le 8.6, ka ho latellana.]
Litlhoko tsa ho tšoaneleha
Qeto: NLT 2.0
Tekanyetso e amanang le maemo: NMT 10.0%
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala peresente ea sodium chloride, 4-hydroxybutane-1-sulfonic acid, kapa bis(sulfobutyl) ether disodium karolong ea Betadex Sulfobutyl Ether Sodium e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × F × 100
rU = karabelo e phahameng ea sodium chloride, 4-hydroxybutane-1-sulfonic acid, kapa bis(sulfobutyl) ether disodium ho tsoa ho Sample solution
rS = karabelo e phahameng ea sodium chloride, 4-hydroxybutane-1-sulfonic acid, kapa bis(sulfobutyl) ether disodium ho tsoa ho tharollo e tloaelehileng
CS = concentration ea sodium chloride, 4-hydroxybutane-1-sulfonic acid, kapa bis(sulfobutyl) ether disodium in the Standard solution (µg/mL)
CU = mahloriso a Betadex Sulfobutyl Ether Sodium ka Sample solution (mg/mL)
F = ntlha ea phetoho (10−3 0 100 0 mg/µg)
Mekhoa ea ho amohela
Sodium chloride: NMT 0.2%
4-Hydroxybutane-1-sulfonic acid: NMT 0.09%
Bis(sulfobutyl) ether disodium: NMT 0.05%
LITEKO TSEKO
TEST EA ENDOTOXINS EA BACTERIAL <85>: Boemo ba li-endotoxins tsa baktheria ke hore tlhokahalo tlas'a foromo e nepahetseng ea tekanyo ea monograph (s) eo Betadex Sulfobutyl Ether Sodium e sebelisoang e ka finyelloang.Moo letšoao le bolelang hore Betadex Sulfobutyl Ether Sodium e tlameha ho kenngoa ts'ebetsong e tsoelang pele nakong ea ho lokisoa ha liforomo tsa litekanyetso tse nang le ente, boemo ba li-endotoxins tsa baktheria ke hore tlhokahalo tlas'a foromo e nepahetseng ea tekanyo ea monograph (s) eo Betadex Sulfobutyl Ether Sodium e sebelisoang ho eona. e ka finyelloa.
• LITEKO TSA MICROBIAL ENUMERATION <61> le LITEKO TSA MICROORGANISMS E KHETHANG <62>: Palo eohle ea aerobic microbial count ha e fete 100 cfu/g, 'me kakaretso ea hlobo e kopantsoeng le tomoso ha e fete 50 cfu/g.E finyella litlhoko tsa tlhahlobo ea ho ba sieo ha Escherichia coli.
• TLHALOSO EA THAROLLO
Tharollo ea mohlala: 30% (w/v) tharollo
Analysis: Hlahloba tharollo ea Mohlala ka ho sebelisa lebokose le khanyang khahlano le bokantle bo bosoeu le bo botšo, 'me u tlalehe boteng ba moholi ofe kapa ofe, fluorescence, fibers, specks, kapa lintho tse ling tse tsoang linaheng tse ling.
Mekhoa ea ho amohela: Tharollo e hlakile, 'me ha e le hantle ha e na likaroloana tsa taba ea kantle ho naha.
• KAROLO EA KHARA-KHANO EA FETISISO
Matha electrolyte: 30 mM benzoic acid 'me e lokisetsoe ho pH e loketseng sesebelisoa se sebelisoang ka ho eketsa 100 mM tris(hydroxymethyl) aminomethane buffer.
[ HLOKOMELA-Ka lebaka la phapang lipakeng tsa li-capillaries, pH e le 'ngoe ea electrolyte e sebetsang hohle ha e ea hlalosoa.
Sebakeng seo, pH e nepahetseng e amanang le capillary ka 'ngoe e lokela ho khethoa ho latela buka ea lisebelisoa.]
Tharollo e tloaelehileng: 10 mg / mL ea USP Betadex Sulfobutyl Ether Sodium RS
Tharollo ea mohlala: 10 mg / mL ea Betadex Sulfobutyl Ether Sodium
Mokhoa oa ho hlatsoa li-capillary: Sebelisa linkho tse arohaneng tsa electrolyte bakeng sa rinse ea capillary le tlhahlobo ea sampole.Etsa li-rinse tsa pele ho tlhahlobo letsatsi le leng le le leng pele ho tlhahlobo e 'ngoe le e' ngoe: hlatsoa capillary ka 0.1 N sodium hydroxide bakeng sa metsotso e 30, ka metsi bakeng sa NLT 2 h, le Run electrolyte bakeng sa NLT 1 h.Etsa lirinse pele ho ente pele ho ente ka 'ngoe ka tsela e latelang.Hlatsoa capillary ka 0.1 N sodium hydroxide bakeng sa NLT 1 min, 'me ka Run electrolyte bakeng sa NLT 3 min.Haeba ho sebelisoa capillary e ncha, ho phaella ho li-rinses tse tloaelehileng tse hlalositsoeng ka holimo, capillary e ncha e hloka ho hlatsoa pele e sebelisoa pele.Hlatsoa capillary e ncha ka 1 M sodium hydroxide bakeng sa 1 h, ebe o lateloa ke rinse ea metsi ea lihora tse 2.
Sistimi ea electrophoretic
(Sheba Capillary Electrophoresis <1053>.)
Mokhoa: Ts'ebetso e phahameng ea CE
Detector: Inverse UV 200 nm, e nang le bandwidth ea 20nm.[HLOKOMELA-Bophahamo ba maqhubu a 205 nm bo nang le bandwidth ea 10 nm bo ka sebelisoa e le mokhoa o mong.]
Kholomo: Sodium Peaks I–X (% Peak Area) 50-µm × 50-cm kholomo ea silica e kopantsoeng
Mocheso oa kholu: 25 °
Matla a sebelisoang: 0.00 ho ea ho +30.00 kV linear remp e fetang metsotso e 10, ebe e le 30 kV bakeng sa metsotso e meng e 20.
Boholo ba ente: Meqolo e lekanang ho 0.5 psi bakeng sa 10 s
Ho nepahala ha sistimi
Mohlala: Tharollo e tloaelehileng
[TLHOKOMELISO-Sheba Lethathamo la 6 bakeng sa linako tse hakanyetsoang tsa ho falla ha betadex sulfobutyl ether sodium peaks I–X (betadex sulfobutyl ether sodium peaks I, II, III, ..., X, e na le molek'hule ea beta cyclodextrin e nang le 1, 2, 3, ..., 10 sulfobutyl substituent(s), ka ho latellana).Linako tse lekanyelitsoeng tsa ho falla ke tsa merero ea tlhahisoleseling feela ho thusa ho tsebahatsa maemo a holimo.]
Lethathamo la 6
| Betadex Sulfobutyl Ether Sodium Peaks I–X | Nako ea Ho falla e Lekaneng |
| I | 0.58 |
| II | 0.63 |
| III | 0.69 |
| IV | 0.77 |
| V | 0.83 |
| VI | 0.91 |
| VII | 1.00 |
| VIII | 1.10 |
| IX | 1.20 |
| X | 1.30 |
Litlhoko tsa ho tšoaneleha
Qeto: NLT 0.9, pakeng tsa betadex sulfobuty ether sodium peak IX le betadex sulfobutyl ether sodium peak X
Tlhahlobo
Mehlala: Sebelisa electrolyte, metsi, tharollo e tloaelehileng, le tharollo ea mohlala
Kenya tharollo e tloaelehileng le tharollo ea Mohlala ka ho sebelisa khatello e fapaneng ea 0.5 psi, e lekanang le 34 mbar, bakeng sa 10 s, e lateloa ke ente ea Run electrolyte ho 0.5 psi bakeng sa 2 s.[HLOKOMELA-Liente tsa khatello li lokela ho etsoa ka vial ea metsi kapa Run electrolyte qetellong ea capillary.]
Rekota li-electropherogram, 'me u lekanye likarabelo tse phahameng ka ho fetisisa bakeng sa litlhōrō tsa sodium ea betadex sulfobutyl ether (I ho isa ho X).Bala sebaka se lokisitsoeng sa tlhoro, AI, bakeng sa tlhoro e 'ngoe le e 'ngoe ea eletropherogram:
Sebaka se Lokisitsoeng sa Peak A = Sebaka se Hloahloa x Bolelele bo sebetsang ba Capillary (cm) / Nako ea ho falla
Ntlafatsa libaka tsa tlhoro tse lokisitsoeng ka ho hlahisa se seng le se seng e le liperesente tsa kakaretso ea sebaka sa enfelopo se lokisitsoeng:
Sebaka sa Nomalized, NA: A / n∑i=1 Ai x 100
n = boemo bo phahameng ka ho fetisisa ba ho nkela sebaka
Etsa qeto ea karolelano ea tekanyo ea ho fetola:
Karolelano ea Khato ea Phapanyetso = n∑i=1 (Boemo ba Phapanyetsano ea Peak x NA) / 100
Mekhoa ea ho amohela: 6.2 ~ 6.9 bakeng sa tekanyo e tloaelehileng ea ho fetola
Bakeng sa e 'ngoe le e 'ngoe ea litlhōrō tsa sodium ea betadex sulfobutyl ether I–X, bona moeli oa moeli (% sebaka sa tlhoro) ho Lethathamo la 7.
Lethathamo la 7
| Betadex Sulfobutyl Ether Sodium Peaks I–X | Limit Range (% Peak Area) |
| I | 0-0.3 |
| II | 0-0.9 |
| III | 0.5-5.0 |
| IV | 2.0-10.0 |
| V | 10.0-20.0 |
| VI | 15.0-25.0 |
| VII | 20.0-30.0 |
| VIII | 10.0-25.0 |
| IX | 2.0-12.0 |
| X | 0-4.0 |
• PH <791>: 4.0-6.8, ka 30% (w/v) tharollo metsing a se nang carbon dioxide
• TLHALOSO EA METSI, Mokhoa oa I <921>: NMT 10.0%
KEKELETSO LIHLOKO
• PAKARETSO LE HO BOLOKA: Boloka ka lijaneng tse koetsoeng hantle, ’me u li boloke mochesong oa kamore.Sireletsa mongobo.
• HO PHAHAMA: E tšoaee ho bontša tšebeliso ea eona ha ho etsoa liforomo tsa litekanyetso tse nang le ente.
• LITEKELO TSA USP REFERENCE <11>
USP Beta Cyclodextrin RS
USP Betadex Sulfobutyl Ether Sodium RS
USP Endotoxin RS
USP Sodium Chloride RS■1S (NF30)
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Betadex Sulfobutyl Ether Sodium (SBE-β-CD; Captisol) (CAS: 182410-00-0) ke mofuta o mocha oa cyclodextrin e entsoeng ka lik'hemik'hale e nang le mohaho o etselitsoeng ho ntlafatsa ho qhibiliha le botsitso ba lithethefatsi.
Betadex Sulfobutyl Ether Sodium ke mofuta o mocha oa motsoako oa ho lokisa meriana, o tsoang ho sulfonic acid e tsoang ho anionic e ngata haholo e qhibilihang ke metsi cyclodextrin.E ka kopanngoa hantle le limolek'hule tsa lithethefatsi ho etsa li-complexes tse sa tsitsang, tse ntlafatsang botsitso, ho qhibiliha ha metsi, le polokeho ea lithethefatsi, 'me ka katleho ho ntlafatsa mosebetsi oa likokoana-hloko oa molek'hule oa lithethefatsi.Nephrotoxicity ea eona e nyane, 'me e ka fokotsa hemolysis ea lithethefatsi., Laola sekhahla sa ho lokolloa ha lithethefatsi.
Betadex Sulfobutyl Ether Sodium e ka etsa li-complexes tse sa sebetseng tse nang le mefuta e mengata ea metsoako e kenyelletsang limolek'hule tse nyane tsa manyolo, li-peptide le liprotheine.E ka boela ea ntlafatsa ho qhibiliha ha tsona le botsitso ba tsona metsing.Tšebeliso ea pele ea sulfobutylether bcyclodextrin e ne e le litokisetsong tsa injectable;e ka boela ea sebelisoa mefuteng ea litekanyetso tsa molomo tse tiileng le tsa metsi, le li-ophthalmic, inhalation, le intranasal formulations.Betadex Sulfobutyl Ether Sodium e ka sebetsa e le moemeli oa osmotic le / kapa solubilizer bakeng sa phano e laoloang, 'me e na le thepa ea ho thibela likokoana-hloko ha e le teng ka bongata bo lekaneng.Palo ea Betadex Sulfobutyl Ether Sodium e ka sebelisoang e itšetlehile ka morero oa ho kenngoa ha ho etsoa, tsela ea tsamaiso, le bokhoni ba cyclodextrin ho rarahaneng le lithethefatsi tse fanoang.
Betadex Sulfobutyl Ether Sodium e tsoa ho b-cyclodextrin, e leng nephrotoxic ha e tsamaisoa ka botsoali.Leha ho le joalo, liphuputso li bontšitse hore sulfobutylether bcyclodextrin e mamelloa hantle ka tekanyo e phahameng, ha e sebelisoa ka liente tsa bolus ka intravenous, ka molomo, le ka ho hema.Ho fihla ho 9 g ka letsatsi ho ka fanoa ka infusion ea IV ka mokhoa o nang le tumello ea ho etsa voriconazole.Tšireletseho e latelang litekanyetso tse phahameng tsa sulfobutylether β-cyclodextrin tsamaisong ea methapo bathong e ntse e tsoela pele ho hlahlojoa.Betadex Sulfobutyl Ether Sodium e behiloe tlas'a betri e pharaletseng ea in vitro le in vivo genotoxicity le litlhahlobo tsa meriana.Ha ho liphetoho tsa genotoxic kapa mutagenic tse ileng tsa bonoa ka tsamaiso ea Sodium ea Betadex Sulfobutyl Ether.Betadex Sulfobutyl Ether Sodium e lumellana le lintho tse phelang 'me ha e bontše tšebetso ea meriana.E tlosoa ka potlako e se na metabolized ha e kenngoa ka methapo.
Betadex Sulfobutyl Ether Sodium e kenyelelitsoe lihlahisoa tsa ente tsa IV le IM tse amoheloang le ho rekisoa USA, Europe le Japane.E kenyelelitsoe ho FDA Inactive Ingredients Database bakeng sa tšebeliso ea IM le IV.Tšebeliso ea eona ke litsela tse ling, ho kenyelletsa SC, molomo, ho hema, nko le mahlo, e ntse e hlahlojoa lithutong tsa bongaka.
Ho sebelisa β-cyclodextrin le 1,4-sulfobutyrolactone e le lisebelisoa tse tala, ka ho hlahisa tekanyo e loketseng ea motsoako oa motsoako ka har'a tharollo ea metsi a alkaline, ho qhibiliha ha 1,4-sulfobutyrolactone ho eketseha, 'me tlhahiso ea tlhahiso ea sulfobutyl ether-β-cyclodexn e ntlafalitsoe;tharollo ea sehlahisoa se fumanoeng e tlas'a ultrasonic dialysis, activated carbon decolorization, freeze drying le ts'ebetso e meng ho fumana lihlahisoa tsa phofo ea sulfobutyl ether-β-cyclodextrin.
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